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Histone Variants and Complexes Involved in Their Exchange

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Chromatin and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 41))

In contrast to canonical histones, which are assembled into nucleosomes during DNA replication, histone variants can be incorporated into specific regions of the genome throughout the cell cycle. Recent findings suggest that histone variants associate with factors mediating their deposition into specialized chromatin domains. The mechanisms of their targeted deposition, their turnover, and their posttranslational modification are not yet fully understood. Emerging evidence indicates that histone variants and associated factors are essential for the epigenetic control of gene expression and other cellular responses. Thus, histone variants and complexes involved in their exchange are likely to play major roles in controlling chromosomal architecture, and their deregulation is expected to be linked to cancers, infertility, mental disorders, ageing, and degenerative diseases

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Room #123A, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA

    Thomas Kusch

  2. Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA

    Jerry L. Workman

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  1. Thomas Kusch
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Editor information

Editors and Affiliations

  1. Jawaharlal Centre for Advanced Scientific Research, Jakkur, Bangalore, India

    Tapas K. Kundu

  2. Queens College,City University of New York, New York, USA

    R. Bittman

  3. Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  4. Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt

  5. MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  6. German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  7. Texas A & M University, Texas, USA

    A. Holzenburg

  8. National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  9. The Hebrew University, Jerusalem, Israel

    S. Rottem

  10. DSM Nutritional Products Ltd, Basel, Switzerland

    M. Wyss

  11. Max-Planck-Institute for Biochemistry, Munich, Germany

    P. Zwickl

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Kusch, T., Workman, J.L. (2007). Histone Variants and Complexes Involved in Their Exchange. In: Kundu, T.K., et al. Chromatin and Disease. Subcellular Biochemistry, vol 41. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5466-1_5

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