Guava (Psidium guajava Linn.) an important fruit of subtropical countries is affected by about 177 pathogens of which, 167 are fungal, 3 bacterial, 3 algal, 3 nematodes and one epiphyte. Wilt is the most important disease of guava. Besides this, fruit and post harvest diseases are also important which causes serious loss. The fruit diseases are of two types i.e. field diseases and post harvest diseases, which develop during transit and storage. Due to it’s perishable nature number of pathogens are reported on fruits which causes different types of rots of guava fruits. In the present communication all major diseases are described with their symptoms, causal organisms and disease management practices.