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Smad Signal Transduction pp 151–176Cite as

Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer

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Part of the book series: Proteins and Cell Regulation ((PROR,volume 5))

Abstract

Mammalian Smads consist of a gene family of 8 members that serve as intracellular mediators of TGF-β signaling. Functions of Smads have been elucidated through extensive research using gene targeting technologies to introduce various types of mutations into these genes. Analysis of mutant mice has uncovered important functions of Smads in numerous biological processes, including gastrulation, mesoderm induction and patterning, angiogenesis, cell proliferation and differentiation, organogenesis, immunological response, wound healing, and tumorigenesis. Here we summarize these studies and discuss possible mechanisms underlying phenotypic alterations associated with the deficiency of each Smad

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Authors and Affiliations

  1. Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA

    Michael Weinstein

  2. Mammalian Genetics Section, Genetics of Development and Disease Branch, Digestive and Kidney Diseases, National Institutes of Health, 10/9N105, 10 Center Drive, Bethesda, MD 20892, USA

    Chu-Xia Deng

Authors
  1. Michael Weinstein
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  2. Chu-Xia Deng
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Editors and Affiliations

  1. Leiden University Medical Center, Leiden, The Netherlands

    Peter ten Dijke

  2. Ludwig Institute for Cancer Research, Uppsala University, Sweden

    Carl-Henrik Heldin

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Weinstein, M., Deng, CX. (2006). Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer. In: Dijke, P.t., Heldin, CH. (eds) Smad Signal Transduction. Proteins and Cell Regulation, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4709-6_8

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