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The Emerging Science of Drug Abuse Prevention

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Book cover Handbook of Drug Abuse Prevention

Part of the book series: Handbooks of Sociology and Social Research ((HSSR))

Abstract

In summary, the field of drug abuse prevention has emerged over the past 15 years as a credible scientific discipline that has produced significant understanding of the underlying psychosocial risks and protective factors associated with drug use onset and progression to abuse. In addition, evidence from randomized controlled trials and quasi-experimental studies of theory-based drug abuse prevention interventions indicates that a growing number of drug abuse prevention programs and policies have demonstrated efficacy in reducing risks and moderating drug abuse behaviors of youths provided the programs in comparison to controls. Based upon this body of research, drug abuse prevention principles have been developed and applied in the practice community. Finally, the field of prevention science is beginning to address the important research questions associated with taking evidence-based drug abuse prevention programs and policies to scale in the prevention practice system at the state and community level.

However, numerous barriers to the continued advance of drug abuse prevention science need to be addressed and resolved. Research indicates that the vast majority of schools still use un-evaluated drug abuse prevention programs or use prevention programs that do not have strong research evidence to support their efficacy. In addition, it is clear from the research that current evidence-based drug abuse prevention programs are not targeting the youth and adolescents at high risk to drug use onset and progression to abuse. To address this problem and to substantially increase the effectiveness (effect sizes) of prevention intervention programs, it is recommended by several national research reports that a new generation of prevention interventions to address a number of behavioral health problems need to be designed and tested and that these interventions integrate our scientific knowledge across multiple disciplines to include neurobiological, behavioral, and prevention sciences. Through a better understanding of the interactions between genetic, neurobiological, and psychosocial risk and protective factors, it is proposed that more effective “targeted” prevention interventions can be developed to reach our hardest to reach groups nationwide. Several examples of how this new generation of drug abuse prevention research could be developed have been provided in this chapter to guide future thinking and planning activities.

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References

  • Allen, N. B., Lewinshon, P. M., & Seeley, J. R. (1998). Prenatal and perinatal influences on risk for psychopathology in childhood and adolescence. Developmental Psychopathology, 10, 513–529.

    Article  Google Scholar 

  • Arnold, C., Kuller, L., & Greenlick, M. (1981). Advances in disease prevention. New York: Springer.

    Google Scholar 

  • Bangert-Drowns, R. (1988). The effects of school-based substance abuse education—A meta-analysis. Journal of Drug Education, 18(3), 243–264.

    Google Scholar 

  • Brook, J. S., Brook, D. W., & Whiteman, M. (2000). The influence of maternal smoking during pregnancy on the toddlers negativity. Archives of Pediatric and Adolescent Medicine, 154(4), 381–385.

    Google Scholar 

  • Brooks-Gunn, J., McCarton, C., & Hawley, T. (1994). Effects of in utero drug exposure on children’s development: Review and recommendations. Archives of Pediatric and Adolescent Medicine, 148, 33–39.

    Google Scholar 

  • Buchner, J. C., & Cain, A. C. (1998). Prevention science research with children, adolescents, and families: Introduction. American Journal of Orthopsychiatry, 68(4), 508–511.

    Article  Google Scholar 

  • Bukoski, W. J. (1991). A definition of drug abuse prevention research. In L. Donohew, H. E. Sypher, & W. J. Bukoski (Eds.), Persuasive communication and drug abuse prevention (pp. 3–21). NJ: Lawrence Erlbaum Associates.

    Google Scholar 

  • Bukoski, W. J. (1997). Meta-analysis of drug abuse prevention programs. NIDA Research Monograph 170. No. 97-4146. Bethesda, MD: National Institute on Drug Abuse.

    Google Scholar 

  • Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998). Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proceedings of the National Academy of Sciences, 95, 3752–3757.

    Article  Google Scholar 

  • Cicchetti, D., Rogosch, F. A., Toth, S. L., & Spagnola, M. (1997). Affect, cognition, and the emergence of self-knowledge in the toddler offspring of depressed mothers. Journal of Experimental Child Psychology, 67, 338–362.

    Article  Google Scholar 

  • Coie, J. D., Watt, N. F., West, S. G., Hawkins, J. D., Asarnow, J. R., Markman, H. J., Ramey, S. L., Shure, M. B., & Long, B. (1993). The science of prevention: A conceptual framework and some directions for a national research program. American Psychologist, 48(10), 1013–1022.

    Article  Google Scholar 

  • Durlak, J. A., & Wells, A. (1998). Evaluation of indicated prevention intervention (secondary prevention) mental health programs for children and adolescents. American Journal of Community Psychology, 26(5), 775–802.

    Article  Google Scholar 

  • Fishbein, D. (2000). The importance of neurobiological research to the prevention of psychopathology. Prevention Science, 2, 89–106.

    Article  Google Scholar 

  • Fisher, P. A., Gunnar, M. R., Chamberlain, P., & Reid, J. B. (2000). Preventive intervention for maltreated preschoolers: Impact on children’s behavior, neuroendrocrine activity, and foster parent functioning. Journal of the American Academy of Child and Adolescent Pschiatry, 39(11), 1356–1364.

    Article  Google Scholar 

  • Fleming, A. S., O’Day, D. H., & Kraemer, G. W. (1999). Neurobiology of mother-infant interactions: Experiences and central nervous system plasticity across development and generations. Neuroscience Biobehavior Review, 23, 673–685.

    Article  Google Scholar 

  • Fletcher, J. M. (2001). Prevention of reading disabilities. Proceedings from the 9th Annual Meeting, Society for Prevention Research. Washington, DC, May 31–June 2.

    Google Scholar 

  • Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999). Nongenetic Transmission across generations of maternal behavior and stress response in the rat. Science, 286, 1155–1158.

    Article  Google Scholar 

  • Garmezy, N. (1985). Stress-resistant children: The search for protective factors. In J. E. Stevenson (Ed.), Recent research in developmental psychopathology (pp. 213–233). Journal of Child Psychology and Psychiatry, 4 (Book supplement).

    Google Scholar 

  • Giancola, P. R., & Moss, H. B. (1998). Executive cognitive functioning in alcohol use disorder. In M. Galanter (Ed.), Recent Developments in Alcoholism (14) (pp. 227–251). New York: Plenum Press.

    Chapter  Google Scholar 

  • Giancola, P. R., & Tarter, R. E. (1999). Executive cognitive functioning and risk for substance abuse. Psychological Science, 10(3), 203–205.

    Article  Google Scholar 

  • Glantz, M. D., & Johnson, J. L. (1999). Resilience and development—Positive life adaptations. New York: Kluwer Academic/Plenum Publishers.

    Google Scholar 

  • Glantz, M. D., & Pickens, R. W. (Eds., 1992). Vulnerability to drug abuse. Washington, DC: American Psychological Association.

    Google Scholar 

  • Glover, V. (1997). Maternal stress or anxiety in pregnancy and emotional development of the child. British Journal of Psychiatry, 171, 105–106.

    Article  Google Scholar 

  • Goodman, S. H., & Gotlib, I. H. (1999). Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychology Review, 106, 458–490.

    Article  Google Scholar 

  • Griffin, K. W., Botvin, G. J., Scheier, L. M., Diaz, T., & Miller, N. (2000b). Parenting practices as predictors of substance use, delinquency, and aggression among urban minority youth: Moderating effects of family structure and gender. Psychology of Addictive Behaviors, 14(2), 174–184.

    Article  Google Scholar 

  • Griffin, K. W., Scheier, L. M., Botvin, G. J., & Diaz, T. (2000a). Ethnic and gender differences in psychosocial risk, protection, and adolescent alcohol use. Prevention Science, 1(4), 199–212.

    Article  Google Scholar 

  • Guerra, C. (1998). Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure. Alcohol Clinical and Experimental Research, 22, 304–312.

    Article  Google Scholar 

  • Hawkins, J. D., & Catalano, R. F. (1992). Communities that care. San Francisco: Jossey-Bass.

    Google Scholar 

  • Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin, 112(1), 64–105.

    Article  Google Scholar 

  • Ito, Y., Teicher, M. H., Glod, C. A., & Ackerman, E. (1998). Preliminary evidence for aberrant cortical development in abused children: A quantitative EEG study. Journal of Neuropsychiatry and Clinical Neuroscience, 10(3), 298–307.

    Google Scholar 

  • Kandel, E. R. (1998). A new intellectual framework for psychiatry. The American Journal of Psychiatry, 155(4), 457–469.

    Google Scholar 

  • Kaufer, D., Friedman, A., Seidman, S., & Soreq, H. (1998). Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature, 393, 373–377.

    Article  Google Scholar 

  • Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience, 18(9), 3206–3212.

    Google Scholar 

  • Kendler, K. S., Neale, M. C., Sullivan, P., Corey, L. A., Gardner, C. O., & Prescott, C. A. (1999). A population-based twin study in women of smoking initiation and nicotine dependence. Psychological Medicine, 29(2), 299–308.

    Article  Google Scholar 

  • Kuhn, C. M., & Schanberg, S. M. (1998). Responses to maternal separation: Mechanisms and mediators. International Journal of Developmental Neuroscience, 16, 261–270.

    Article  Google Scholar 

  • Ladd, C. O., Owens, M. J., & Nemcroff, C. B. (1996). Persistent changes in corticotropin-releasing factor neural systems induced by maternal deprivation. Endocrinology, 137(4), 1212–1218.

    Article  Google Scholar 

  • Lewis, D. O. (1992). From abuse to violence: Psychophysiological consequences of maltreatment. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 383–391.

    Article  Google Scholar 

  • Leshner, A. I. (1997). Addiction is a brain disease, and it matters. Science, 278 (October 3), 45–47.

    Article  Google Scholar 

  • Leshner, A. I. (1999a). Institute will expand research into the interaction of genetics and environment in vulnerability to drug abuse and addiction. NIH Publication No. 99-3478. NIDA Notes, 13(6), 3–4, 12.

    Google Scholar 

  • Leshner, A. I. (1999b). Science-based views of drug addiction and its treatment. The Journal of the American Medical Association, 282 (October 13), 1314–1316.

    Article  Google Scholar 

  • Lezak, M. (1995). Neuropsychological assessment. New York: Oxford University Press.

    Google Scholar 

  • Lou, H. C., Hansen, D., Nordenfoft, M, Pryds, O., Jensen, F., Nim, J., & Hemmingsen, R. (1994). Prenatal stressors of human life affect fetal brain development. Developmental Medicine and Child Neurology, 36, 826–832.

    Article  Google Scholar 

  • Lui, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal response to stress. Science, 277, 1659–1662.

    Article  Google Scholar 

  • McEwen, B. S. (1998). Protective and damaging effects of mediators of stress. New England Journal of Medicine, 338, 171–179.

    Article  Google Scholar 

  • McGue, M. (1994). Genes, environment, and the etiology of alcoholism. In R. Zucker, G. Boyd, & J. Howard (Eds.), The development of alcohol problems: Exploring the biopsychosocial matrix (pp. 1–39). Research Monograph No. 26. Rockville, MD: National Institute of Alcohol Abuse and Alcoholism, U.S. Department of Health, Human Services.

    Google Scholar 

  • Meaney, M. J., Mitchell, J. B., Aitken, D. H., Bhatnagar, S, Bodnoff, S. R., Iny, L. J., & Sarrieau, A. (1991). The effects of neonatal handling on the development of the adrenocortical response to stress: Implications for neuropathology and cognitive deficits in later life. Psychoneuroendocrinology, 16, 85–103.

    Article  Google Scholar 

  • Merikangas, K. R., & Avenevoli, S. (2000). Implications of genetic epidemiology for the prevention of substance use disorders. Addictive Behaviors, 25(6), 807–820.

    Article  Google Scholar 

  • Merikangas, K. R., Dierker, L. C., & Szatmari, P. (1998). Psychopathology among offspring of parents with substance abuse and/or anxiety: A high risk study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 39, 711–720.

    Google Scholar 

  • Merikangas, K. R., Stolar, D. E., Stevens, D. E., Goulet, J., Preisig, M., Fenton, B., O’Malley, S., & Rounsaville, B. J. (1998). Familial transmission of substance use disorders. Archives of General Psychiatry, 55, 973–979.

    Article  Google Scholar 

  • Mihalic, S., Irwin, K., Elliot, D., Fagan, A., & Hansen, D. (2001). Blueprints for violence prevention. Juvenile Justice Bulletin. Washington, DC: Office of Juvenile Justice and Delinquency Prevention.

    Google Scholar 

  • Moss, H. B., Vanyukov, M., Yao, J. K., & Kirillova, G. P. (1999). Biological Psychiatry, 45(10), 1293–1299.

    Article  Google Scholar 

  • Mrazek, P. J., & Haggerty, R. J. (1994). Reducing risks for mental disorders. Washington, DC: National Academy Press.

    Google Scholar 

  • National Institute on Drug Abuse (1997). Preventing drug use among children and adolescents: A research-based guide. NIH Publication No. 97-4212. Bethesda, MD: National Institute on Drug Abuse.

    Google Scholar 

  • National Institute on Drug Abuse (1999). Drug abuse and addiction research: The sixth triennial report to congress from the secretary of health and human services. Bethesda, MD: National Institute on Drug Abuse.

    Google Scholar 

  • National Institutes of Health (1998). Preventive intervention research at the crossroads: Contributions and opportunities from the behavioral and social sciences—Conference proceedings. Bethesda, MD: National Institutes of Health.

    Google Scholar 

  • Nestler, E. J., & Aghajanian, G. K. (1997). Molecular and cellular basis of addiction. Science, 278 (October 3), 58–63.

    Article  Google Scholar 

  • Nestler, E. J., & Landsman, D. (2001). Learning about addiction from the genome. Nature, 409 (February), 834–835.

    Article  Google Scholar 

  • Newcomb, M.D. (1997). Psychosocial predictors and consequences of drug use: A developmental perspective within a prospective study. Journal of Addictive Disease, 16(1), 51–89.

    Article  Google Scholar 

  • Office of National Drug Control Policy (1999a). The national drug control strategy: 1999. Washington, DC: Superintendent of Documents, U.S. Government Printing Office.

    Google Scholar 

  • Office of National Drug Control Policy (1999b). The national drug control strategy, 1999 budget summary. Washington, DC: Superintendent of Documents, U.S. Government Printing Office.

    Google Scholar 

  • Office of National Drug Control Policy (2001). The national drug control strategy: 2001 annual report. Washington, DC: Superintendent of Documents, U.S. Government Printing Office.

    Google Scholar 

  • Pellmar, T. C., & Eisenberg, L. (2000). Bridging disciplines in the brain, behavioral, and clinical sciences. Institute of Medicine, Washington, DC: National Academy Press.

    Google Scholar 

  • Pham, T. M., Doderstrom, S., Henriksson, B. G., & Mohammed, A. H. (1997). Effects of neonatal stimulation on later cognitive function and hippocampal nerve growth factor. Behavioral Brain Research, 86, 113–120.

    Article  Google Scholar 

  • Plotsky, P. M., & Meaney, M. J. (1993). Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Molecular Brain Research, 18, 195–200.

    Article  Google Scholar 

  • Posey, S., Wong, S. C., Catalano, R. F., Hawkins, J. D., Dusenbury, L., & Chappell, P. J. (2000). Communities that care prevention strategies: A research guide to what works. Seattle, WA: Development Research and Programs.

    Google Scholar 

  • Reiss, D., Hetherinton, E. M., Plomin, R., Howe, G. W., Simmens, S. J., Henderson, S. H., O’Connor, T. J., Bussell, D. A., Anderson, E. R., & Law, T. (1995). Genetic questions for environmental studies: Differential parenting and psychopathology in adolescence. Archives of General Psychiatry, 52, 925–936.

    Google Scholar 

  • Reiss, D., & Neiderhiser, J. M. (2000). The interplay of genetic influences and social processes in developmental theory: Specific mechanisms are coming into view. Development and Psychopathology, 12(3), 357–374.

    Article  Google Scholar 

  • Roberts, J. M., & Redman, C. W. (1993). Pre-eclampsia: More than pregnancy-induced hypertension. Lancet, 341, 1447–1451.

    Article  Google Scholar 

  • Rutter, M. (1985). Resilience in the face of adversity: Protective factors and resistance to psychiatric disorder. British Journal of Psychiatry, 147, 598–611.

    Article  Google Scholar 

  • Sattar, N., Greer, I. A., Galloway, P. J., Packard, C. J., Shephard, J., Kelly, T., & Mathers, A. (1999). Lipid and lipoprotein concentration in pregnancies complicated by intrauterine growth restriction. Journal of Clinical Endocrinology and Metabolism, 84, 128–130.

    Article  Google Scholar 

  • Scheier, L. M., Botvin, G. J., Diaz, T., & Griffin, K. (1999). Social skills, competence, and drug refusal efficacy as predictors of adolescent alcohol use. Journal of Drug Education, 29(3), 251–278.

    Article  Google Scholar 

  • Scheier, L. M., Botvin, G. J., Griffin, K. W., & Diaz, T. (2000). Dynamic growth models of self-esteem and adolescent alcohol use. Journal of Early Adolescence, 20(2), 178–209.

    Article  Google Scholar 

  • Senba, E., & Ueyama, T. (1997). Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat. Neuroscience Research, 29, 183–207.

    Article  Google Scholar 

  • Silvia, E. S., Thorne, J., & Tashjian, C. A. (1997). School-based drug prevention programs: A longitudinal study in selected school districts. Final report (Contract No. LC90070001). Washington, DC: U.S. Department of Education.

    Google Scholar 

  • Simos, P. G., Fletcher, J. M., Bergman, E., Breier, J. I., Foorman, B. R., Castillo, E. M. Davis, R. N., Fitzgerald, M., & Pananicolaou, A. C. (2002). Dyslexia-specific brain activation profile becomes normal following successful remedial training. Neurology, 58, 1203–1213.

    Google Scholar 

  • Singer, B. H., & Ryff, C. D. (Eds., 2001). New horizons in health: An integrative approach. National Research Council, Washington, DC: National Academy Press.

    Google Scholar 

  • Smeriglio, V.L., & Wilcox, H. C. (1999). Prenatal drug exposure and child outcome. Clinics in Perinatology, 26(1), 1–16.

    Google Scholar 

  • Sokolowski, M. B., & Wahlstein, D. (2001). Gene-environment interaction and complex behavior. In H. R. Chin & S. O. Moldin (Eds.), Methods in genomic neuroscience. Boca Raton, FL: CRC Press.

    Google Scholar 

  • Tobler, N. S., Roona, M. R., Ochshorn, P., Marshall, D. G., Streke, A. V., & Stackpole, K. M. (2000). School-based adolescent drug prevention programs: 1998 meta-analysis. The Journal of Primary Prevention, 20(4), 275–336.

    Article  Google Scholar 

  • True, W., & Xian, H. (1999). Common genetic vulnerability for nicotine and alcohol dependence in men. Archives of General Psychiatry, 56(7), 655–661.

    Article  Google Scholar 

  • U.S. Department of Health and Human Services (2001). Youth violence: A report of the surgeon general. Rockville, MD: U.S. Department of Health and Human Services.

    Google Scholar 

  • Wakschlag, L. S., Lahey, B. B., Loeber, R., Green, S. M. Gordon, J. R., & Leventhal, B. L. (1997). Maternal smoking during pregnancy and the risk of conduct disorder in boys. Archives of General Psychiatry, 54(7), 670–676.

    Google Scholar 

  • Wickelgren, I. (1997). Getting the brain’s attention. Science, 278 (October 3), 35–37.

    Article  Google Scholar 

  • Wilner, D., Walkley, R., & O’Neil, E. (1978). Introduction to public health (7th ed.), New York: MacMillan.

    Google Scholar 

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Bukoski, W.J. (2006). The Emerging Science of Drug Abuse Prevention. In: Sloboda, Z., Bukoski, W.J. (eds) Handbook of Drug Abuse Prevention. Handbooks of Sociology and Social Research. Springer, Boston, MA. https://doi.org/10.1007/0-387-35408-5_1

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