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Frontiers in Planar Lightwave Circuit Technology

Volume 216 of the series NATO Science Series II: Mathematics, Physics and Chemistry pp 119-140

OPTICAL BIOSENSOR DEVICES AS EARLY DETECTORS OF BIOLOGICAL AND CHEMICAL WARFARE AGENTS

  • L.M. LechugaAffiliated withMicroelectronics National Center, CSIC
  • , E. MaurizAffiliated withMicroelectronics National Center, CSIC
  • , B. SepúlvedaAffiliated withMicroelectronics National Center, CSIC
  • , J. Sánchez del RíoAffiliated withMicroelectronics National Center, CSIC
  • , A. CalleAffiliated withMicroelectronics National Center, CSIC
  • , G. ArmellesAffiliated withMicroelectronics National Center, CSIC
  • , C. DomínguezAffiliated withMicroelectronics National Center, CSIC

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Abstract

The present article reviews three different optical biosensing mechanisms that can be implemented in a multibiosensor technology platform: surface plasmon resonance, magnetooptical surface plasmon resonance and optoelectronic biosensing (evanescent wave detection) using integrated Mach-Zehnder interferometer devices. In the last case, the use of standard silicon microelectronics technology opens the possibility for integration of optical, fluidics based and electrical functions within a single optical sensing circuit leading to a complete lab-on-a-chip design solution. All three mechanisms can be efficiently used as an early warning system for biological and/or chemical warfare.