Abstract
The dorsal-ventral patterning of the telencephalon is crucial for normal brain function because it determines the proportion of two different basic types of neurons: glutamatergic excitatory neurons and GABAergic inhibitory neurons. The secreted protein sonic hedgehog (Shh) is required for ventral cell specification, whereas the zinc finger transcription factor Gli3 seems to be important for dorsal cell type specification. Recent studies suggest how both Gli3 and Shh control the normal proportion of dorsal and ventral cell types to generate appropriate tissue size and shape. These observations may offer new insights into our understanding of the graded function of Shh during brain development.
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Motoyama, J., Aoto, K. (2006). Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon. In: Hedgehog-Gli Signaling in Human Disease. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-33777-6_14
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DOI: https://doi.org/10.1007/0-387-33777-6_14
Publisher Name: Springer, Boston, MA
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