Keywords
- Howard Hughes Medical Institute
- Include Cell Cycle Arrest
- Gene Activation Response
- Pharmaceutical Optimization
- Cell Cycle Arrest Response
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Lane, D.P. & Crawford, L.V. (1979). Nature, 278, 261–3.
Linzer, D.I. & Levine, A.J. (1979). Cell, 17, 43–52.
Lane, D.P. & Benchimol, S. (1990). Genes Dev, 4, 1–8.
Santibanez-Koref, M.F., Birch, J.M., Hartley, A.L., Jones, P.H., Craft, A.W., Eden, T., Crowther, D., Kelsey, A.M. & Harris, M. (1991). Lancet, 338, 1490–1.
Varley, J.M. (2003). Hum Mutat, 21, 313–20.
Vogelstein, B. & Kinzler, K.W. (1992). Cell, 70, 523–6.
Velculescu, V.E. & El-Deiry, W.S. (1996). Clin Chem, 42, 858–68.
Vogelstein, B., Lane, D. & Levine, A.J. (2000). Nature, 408, 307–10.
Zhao, R., Gish, K., Murphy, M., Yin, Y, Notterman, D., Hoffman, W.H., Tom, E., Mack, D.H. & Levine, A.J. (2000). Genes Dev, 14, 981–93.
El-Deiry, W.S. (2001). Cell Death Differ, 8, 1066–75.
Vousden, K.H. (2000). Cell, 103, 691–4.
Sax, J.K. & El-Deiry, W.S. (2003). Cell Death Differ, 10, 413–7.
El-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. & Vogelstein, B. (1993). Cell, 75, 817–25.
Burns, T.F. & el-Deiry, W.S. (2003). Cancer Treat Res, 115, 319–43.
Burns, T.F., Bernhard, E.J. & El-Deiry, W.S. (2001). Oncogene, 20, 4601–12.
Fei, P., Bernhard, E.J. & El-Deiry, W.S. (2002). Cancer Res, 62, 7316–27.
Oren, M., Damalas, A., Gottlieb, T, Michael, D., Taplick, J., Leal, J.F., Maya, R., Moas, M., Seger, R., Taya, Y. & Ben-Ze’ev, A. (2002). Biochem Pharmacol, 64, 865–71
Kaghad, M., Bonnet, H., Yang, A., Creancier, L., Biscan, J.C., Valent, A., Minty, A., Chalon, P., Lelias, J.M., Dumont, X., Ferrara, P., McKeon, F. & Caput, D. (1997). Cell, 90, 809–19.
Yang, A., Kaghad, M., Wang, Y, Gillett, E., Fleming, M.D., Dotsch, V., Andrews, N.C., Caput, D. & McKeon, F. (1998). Mol Cell, 2, 305–16.
Senoo, M, Seki, N., Ohira, M., Sugano, S., Watanabe, M., Inuzuka, S., Okamoto, T., Tachibana, M., Tanaka, T., Shinkai, Y. & Kato, H. (1998). Biochem Biophys Res Commun, 248, 603–7.
Trink, B., Okami, K., Wu, L., Sriuranpong, V., Jen, J. & Sidransky, D. (1998). Nat Med, 4, 747–8.
Benard, J., Douc-Rasy, S. & Ahomadegbe, J.C. (2003). Hum Mutat, 21, 182–91.
Kaelin, W.G., Jr. (1999). Oncogene, 18, 7701–5.
Yang, A. & McKeon, F. (2000). Nat Rev Mol Cell Biol, 1, 199–207.
Flores, E.R., Tsai, K.Y., Crowley, D., Sengupta, S., Yang, A., McKeon, F. & Jacks, T. (2002). Nature, 416, 560–4.
Bergamaschi, D., Samuels, Y, O’Neil, N.J., Trigiante, G., Crook, T., Hsieh, J.K., O’Connor, D.J., Zhong, S., Campargue, I., Tomlinson, M.L., Kuwabara, P.E. & Lu, X. (2003). Nat Genet, 33, 162–7.
Freeman, D.J., Li, A.G., Wei, G., Li, H.H., Kertesz, N., Lesche, R., Whale, A.D., Martinez-Diaz, H., Rozengurt, N., Cardiff, R.D., Liu, X. & Wu, H. (2003). Cancer Cell, 3, 117–30.
MacLachlan, T.K. & El-Deiry, W.S. (2002). Proc Natl Acad Sci U S A, 99, 9492–7.
Slee, E.A. & Lu, X. (2003). Toxicol Lett, 139, 81–7.
Bergamaschi, D., Gasco, M., Hiller, L., Sullivan, A., Syed, N., Trigiante, G., Yulug, I., Merlano, M., Numico, G., Comino, A., Attard, M., Reelfs, O., Gusterson, B., Bell, A.K., Heath, V., Tavassoli, M., Farrell, P.J., Smith, P., Lu, X. & Crook, T. (2003). Cancer Cell, 3, 387–402.
Irwin, M.S., Kondo, K., Marin, M.C., Cheng, L.S., Hahn, W.C. & Kaelin, W.G. (2003). Cancer Cell, 3, 403–10.
Melino, G., De Laurenzi, V. & Vousden, K.H. (2002). Nat Rev Cancer, 2, 605–15.
Moll, U.M., LaQuaglia, M., Benard, J. & Riou, G. (1995). Proc Natl Acad Sci U S A, 92, 4407–11.
Hibi, K., Trink, B., Patturajan, M., Westra, W.H., Caballero, O.L., Hill, D.E., Ratovitski, E.A., Jen, J. & Sidransky, D. (2000). Proc Natl Acad Sci U S A, 97, 5462–7.
Vousden, K.H. & Lu, X. (2002). Nat Rev Cancer, 2, 594–604.
Kubbutat, M.H., Jones, S.N. & Vousden, K.H. (1997). Nature, 387, 299–303.
Wu, X., Bayle, J.H., Olson, D. & Levine, A.J. (1993). Genes Dev, 7, 1126–32.
Grossman, S.R., Perez, M., Kung, A.L., Joseph, M., Mansur, C., Xiao, Z.X., Kumar, S., Howley, P.M. & Livingston, D.M. (1998). Mol Cell, 2, 405–15.
Oliner, J.D., Pietenpol, J.A., Thiagalingam, S., Gyuris, J., Kinzler, K.W. & Vogelstein, B. (1993). Nature, 362, 857–60.
Haupt, Y., Maya, R., Kazaz, A. & Oren, M. (1997). Nature, 387, 296–9.
Grossman, S.R., Deato, M.E., Brignone, C., Chan, H.M., Kung, A.L., Tagami, H., Nakatani, Y. & Livingston, D.M. (2003). Science, 300, 342–4.
Mayo, L.D. & Donner, D.B. (2001). Proc Natl Acad Sci U S A, 98, 11598–603.
Zhou, B.P., Liao, Y., Xia, W., Zou, Y., Spohn, B. & Hung, M.C. (2001). Nat Cell Biol, 3, 973–82.
Sabbatini, P. & McCormick, F. (1999). J Biol Chem, 274, 24263–9.
Basu, S., Totty, N.F., Irwin, M.S., Sudol, M. & Downward, J. (2003). Mol Cell, 11, 11–23.
Broome, M.A. & Courtneidge, S.A. (2000). Oncogene, 19, 2867–9.
Schreiber, M., Kolbus, A., Piu, R, Szabowski, A., Mohle-Steinlein, U., Tian, J., Karin, M., Angel, P. & Wagner, E.F. (1999). Genes Dev, 13, 607–19.
Leng, R.P., Lin, Y, Ma, W., Wu, H., Lemmers, B., Chung, S., Parant, J.M., Lozano, G., Hakem, R. & Benchimol, S. (2003). Cell, 112, 779–91.
Woods, D.B. & Vousden, K.H. (2001). Exp Cell Res, 264, 56–66.
Bakkenist, C.J. & Kastan, M.B. (2003). Nature, 421, 499–506.
Ashcroft, M., Taya, Y. & Vousden, K.H. (2000) Mol Cell Biol, 20, 3224–33.
Brooks, C.L. & Gu, W. (2003). Curr Opin Cell Biol, 15, 164–71.
Blagosklonny, M.V. & el-Deiry, W.S. (1996). Int J Cancer, 67, 386–92.
Blagosklonny, M.V. & El-Deiry, W.S. (1998). Int J Cancer, 75, 933–40.
Wu, G.S. & El-Deiry, W.S. (1996). Clin Cancer Res, 2, 623–33.
Chen, J., Willingham, T., Shuford, M., Bruce, D., Rushing, E., Smith, Y. & Nisen, P.D. (1996). Oncogene, 13, 1395–403.
Kaeser, M.D. & Iggo, R.D. (2002). Proc Natl Acad Sci U S A, 99, 95–100.
Szak, ST., Mays, D. & Pietenpol, J.A. (2001). Mol Cell Biol, 21, 3375–86.
Samuels-Lev, Y., O’Connor, D.J., Bergamaschi, D., Trigiante, G., Hsieh, J.K., Zhong, S., Campargue, I., Naumovski, L., Crook, T. & Lu, X. (2001). Mol Cell, 8, 781–94.
Komarova, E.A., Christov, K., Faerman, A.I. & Gudkov, A.V. (2000). Oncogene, 19, 3791–8.
Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A. & Jacks, T. (1993). Nature, 362, 847–9.
Clayman, G.L., el-Naggar, A.K., Roth, J.A., Zhang, W.W., Goepfert, H., Taylor, D.L. & Liu, T.J. (1995). Cancer Res, 55, 1–6.
Nishizaki, M., Meyn, R.E., Levy, L.B., Atkinson, E.N., White, R.A., Roth, J.A. & Ji, L. (2001) Clin Cancer Res, 7, 2887–97.
Hamid, O., Varterasian, M.L., Wadler, S., Hecht, J.R., Benson, A., 3rd, Galanis, E., Uprichard, M., Omer, C., Bycott, P., Hackman, R.C. & Shields, A.F. (2003) J Clin Oncol, 21, 1498–504.
Hecht, J.R., Bedford, R., Abbruzzese, J.L., Lahoti, S., Reid, T.R., Soetikno, R.M., Kirn, D.H. & Freeman, S.M. (2003) Clin Cancer Res, 9, 555–61.
Komarov, P.G., Komarova, E.A., Kondratov, R.V., Christov-Tselkov, K., Coon, J.S., Chernov, M.V. & Gudkov, A.V. (1999) Science, 285, 1733–7.
Foster, B.A., Coffey, H.A., Morin, M.J. & Rastinejad, F. (1999) Science, 286, 2507–10.
Takimoto, R., Wang, W., Dicker, D.T., Rastinejad, F., Lyssikatos, J. & el-Deiry, W.S. (2002) Cancer Biol Ther, 1, 47–55.
Wang, W., Takimoto, R., Rastinejad, F. & El-Deiry, W.S. (2003) Mol Cell Biol, 23, 2171–81.
Bykov, V.J., Issaeva, N., Selivanova, G. & Wiman, K.G. (2002) Carcinogenesis, 23, 2011–8.
Peng, Y, Li, C., Chen, L, Sebti, S. & Chen, J. (2003) Oncogene, 22, 4478–87.
Friedler, A., Hansson, L.O., Veprintsev, D.B., Freund, S.M., Rippin, T.M., Nikolova, P.V., Proctor, M.R., Rudiger, S. & Fersht, A.R. (2002) Proc Natl Acad Sci U S A, 99, 937–42.
Sohn, T.A., Bansal, R., Su, G.H., Murphy, K.M. & Kern, S.E. (2002). Carcinogenesis, 23, 949–57.
Sax, J.K., Fei, P., Murphy, M.E., Bernhard, E., Korsmeyer, S.J. & El-Deiry, W.S. (2002). Nat Cell Biol, 4, 842–9.
Chene, P. (2003). Expert Opin Ther Targets, 7, 453–61.
Bottger, A., Bottger, V., Sparks, A., Liu, W.L., Howard, S.F. & Lane, D.P. (1997). Curr Biol, 7, 860–9.
Bottger, V., Bottger, A., Howard, S.F., Picksley, S.M., Chene, P., Garcia-Echeverria, C., Hochkeppel, H.K. & Lane, D.P. (1996). Oncogene, 13, 2141–7.
Midgley, C.A., Desterro, J.M., Saville, M.K., Howard, S., Sparks, A., Hay, R.T. & Lane, D.P. (2000). Oncogene, 19, 2312–23.
Donehower, L.A. (1996). Semin Cancer Biol, 7, 269–78
Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Jr., Butel, J.S. & Bradley, A. (1992). Nature, 356, 215–21.
Jacks, T, Remington, L., Williams, B.O., Schmitt, E.M., Halachmi, S., Bronson, R.T. & Weinberg, R.A. (1994). Curr Biol, 4, 1–7.
Roth, J., Dobbelstein, M., Freedman, D.A., Shenk, T. & Levine, A.J. (1998). Embo J, 17, 554–64.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Kluwer Academic Publishers
About this chapter
Cite this chapter
Wang, S., El-Deiry, W.S. (2004). The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics. In: Kumar, R. (eds) Molecular Targeting and Signal Transduction. Cancer Treatment and Research, vol 119. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7847-1_9
Download citation
DOI: https://doi.org/10.1007/1-4020-7847-1_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4020-7822-4
Online ISBN: 978-1-4020-7847-7
eBook Packages: Springer Book Archive