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Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1

Possible targets for drug-based therapies

  • Chapter
Book cover Chromatin and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 41))

Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD+ molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1’s chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1’s enzymatic activity for the treatment of human diseases

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Authors and Affiliations

  1. Department of Molecular Biology and Genetics, Cornell University, 465 Biotechnology Building, Ithaca, NY 14853

    David A. Wacker, Kristine M. Frizzell, Tong Zhang & W. Lee Kraus

  2. Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021

    W. Lee Kraus

Authors
  1. David A. Wacker
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  2. Kristine M. Frizzell
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  3. Tong Zhang
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  4. W. Lee Kraus
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Editor information

Editors and Affiliations

  1. Jawaharlal Centre for Advanced Scientific Research, Jakkur, Bangalore, India

    Tapas K. Kundu

  2. Queens College,City University of New York, New York, USA

    R. Bittman

  3. Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  4. Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt

  5. MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  6. German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  7. Texas A & M University, Texas, USA

    A. Holzenburg

  8. National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  9. The Hebrew University, Jerusalem, Israel

    S. Rottem

  10. DSM Nutritional Products Ltd, Basel, Switzerland

    M. Wyss

  11. Max-Planck-Institute for Biochemistry, Munich, Germany

    P. Zwickl

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Wacker, D.A., Frizzell, K.M., Zhang, T., Kraus, W.L. (2007). Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1. In: Kundu, T.K., et al. Chromatin and Disease. Subcellular Biochemistry, vol 41. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5466-1_3

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