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References
Ahmed, S., and J. Hodgkin. 2000. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans. Nature. 403:159–64.
Alcorta, D.A., Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J.C. Barrett. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A. 93:13742–7.
Allsopp, R.C., and C.B. Harley. 1995. Evidence for a critical telomere length in senescent human fibroblasts. Exp Cell Res. 219:130–6.
Allsopp, R.C., H. Vaziri, C. Patterson, S. Goldstein, E.V. Younglai, A.B. Futcher, C.W. Greider, and C.B. Harley. 1992. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A. 89:10114–8.
Ancelin, K., M. Brunori, S. Bauwens, C.E. Koering, C. Brun, M. Ricoul, J.P. Pommier, L. Sabatier, and E. Gilson. 2002. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol Cell Biol. 22:3474–87.
Artandi, S.E., S. Chang, S.L. Lee, S. Alson, G.J. Gottlieb, L. Chin, and R.A. DePinho. 2000. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406:641–5.
Artandi, S.E., and R.A. DePinho. 2000. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev. 10:39–46.
Bai, Y., and J.P. Murnane. 2003. Telomere instability in a human tumour cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol Cancer Res. 1:1058–69.
Bailey, S.M., M.A. Brenneman, J. Halbrook, J.A. Nickoloff, R.L. Ullrich, and E.H. Goodwin. 2004. The kinase activity of DNA-PK is required to protect mammalian telomeres. DNA Repair (Amst). 3:225–33.
Bailey, S.M., M.N. Cornforth, A. Kurimasa, D.J. Chen, and E.H. Goodwin. 2001. Strand-specific postreplicative processing of mammalian telomeres. Science. 293:2462–5.
Bakkenist, C.J., and M.B. Kastan. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499–506.
Balin, A.K., A.J. Fisher, and D.M. Carter. 1984. Oxygen modulates growth of human cells at physiologic partial pressures. J Exp Med. 160:152–66.
Baumann, P., and T.R. Cech. 2000. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 11:3265–75.
Baumann, P., and T.R. Cech. 2001. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 292:1171–5.
Beausejour, C.M., A. Krtolica, F. Galimi, M. Narita, S.W. Lowe, P. Yaswen, and J. Campisi. 2003. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 22:4212–22.
Bechter, O.E., Y. Zou, W. Walker, W.E. Wright, and J.W. Shay. 2004. Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Res. 64:3444–51.
Bertuch, A.A., K. Buckley, and V. Lundblad. 2003. The way to the end matters—the role of telomerase in tumour progression. Cell Cycle. 2:36–8.
Bessler, J.B., J.Z. Torredagger, and V.A. Zakian. 2001. The Pif1p subfamily of helicases: region-specific DNA helicases? Trends Cell Biol. 11:60–5.
Bi, X., S.C. Wei, and Y.S. Rong. 2004. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Curr Biol. 14:1348–53.
Blackburn, E.H. 1991. Structure and function of telomeres. Nature. 350:569–73.
Blackburn, E.H. 2001. Switching and signalling at the telomere. Cell. 106:661–73.
Blackburn, E.H., S. Chan, J. Chang, T.B. Fulton, A. Krauskopf, M. McEachern, J. Prescott, J. Roy, C. Smith, and H. Wang. 2000. Molecular manifestations and molecular determinants of telomere capping. Cold Spring Harb Symp Quant Biol. 65:253–63.
Blasco, M.A., W. Funk, B. Villeponteau, and C.W. Greider. 1995. Functional characterization and developmental regulation of mouse telomerase RNA. Science. 269:1267–70.
Blasco, M.A., H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, R.A. DePinho, and C.W. Greider. 1997. Telomere shortening and tumour formation by mouse cells lacking telomerase RNA. Cell. 91:25–34.
Bodnar, A.G., M. Ouellette, M. Frolkis, S.E. Holt, C.P. Chiu, G.B. Morin, C.B. Harley, J.W. Shay, S. Lichtsteiner, and W.E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science. 279:349–52.
Boulton, S.J., and S.P. Jackson. 1996. Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucleic Acids Res. 24:4639–48.
Boulton, S.J., and S.P. Jackson. 1998. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819–28.
Bradshaw, P.S., D.J. Stavropoulus, and M.S. Meyn. 2005. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat. Genet. 37:193–197
Brown, E.J., and D. Baltimore. 2000. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14:397–402.
Brown, J.P., W. Wei, and J.M. Sedivy. 1997. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science. 277:831–4.
Bryan, T.M., A. Englezou, L. Dalla-Pozza, M.A. Dunham, and R.R. Reddel. 1997. Evidence for an alternative mechanism for maintaining telomere length in human tumours and tumour-derived cell lines. Nat Med. 3:1271–4.
Bryan, T.M., A. Englezou, J. Gupta, S. Bacchetti, and R.R. Reddel. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:4240–8.
Bryan, T.M., J.M. Sperger, K.B. Chapman, and T.R. Cech. 1998. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 95:8479–84.
Carson, C.T., R.A. Schwartz, T.H. Stracker, C.E. Lilley, D.V. Lee, and M.D. Weitzman. 2003. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 22:6610–20.
Cawthon, R.M., K.R. Smith, E. O’Brien, A. Sivatchenko, and R.A. Kerber. 2003. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 361:393–5.
Chadeneau, C., K. Hay, H.W. Hirte, S. Gallinger, and S. Bacchetti. 1995. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res. 55:2533–6.
Chang, S., C.M. Khoo, M.L. Naylor, R.S. Maser, and R.A. DePinho. 2003. Telomere-based crisis: functional differences between telomerase activation and ALT in tumour progression. Genes Dev. 17:88–100.
Chin, K., C.O. de Solorzano, D. Knowles, A. Jones, W. Chou, E.G. Rodriguez, W.L. Kuo, B.M. Ljung, K. Chew, K. Myambo, M. Miranda, S. Krig, J. Garbe, M. Stampfer, P. Yaswen, J.W. Gray, and S.J. Lockett. 2004. In situ analyses of genome instability in breast cancer. Nat Genet. 36:984–8.
Chin, L., S.E. Artandi, Q. Shen, A. Tam, S.L. Lee, G.J. Gottlieb, C.W. Greider, and R.A. DePinho. 1999. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97:527–38.
Ciapponi, L., G. Cenci, J. Ducau, C. Flores, D. Johnson-Schlitz, M.M. Gorski, W.R. Engels, and M. Gatti. 2004. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 14:1360–6.
Colgin, L.M., K. Baran, P. Baumann, T.R. Cech, and R.R. Reddel. 2003. Human POT1 facilitates telomere elongation by telomerase. Curr Biol. 13:942–6.
Collins, K., and L. Gandhi. 1998. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc Natl Acad Sci U S A. 95:8485–90.
Conrad, M.N., J.H. Wright, A.J. Wolf, and V.A. Zakian. 1990. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell. 63:739–50.
Corda, Y., V. Schramke, M.P. Longhese, T. Smokvina, V. Paciotti, V. Brevet, E. Gilson, and V. Geli. 1999. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Nat Genet. 21:204–8.
Counter, C.M., A.A. Avilion, C.E. LeFeuvre, N.G. Stewart, C.W. Greider, C.B. Harley, and S. Bacchetti. 1992. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921–9.
Craven, R.J., and T.D. Petes. 1999. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. Genetics. 152:1531–41.
d’Adda di Fagagna, F., M.P. Hande, W.M. Tong, D. Roth, P.M. Lansdorp, Z.Q. Wang, and S.P. Jackson. 2001. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr Biol. 11:1192–6.
d’Adda di Fagagna, F., P.M. Reaper, L. Clay-Farrace, H. Fiegler, P. Carr, T. Von Zglinicki, G. Saretzki, N.P. Carter, and S.P. Jackson. 2003. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 426:194–8.
d’Adda di Fagagna, F., S.H. Teo, and S.P. Jackson. 2004. Functional links between telomeres and proteins of the DNA damage response. Genes Dev. 18:1781–99.
D’Amours, D., S. Desnoyers, I. D’silva, and G.G. Poirier. 1999. Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J. 342 (Pt 2):249–68.
DePinho, R.A. 2000. The age of cancer. Nature. 408:248–54.
Diede, S.J., and D.E. Gottschling. 2001. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Curr Biol. 11:1336–40.
Djojosubroto, M.W., Y.S. Choi, H.W. Lee, and K.L. Rudolph. 2003. Telomeres and telomerase in aging, regeneration and cancer. Mol Cells. 15:164–75.
Dokal, I. 2001. Dyskeratosis congenita. A disease of premature ageing. Lancet. 358Suppl:S27.
Donehower, L.A., M. Harvey, B.L. Slagle, M.J. McArthur, C.A. Montgomery, Jr., J.S. Butel, and A. Bradley. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:215–21.
Dynek, J.N., and S. Smith. 2004. Resolution of sister telomere association is required for progression through mitosis. Science. 304:97–100.
Eller, M.S., N. Puri, I.M. Hadshiew, S.S. Venna, and B.A. Gilchrest. 2002. Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp Cell Res. 276:185–93.
Ellison, V., and B. Stillman. 2003. Biochemical Characterization of DNA Damage Checkpoint Complexes: Clamp Loader and Clamp Complexes with Specificity for 5′ Recessed DNA. PLoS Biol. 1:E33
Espejel, S., S. Franco, A. Sgura, D. Gae, S.M. Bailey, G.E. Taccioli, and M.A. Blasco. 2002. Functional interaction between DNA-PKcs and telomerase in telomere length maintenance. EMBO J. 21:6275–87.
Farazi, P.A., J. Glickman, S. Jiang, A. Yu, K.L. Rudolph, and R.A. DePinho. 2003. Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. Cancer Res. 63:5021–7.
Feng, J., W.D. Funk, S.S. Wang, S.L. Weinrich, A.A. Avilion, C.P. Chiu, R.R. Adams, E. Chang, R.C. Allsopp, J. Yu, and et al. 1995. The RNA component of human telomerase. Science. 269:1236–41.
Forsyth, N.R., A.P. Evans, J.W. Shay, and W.E. Wright. 2003. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell. 2:235–43.
Futreal, P.A., and J.C. Barrett. 1991. Failure of senescent cells to phosphorylate the RB protein. Oncogene. 6:1109–13.
Gallego, M.E., and C.I. White. 2001. RAD50 function is essential for telomere maintenance in Arabidopsis. Proc Natl Acad Sci U S A. 98:1711–6.
Gilley, D., H. Tanaka, M.P. Hande, A. Kurimasa, G.C. Li, M. Oshimura, and D.J. Chen. 2001. DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A. 98:15084–8.
Gonzalez-Suarez, E., E. Samper, J.M. Flores, and M.A. Blasco. 2000. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet. 2:114–7.
Grandin, N., C. Damon, and M. Charbonneau. 2001. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20:1173–83.
Gravel, S., M. Larrivee, P. Labrecque, and R.J. Wellinger. 1998. Yeast Ku as a regulator of chromosomal DNA end structure. Science. 280:741–4.
Greenberg, R.A., R.C. Allsopp, L. Chin, G.B. Morin, and R.A. DePinho. 1998. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 16:1723–30.
Greenberg, R.A., L. Chin, A. Femino, K.H. Lee, G.J. Gottlieb, R.H. Singer, C.W. Greider, and R.A. DePinho. 1999. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97:515–25.
Greenwell, P.W., S.L. Kronmal, S.E. Porter, J. Gassenhuber, B. Obermaier, and T.D. Petes. 1995. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia-telangiectasia gene. Cell. 82:823–9.
Griffith, J.D., L. Comeau, S. Rosenfield, R.M. Stansel, A. Bianchi, H. Moss, and T. de Lange. 1999. Mammalian telomeres end in a large duplex loop. Cell. 97:503–14.
Grossi, S., A. Bianchi, P. Damay, and D. Shore. 2001. Telomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination. Mol Cell Biol. 21:8117–28.
Hahn, W.C., C.M. Counter, A.S. Lundberg, R.L. Beijersbergen, M.W. Brooks, and R.A. Weinberg. 1999a. Creation of human tumour cells with defined genetic elements. Nature. 400:464–8.
Hahn, W.C., S.A. Stewart, M.W. Brooks, S.G. York, E. Eaton, A. Kurachi, R.L. Beijersbergen, J.H. Knoll, M. Meyerson, and R.A. Weinberg. 1999b. Inhibition of telomerase limits the growth of human cancer cells. Nat Med. 5:1164–70.
Hande, M.P., A.S. Balajee, and A.T. Natarajan. 1997. Induction of telomerase activity by UV-irradiation in Chinese hamster cells. Oncogene. 15:1747–52.
Hande, M.P., A.S. Balajee, A. Tchirkov, A. Wynshaw-Boris, and P.M. Lansdorp. 2001. Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxiatelangiectasia. Hum Mol Genet. 10:519–28.
Hande, M.P., P.M. Lansdorp, and A.T. Natarajan. 1998. Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing. Mutat Res. 404:205–14.
Hande, M.P., E. Samper, P. Lansdorp, and M.A. Blasco. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol. 144:589–601.
Hara, E., R. Smith, D. Parry, H. Tahara, S. Stone, and G. Peters. 1996. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence. Mol Cell Biol. 16:859–67.
Hardy, C.F., L. Sussel, and D. Shore. 1992. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6:801–14.
Harrington, L.A., and C.W. Greider. 1991. Telomerase primer specificity and chromosome healing. Nature. 353:451–4.
Hayflick, L. 1979. The cell biology of aging. J Invest Dermatol. 73:8–14.
Henderson, E.R., and E.H. Blackburn. 1989. An overhanging 3′ terminus is a conserved feature of telomeres. Mol Cell Biol. 9:345–8.
Herbig, U., W.A. Jobling, B.P. Chen, D.J. Chen, and J.M. Sedivy. 2004. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell. 14:501–13.
Hicke, B.J., D.W. Celander, G.H. MacDonald, C.M. Price, and T.R. Cech. 1990. Two versions of the gene encoding the 41-kilodalton subunit of the telomere binding protein of Oxytricha nova. Proc Natl Acad Sci U S A. 87:1481–5.
Hsu, H.L., D. Gilley, S.A. Galande, M.P. Hande, B. Allen, S.H. Kim, G.C. Li, J. Campisi, T. Kohwi-Shigematsu, and D.J. Chen. 2000. Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14:2807–12.
Hughes, T.R., R.G. Weilbaecher, M. Walterscheid, and V. Lundblad. 2000. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein. Proc Natl Acad Sci U S A. 97:6457–62.
Itahana, K., Y. Zou, Y. Itahana, J.L. Martinez, C. Beausejour, J.J. Jacobs, M. Van Lohuizen, V. Band, J. Campisi, and G.P. Dimri. 2003. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol. 23:389–401.
Jacks, T., L. Remington, B.O. Williams, E.M. Schmitt, S. Halachmi, R.T. Bronson, and R.A. Weinberg. 1994. Tumour spectrum analysis in p53-mutant mice. Curr Biol. 4:1–7.
Jaco, I., P. Munoz, F. Goytisolo, J. Wesoly, S. Bailey, G. Taccioli, and M.A. Blasco. 2003. Role of mammalian Rad54 in telomere length maintenance. Mol Cell Biol. 23:5572–80.
Jasin, M. 2000. Chromosome breaks and genomic instability. Cancer Invest. 18:78–86.
Kanellis, P., R. Agyei, and D. Durocher. 2003. Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol. 13:1583–95.
Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science. 283:1321–5.
Karlseder, J., K. Hoke, O.K. Mirzoeva, C. Bakkenist, M.B. Kastan, J.H. Petrini, and T. de Lange. 2004. The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response. PLoS Biol. 2:E240.
Karlseder, J., L. Kachatrian, H. Takai, K. Mercer, S. Hingorani, T. Jacks, and T. de Lange. 2003. Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol Cell Biol. 23:6533–41.
Karlseder, J., A. Smogorzewska, and T. de Lange. 2002. Senescence induced by altered telomere state, not telomere loss. Science. 295:2446–9.
Kharbanda, S., V. Kumar, S. Dhar, P. Pandey, C. Chen, P. Majumder, Z.M. Yuan, Y. Whang, W. Strauss, T.K. Pandita, D. Weaver, and D. Kufe. 2000. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr Biol. 10:568–75.
Kim, N.W., M.A. Piatyszek, K.R. Prowse, C.B. Harley, M.D. West, P.L. Ho, G.M. Coviello, W.E. Wright, S.L. Weinrich, and J.W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science. 266:2011–5.
Kim, S.H., P. Kaminker, and J. Campisi. 1999. TIN2, a new regulator of telomere length in human cells. Nat Genet. 23:405–12.
Kirk, K.E., B.P. Harmon, I.K. Reichardt, J.W. Sedat, and E.H. Blackburn. 1997. Block in anaphase chromosome separation caused by a telomerase template mutation. Science. 275:1478–81.
Kyrion, G., K.A. Boakye, and A.J. Lustig. 1992. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol. 12:5159–73.
Le, S., J.K. Moore, J.E. Haber, and C.W. Greider. 1999. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics. 152:143–52.
Lechel A., A. Satyanarayana, Z. Ju, R.R. Plentz, S. Schaetzlein, C. Rudolph, L. Wilkens, S.U. Wiemann, G. Saretzki, N.P. Malek, M.P. Manns, J. Buer, and K.L. Rudolph. 2005. The Cellular Level of Telomere Dysfunction Determines Induction of Senescence or Apoptosis in vivo. EMBO Rep. Epub ahead of print
Lee, H.W., M.A. Blasco, G.J. Gottlieb, J.W. Horner, 2nd, C.W. Greider, and R.A. DePinho. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:569–74.
Lee, J.H., and T.T. Paull. 2004. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 304:93–6.
Lee, K.H., K.L. Rudolph, Y.J. Ju, R.A. Greenberg, L. Cannizzaro, L. Chin, S.R. Weiler, and R.A. DePinho. 2001. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci U S A. 98:3381–6.
Li, B., and T. de Lange. 2003. Rap1 affects the length and heterogeneity of human telomeres. Mol Biol Cell. 14:5060–8.
Li, B., S. Oestreich, and T. de Lange. 2000. Identification of human Rap1: implications for telomere evolution. Cell. 101:471–83.
Li, G., C. Nelsen, and E.A. Hendrickson. 2002. Ku86 is essential in human somatic cells. Proc Natl Acad Sci U S A. 99:832–7.
Li, G.Z., M.S. Eller, R. Firoozabadi, and B.A. Gilchrest. 2003. Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci U S A. 100:527–31.
Lin, A.W., M. Barradas, J.C. Stone, L. van Aelst, M. Serrano, and S.W. Lowe. 1998. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalling. Genes Dev. 12:3008–19.
Lingner, J., T.R. Hughes, A. Shevchenko, M. Mann, V. Lundblad, and T.R. Cech. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 276:561–7.
Longhese, M.P., V. Paciotti, H. Neecke, and G. Lucchini. 2000. Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast. Genetics. 155:1577–91.
Lowe, S.W., T. Jacks, D.E. Housman, and H.E. Ruley. 1994. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A. 91:2026–30.
Lundblad, V., and E.H. Blackburn. 1993. An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell. 73:347–60.
Lustig, A.J., S. Kurtz, and D. Shore. 1990. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science. 250:549–53.
Lustig, A.J., and T.D. Petes. 1986. Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A. 83:1398–402.
Makarov, V.L., Y. Hirose, and J.P. Langmore. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell. 88:657–66.
Mallory, J.C., V.I. Bashkirov, K.M. Trujillo, J.A. Solinger, M. Dominska, P. Sung, W.D. Heyer, and T.D. Petes. 2003. Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. DNA Repair (Amst). 2:1041–64.
Mangahas, J.L., M.K. Alexander, L.L. Sandell, and V.A. Zakian. 2001. Repair of chromosome ends after telomere loss in Saccharomyces. Mol Biol Cell. 12:4078–89.
Marcand, S., V. Brevet, and E. Gilson. 1999. Progressive cis-inhibition of telomerase upon telomere elongation. EMBO J. 18:3509–19.
Marcand, S., E. Gilson, and D. Shore. 1997. A protein-counting mechanism for telomere length regulation in yeast. Science. 275:986–90.
Maringele, L., and D. Lydall. 2002. EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev. 16:1919–33.
Martin, S.G., T. Laroche, N. Suka, M. Grunstein, and S.M. Gasser. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell. 9:621–33.
Maser, R.S., and R.A. DePinho. 2003. Take care of your chromosomes lest cancer take care of you. Cancer Cell. 3:4–6.
Masutomi, K., E.Y. Yu, S. Khurts, I. Ben-Porath, J.L. Currier, G.B. Metz, M.W. Brooks, S. Kaneko, S. Murakami, J.A. DeCaprio, R.A. Weinberg, S.A. Stewart, and W.C. Hahn. 2003. Telomerase maintains telomere structure in normal human cells. Cell. 114:241–53.
Matsuura, A., T. Naito, and F. Ishikawa. 1999. Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3(+) and tel1(+) are parts of two regulatory networks independent of the downstream protein kinases chk1(+) and cds1(+). Genetics. 152:1501–12.
Matuoka, K., and K.Y. Chen. 2002. Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents. Biogerontology. 3:365–72.
McEachern, M.J., and E.H. Blackburn. 1996. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1822–34.
Meyerson, M., C. Counter, E. Eaton, L. Ellisen, P. Steiner, S. Caddle, L. Ziaugra, R. Beijersbergen, M. Davidoff, Q. Liu, S. Bacchetti, D. Haber, and R. Weinberg. 1997. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumour cells and during immortalization. Cell. 90:785–795.
Mieczkowski, P.A., J.O. Mieczkowska, M. Dominska, and T.D. Petes. 2003. Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc Natl Acad Sci U S A. 100:10854–9.
Mills, K.D., D.A. Sinclair, and L. Guarente. 1999. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell. 97:609–20.
Mitchell, J.R., E. Wood, and K. Collins. 1999. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 402:551–5.
Modrich, P., and R. Lahue. 1996. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 65:101–33.
Morin, G.B. 1989. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell. 59:521–9.
Morin, G.B. 1991. Recognition of a chromosome truncation site associated with alpha-thalassaemia by human telomerase. Nature. 353:454–6.
Myung, K., C. Chen, and R.D. Kolodner. 2001. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Nature. 411:1073–6.
Myung, K., G. Ghosh, F.J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E.A. Hendrickson. 2004. Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86. Mol Cell Biol. 24:5050–9.
Naito, T., A. Matsuura, and F. Ishikawa. 1998. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat Genet. 20:203–6.
Nakamura, T., G. Morin, K. Chapman, S. Weinrich, W. Andrews, J. Lingner, C. Harley, and T. Cech. 1997. Telomerase catalytic subunit homologs from fission yeast and humans. Science. 15:955–959.
Nakamura, T.M., B.A. Moser, and P. Russell. 2002. Telomere binding of checkpoint sensor and DNA repair proteins contributes to maintenance of functional fission yeast telomeres. Genetics. 161:1437–52.
Niida, H., T. Matsumoto, H. Satoh, M. Shiwa, Y. Tokutake, Y. Furuichi, and Y. Shinkai. 1998. Severe growth defect in mouse cells lacking the telomerase RNA component. Nat Genet. 19:203–6.
Nugent, C.I., G. Bosco, L.O. Ross, S.K. Evans, A.P. Salinger, J.K. Moore, J.E. Haber, and V. Lundblad. 1998. Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr Biol. 8:657–60.
Nugent, C.I., T.R. Hughes, N.F. Lue, and V. Lundblad. 1996. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science. 274:249–52.
Olovnikov, A.M. 1996. Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol. 31:443–8.
Parrinello, S., E. Samper, A. Krtolica, J. Goldstein, S. Melov, and J. Campisi. 2003. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 5:741–7.
Peterson, S.E., A.E. Stellwagen, S.J. Diede, M.S. Singer, Z.W. Haimberger, C.O. Johnson, M. Tzoneva, and D.E. Gottschling. 2001. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat Genet. 27:64–7.
Petrini, J.H. 2000. The Mre11 complex and ATM: collaborating to navigate S phase. Curr Opin Cell Biol. 12:293–6.
Plentz, R.R., M. Caselitz, J.S. Bleck, M. Gebel, P. Flemming, S. Kubicka, M.P. Manns, and K.L. Rudolph. 2004. Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology. 40:80–6.
Plentz, R.R., S.U. Wiemann, P. Flemming, P.N. Meier, S. Kubicka, H. Kreipe, M.P. Manns, and K.L. Rudolph. 2003. Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer. Gut. 52:1304–7.
Porter, S.E., P.W. Greenwell, K.B. Ritchie, and T.D. Petes. 1996. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res. 24:582–5.
Ranganathan, V., W.F. Heine, D.N. Ciccone, K.L. Rudolph, X. Wu, S. Chang, H. Hai, I.M. Ahearn, D.M. Livingston, I. Resnick, F. Rosen, E. Seemanova, P. Jarolim, R.A. DePinho, and D.T. Weaver. 2001. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol. 11:962–6.
Ray, A., and K.W. Runge. 1998. The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation. Mol Cell Biol. 18:1284–95.
Ray, A., and K.W. Runge. 1999. Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells. Proc Natl Acad Sci U S A. 96:15044–9.
Reaper, P.M., F. di Fagagna, and S.P. Jackson. 2004. Activation of the DNA damage response by telomere attrition: a passage to cellular senescence. Cell Cycle. 3:543–6.
Reichenbach, P., M. Hoss, C.M. Azzalin, M. Nabholz, P. Bucher, and J. Lingner. 2003. A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr Biol. 13:568–74.
Rezler, E.M., D.J. Bearss, and L.H. Hurley. 2003. Telomere inhibition and telomere disruption as processes for drug targeting. Annu Rev Pharmacol Toxicol. 43:359–79.
Ritchie, K.B., J.C. Mallory, and T.D. Petes. 1999. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol. 19:6065–75.
Ritchie, K.B., and T.D. Petes. 2000. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. Genetics. 155:475–9.
Rizki, A., and V. Lundblad. 2001. Defects in mismatch repair promote telomerase-independent proliferation. Nature. 411:713–6.
Romanov, S.R., B.K. Kozakiewicz, C.R. Holst, M.R. Stampfer, L.M. Haupt, and T.D. Tlsty. 2001. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 409:633–7.
Rudolph, K.L., S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, C. Greider, and R.A. DePinho. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96:701–12.
Rudolph, K.L., S. Chang, M. Millard, N. Schreiber-Agus, and R.A. DePinho. 2000. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science. 287:1253–8.
Rudolph, K.L., M. Millard, M.W. Bosenberg, and R.A. DePinho. 2001. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet. 28:155–9.
Samper, E., J. Flores, and M. Blasco. 2001. Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/-mice with short telomeres. EMBO Rep. 2:800–7.
Samper, E., F.A. Goytisolo, P. Slijepcevic, P.P. van Buul, and M.A. Blasco. 2000. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1:244–52.
Satyanarayana, A., R.A. Greenberg, S. Schaetzlein, J. Buer, K. Masutomi, W.C. Hahn, S. Zimmermann, U. Martens, M.P. Manns, and K.L. Rudolph. 2004a. Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signalling. Mol Cell Biol. 24:5459–74.
Satyanarayana, A., M. Manns, and K. Rudolph. 2004b. Telomeres and Telomerase: A dual role in hepatocarcinogenesis. Hepatology. 40:276–283.
Satyanarayana, A., S.U. Wiemann, J. Buer, J. Lauber, K.E. Dittmar, T. Wustefeld, M.A. Blasco, M.P. Manns, and K.L. Rudolph. 2003. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J. 22:4003–13.
Schaetzlein, S., A. Lucas-Hahn, E. Lemme, W.A. Kues, M. Dorsch, M.P. Manns, H. Niemann, and K.L. Rudolph. 2004. Telomere length is reset during early mammalian embryogenesis. Proc Natl Acad Sci U S A. 101:8034–8.
Schramke, V., P. Luciano, V. Brevet, S. Guillot, Y. Corda, M.P. Longhese, E. Gilson, and V. Geli. 2004. RPA regulates telomerase action by providing Est1p access to chromosome ends. Nat Genet. 36:46–54.
Sedelnikova, O.A., I. Horikawa, D.B. Zimonjic, N.C. Popescu, W.M. Bonner, and J.C. Barrett. 2004. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol. 6:168–70.
Serrano, M., A.W. Lin, M.E. McCurrach, D. Beach, and S.W. Lowe. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88:593–602.
Sharma, G.G., A. Gupta, H. Wang, H. Scherthan, S. Dhar, V. Gandhi, G. Iliakis, J.W. Shay, C.S. Young, and T.K. Pandita. 2003. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene. 22:131–46.
Shay, J.W., and W.E. Wright. 1989. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp Cell Res. 184:109–18.
Shay, J.W., and W.E. Wright. 2005. Telomere-binding factors and general DNA repair. Nat Genet. 37:116–8
Sherr, C.J., and J.M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13:1501–12.
Sherr, C.J., and R.A. DePinho. Cellular senescence: mitotic clock or culture shock? Cell. 102:407–10.
Shiloh, Y. 2000. ATM: sounding the double-strand break alarm. Cold Spring Harb Symp Quant Biol. 65:527–33.
Shiloh, Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 3:155–68.
Shippen-Lentz, D., and E.H. Blackburn. 1990. Functional evidence for an RNA template in telomerase. Science. 247:546–52.
Silva, E., S. Tiong, M. Pedersen, E. Homola, A. Royou, B. Fasulo, G. Siriaco, and S.D. Campbell. 2004. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr Biol. 14:1341–7.
Silverman, J., H. Takai, S.B. Buonomo, F. Eisenhaber, and T. de Lange. 2004. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 18:2108–19.
Smith, J., H. Zou, and R. Rothstein. 2000. Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance. Biochimie. 82:71–8.
Smith, S., and T. de Lange. 2000. Tankyrase promotes telomere elongation in human cells. Curr Biol. 10:1299–302.
Smith, S., I. Giriat, A. Schmitt, and T. de Lange. 1998. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science. 282:1484–7.
Smogorzewska, A., and T. de Lange. 2004. Regulation of telomerase by telomeric proteins. Annu Rev Biochem. 73:177–208.
Smolikov, S., Y. Mazor, and A. Krauskopf. 2004. ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing. Proc Natl Acad Sci U S A. 101:1656–61.
Stansel, R.M., T. de Lange, and J.D. Griffith. 2001. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20:5532–40.
Stein, G.H., L.F. Drullinger, A. Soulard, and V. Dulic. 1999. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol. 19:2109–17.
Stellwagen, A.E., Z.W. Haimberger, J.R. Veatch, and D.E. Gottschling. 2003. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev. 17:2384–95.
Stewart, S.A., I. Ben-Porath, V.J. Carey, B.F. O’Connor, W.C. Hahn, and R.A. Weinberg. 2003. Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet. 33. 492–6.
Stewart, S.A., W.C. Hahn, B.F. O’Connor, E.N. Banner, A.S. Lundberg, P. Modha, H. Mizuno, M.W. Brooks, M. Fleming, D.B. Zimonjic, N.C. Popescu, and R.A. Weinberg. 2002. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A. 99:12606–11.
Takai, H., A. Smogorzewska, and T. de Lange. 2003. DNA damage foci at dysfunctional telomeres. Curr Biol. 13:1549–56.
Takata, H., Y. Kanoh, N. Gunge, K. Shirahige, and A. Matsuura. 2004. Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell. 14:515–22.
Tang, Z.Y., H. Yi, and B.L. Chen. 2001. [Telomerase activity in bladder cancer tissues]. Hunan Yi Ke Da Xue Xue Bao. 26:167–8.
Tarsounas, M., P. Munoz, A. Claas, P.G. Smiraldo, D.L. Pittman, M.A. Blasco, and S.C. West. 2004. Telomere maintenance requires the RAD51D recombination/repair protein. Cell. 117:337–47.
Tong, W.M., M.P. Hande, P.M. Lansdorp, and Z.Q. Wang. 2001. DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumour suppression. Mol Cell Biol. 21:4046–54.
Tsukamoto, Y., J. Kato, and H. Ikeda. 1997. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature. 388:900–3.
van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature. 385:740–3.
van Steensel, B., A. Smogorzewska, and T. de Lange. 1998. TRF2 protects human telomeres from end-to-end fusions. Cell. 92:401–13.
Vaziri, H., and S. Benchimol. 1996. From telomere loss to p53 induction and activation of a DNA damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp Gerontol. 31:295–301.
Venkitaraman, A.R. 2002. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 108:171–82.
von Zglinicki, T., G. Saretzki, W. Docke, and C. Lotze. 1995. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res. 220:186–93.
Vulliamy, T., A. Marrone, F. Goldman, A. Dearlove, M. Bessler, P.J. Mason, and I. Dokal. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 413:432–5.
Wei, C., R. Skopp, M. Takata, S. Takeda, and C.M. Price. 2002. Effects of double-strand break repair proteins on vertebrate telomere structure. Nucleic Acids Res. 30:2862–70.
Wiemann S.U., A. Satyanarayana, J. Buer, K. Kamino, M.P. Manns, K.L. Rudolph. 2005. Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic organ damage. Oncogene.. 24:1501–9.
Wong, J.M., L. Kusdra, and K. Collins. 2002. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol. 4:731–6.
Wong, K.K., S. Chang, S.R. Weiler, S. Ganesan, J. Chaudhuri, C. Zhu, S.E. Artandi, K.L. Rudolph, G.J. Gottlieb, L. Chin, F.W. Alt, and R.A. DePinho. 2000. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 26:85–8.
Wong, K.K., R.S. Maser, R.M. Bachoo, J. Menon, D.R. Carrasco, Y. Gu, F.W. Alt, and R.A. DePinho. 2003. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421:643–8.
Wright, W.E., and J.W. Shay. 1992. The two-stage mechanism controlling cellular senescence and immortalization. Exp Gerontol. 27:383–9.
Wright, W.E., V.M. Tesmer, K.E. Huffman, S.D. Levene, and J.W. Shay. 1997. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11:2801–9.
Wu, X., V. Ranganathan, D.S. Weisman, W.F. Heine, D.N. Ciccone, T.B. O’Neill, K.E. Crick, K.A. Pierce, W.S. Lane, G. Rathbun, D.M. Livingston, and D.T. Weaver. 2000. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature. 405:477–82.
Yan, S.N., B. Deng, and Z.J. Gong. 2003. [Effect of cell cycle on telomerase activity of hepatoma cells and its relationship with replication of hepatitis B virus]. Ai Zheng. 22:504–7.
Yan, Y.L., J.X. Zheng, X. Wang, Y. Wang, and J.Y. Yang. 2002. [Detection of telomerase activity in bronchoscopic brush-off samples in patients with lung cancer]. Ai Zheng. 21:768–71.
Ye, J.Z., D. Hockemeyer, A.N. Krutchinsky, D. Loayza, S.M. Hooper, B.T. Chait, and T. de Lange. 2004. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev. 18:1649–54.
Yuan, X., S. Ishibashi, S. Hatakeyama, M. Saito, J. Nakayama, R. Nikaido, T. Haruyama, Y. Watanabe, H. Iwata, M. Iida, H. Sugimura, N. Yamada, and F. Ishikawa. 1999. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells. 4:563–72.
Zhou, X.Z., and K.P. Lu. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 107:347–59.
Zhu, J., H. Wang, J.M. Bishop, and E.H. Blackburn. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A. 96:3723–8.
Zhu, J., D. Woods, M. McMahon, and J.M. Bishop. 1998. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12:2997–3007.
Zhu, X.D., L. Niedernhofer, B. Kuster, M. Mann, J.H. Hoeijmakers, and T. de Lange. 2003. ERCC1/XPF removes the 3′ overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell. 12:1489–98.
Zou, L., D. Cortez, and S.J. Elledge. 2002. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16:198–208.
Zou, L., and S.J. Elledge. 2003. Sensing DNA damage through ATRIP recognition of RPAssDNA complexes. Science. 300:1542–8.
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Greenberg, R.A., Rudolph, K.L. (2005). Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R., Nigg, E.A. (eds) Genome Instability in Cancer Development. Advances in Experimental Medicine and Biology, vol 570. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3764-3_11
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