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8. References
A.D. Beyers, L.L. Spruyt, and A.F. Williams, Molecular associations between the Tlymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5, Proc. Natl. Acad. Sci. USA, 89, 2945–2949 (1992).
C. Montixi, C. Langlet, A.M. Bernard, J. Thimonier, C. Dubois, M.A. Wurbel, J.P. Chauvin, M. Pierres, and H.T. He. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains, EMBO J., 17, 5334–5348 (1998).
R. Xavier, T. Brennan, Q. Li, C. McCormack, and B. Seed, Membrane compartmentation is required for efficient T cell activation, Immunity, 8, 723–732 (1998).
K. Simons, and E. Ikonen, Functional rafts in cell membranes, Nature, 387, 569–572 (1997).
D.A. Brown, and E. London, Functions of lipid rafts in biological membranes, Annu. Rev. Cell Dev. Biol., 14, 111–136 (1998).
P.S. Kabouridis, A.I. Magee, and S.C. Ley, S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes, EMBO J., 16, 4983–4998 (1997).
R.D. Klausner, A.M. Kleinfeld, R.L. Hoover, and M.J. Karnovsky, Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis, J. Biol. Chem., 255, 1286–1295 (1980).
D.A. Brown, and J.K. Rose, Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface, Cell, 68, 533–544 (1992).
R.J. Schroeder, S.N. Ahmed, Y. Zhu, E. London, and D.A. Brown, Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositolanchored proteins by promoting the formation of detergent-insoluble ordered membrane domains, J Biol Chem, 273, 1150–1157 (1998).
S. Munro, Lipid Rafts: Elusive or Illusive? Cell, 115,377 (2003).
H. Heerklotz, Triton promotes domain formation in lipid raft mixtures, Biophys. J. 83, 2693–701 (2002).
S. Schuck, M. Honsho, K. Ekroos, A. Shevchenko, and K. Simons, Resistance of cell membranes to different detergents, Proc. Natl. Acad. Sci. USA, 100, 5795–800 (2003).
R.J. Schroeder, S.N. Ahmed, Y. Zhu, E. London, and D.A. Brown, Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositolanchored proteins by promoting the formation of detergent-insoluble ordered membrane domains, J. Biol. Chem., 273, 1150–1157 (1998).
A. Pralle, P. Keller, E.L. Florin, K. Simons, and J.K. Horber, Sphingolipidcholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells, J. Cell Biol., 148, 997–1008 (2000).
T. Harder, P. Scheiffele, P. Verkade, and K. Simons, Lipid domain structure of the plasma membrane revealed by patching of membrane components, J. Cell Biol., 141, 929–942 (1998).
S. Manes, E. Mira, C. Gomez-Mouton, R.A. Lacalle, P. Keller, J.P. Labrador, and A.C. Martinez, Membrane raft microdomains mediate front-rear polarity in migrating cells, EMBO J., 18, 6211–6220 (1999).
A.K. Kenworthy, N. Petranova, and M. Edidin, High-resolution FRET microscopy of cholera toxin B-subunit and GPI-anchored proteins in cell plasma membranes, Mol. Biol. Cell, 11, 1645–1655 (2000).
R. Varma, and S. Mayor, GPI-anchored proteins are organized in submicron domains at the cell surface, Nature, 394, 798 (1998).
D.A. Zacharias, J.D. Violin, A.C. Newton, and R.Y. Tsien, Partitioning of lipidmodified monomeric GFPs into membrane microdomains of live cells, Science, 296, 913–916 (2002).
P. Sharma, R. Varma, R.C. Sarasij, Ira, K. Gousset, G. Krishnamoorthy, M. Rao, and S. Mayor, Nanoscale organization of multiple GPI-anchored proteins in living cell membranes, Cell, 116, 577 (2004).
D.E. Shvartsman, M. Kotler, R.D. Tall, M.G. Roth, and Y.I. Henis, Differently anchored influenza hemagglutinin mutants display distinct interaction dynamics with mutual rafts, J. Cell Biol., 163, 879–888 (2003).
A.K. Kenworthy, B.J. Nichols, C.L. Remmert, G.M. Hendrix, M. Kumar, J. Zimmerberg, and J. Lippincott-Schwartz, Dynamics of putative raft-associated proteins at the cell surface, J. Cell Biol., 165, 735–746 (2004).
G.J. Schutz, G. Kada, V.P. Pastushenko, and H. Schindler, Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy, EMBO J, 19, 892–901 (2000).
C. Dietrich, B. Yang, T. Fujiwara, A. Kusumi, and K. Jacobson, Relationship of lipid rafts to transient confinement zones detected by single particle tracking, Biophys. J., 82, 274–284 (2002).
T. Fujiwara, K. Ritchie, H. Murakoshi, K. Jacobson, and A. Kusumi, Phospholipids undergo hop diffusion in compartmentalized cell membrane, J. Cell Biol., 157, 1071–1082 (2002).
G.J. Schutz, H. Schindler, and T. Schmidt, Single-molecule microscopy on model membranes reveals anomalous diffusion, Biophys. J., 73, 1073–1080 (1997).
A.D. Douglass, and R.D. Vale, Single-Molecule Microscopy Reveals Plasma Membrane Microdomains Created by Protein-Protein Networks that Exclude or Trap Signaling Molecules in T Cells, Cell, 121, 937–950 (2005).
M.L. Dustin, M.W. Olszowy, A.D. Holdorf, J. Li, S. Bromley, N. Desai, P. Widder, F. Rosenberger, P.A. van der Merwe, P.M. Allen, and A.S. Shaw, A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts, Cell, 94, 667–677 (1998).
W. Zhang, R.P. Trible, and L.E. Samelson, LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation, Immunity, 9, 239–246 (1998).
T. Brdicka, D. Pavlistova, A. Leo, E. Bruyns, V. Korinek, P. Angelisova, J. Scherer, A. Shevchenko, I. Hilgert, J. Cerny, K. Drbal, Y. Kuramitsu, B. Kornacker, V. Horejsi, and B. Schraven, Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation, J. Exp. Med., 191, 1591–1604 (2000).
D. Filipp, J. Zhang, B.L. Leung, S. Shaw, S.D. Levin, A. Veillette, and M. Julius, Regulation of Fyn through translocation of activated Lck into lipid rafts, J. Exp. Med., 197, 1221–1227 (2003).
P. Pizzo, E. Giurisato, A. Bigsten, M. Tassi, R. Tavano, A. Shaw, and S. Viola, Physiological T cell activation starts and propagates in lipid rafts, Immunol. Lett., 91, 3–9 (2004).
M. Zhu, S. Shen, Y. Liu, O. Granillo, and W. Zhang, Cutting edge: localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development, J. Immunol., 174, 31–35 (2005).
S. Valitutti, M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia, Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton, J. Exp. Med., 181, 577–584 (1995).
M. Moran, and M.C. Miceli, Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: a role for lipid rafts in T cell activation, Immunity, 9, 787–796 (1998).
E. Giurisato, D.P. McIntosh, M. Tassi, A. Gamberucci, and A. Benedetti, T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering, J. Biol. Chem., 278, 6771–6778 (2003).
P. Drevot, C. Langlet, X.J. Guo, A.M. Bernard, O. Colard, J.P. Chauvin, R. Lasserre, and H.T. He, TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts, EMBO J., 21, 1899–1908 (2002).
P. Munoz, M.D. Navarro, E.J. Pavon, J. Salmeron, F. Malavasi, J. Sancho, and M. Zubiaur, CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor, J. Biol. Chem., 278, 50791–50802 (2003).
R. Xavier, and B. Seed, Membrane compartmentation and the response to antigen, Curr. Opin. Immunol., 11, 265–269 (1999).
J. Mestas, and C.C.W. Hughes, Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation, J. Immunol., 167, 4378–4385 (2001).
Y. Yashiro-Ohtani, X.Y. Zhou, K. Toyo-Oka, X.G. Tai, C.S. Park, T. Hamaoka, R. Abe, K. Miyake, and H. Fujiwara, Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts, J. Immunol., 164, 1251–1259 (2000).
A. Viola, S. Schroeder, Y. Sakakibara, and A. Lanzavecchia, T lymphocyte costimulation mediated by reorganization of membrane microdomains, Science, 283, 680–682 (1999).
C. Wulfing, and M.M. Davis, A receptor/cytoskeletal movement triggered by costimulation during T cell activation, Science, 282, 2266–2269 (1998).
A. Arcaro, C. Gregoire, T.R. Bakker, L. Baldi, M. Jordan, L. Goffin. N. Boucheron, f. Wurm, P.A. van der Merwe, B. Malissen, and I.F. Luescher, CD8beta endows cd8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56lck complexes, J. Exp. Med., 194, 1485–1495 (2001).
G.M. Bell, J. Fargnoli, J.B. Bolen, L. Kish, and J.B. Imboden, The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2, J. Exp. Med., 183, 169–178 (1996).
A.M. Carmo, D.W. Mason, and A.D. Beyers, Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn, Eur. J. Immunol., 23, 2196–2201 (1993).
A.M. Carmo, R.J. Nunes, M. Bamberger, A.R. Maia, M.I. Oliveira, and M.A.A. Castro, Lck-dependent and independent mechanisms in the activation-induced translocation of T lymphocyte accessory molecules to lipid rafts, FASEB J., 19(Part 1 Suppl. S), A389 (2005).
L. Kuerschner, C.S. Ejsing, K. Ekroos, A. Shevchenko, K.I. Anderson, and C. Thiele, Polyene-lipids: a new tool to image lipids, Nat. Methods, 2, 39–45 (2005).
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Nunes, R.J., Castro, M.A.A., Carmo, A.M. (2006). Protein Crosstalk in Lipid Rafts. In: Tsoukas, C. (eds) Lymphocyte Signal Transduction. Advances in Experimental Medicine and Biology, vol 584. Springer, Boston, MA. https://doi.org/10.1007/0-387-34132-3_10
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