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BK Virus Infection after Non-Renal Transplantation

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Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

Infection with BK virus (BKV), a member of the Polyomavirus (PV) family, is ubiquitous, with the virus remaining in a latent form in the kidney and urinary tract.1, 2 This infection is usually asymptomatic, but with impairment of the cellular immune system the virus can reactivate and lead to tissue damage. In recipients of bone marrow and solid organ transplants, PV reactivation can be associated with disease in urinary tract and kidneys. BKV was first discovered in 1971 from the urine of a kidney transplant recipient who had developed ureteral stenosis 4 months after transplantation. While much of the subsequent research focuses on patients after renal transplantation, we will review PV impact in patients after bone marrow transplant (BMT) and those with non-renal solid organ transplants.

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Author information

Authors and Affiliations

  1. Beth Israel Deaconess Hospital, Boston, Massachusetts, USA

    Martha Pavlakis M.D.

  2. Wayne State University, Detroit, Michigan, USA

    Abdolreza Haririan M.D.

  3. University of Maryland School of Medicine, Baltimore, Maryland, USA

    David K. Klassen M.D.

Authors
  1. Martha Pavlakis M.D.
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  2. Abdolreza Haririan M.D.
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  3. David K. Klassen M.D.
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Editor information

Editors and Affiliations

  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Pavlakis, M., Haririan, A., Klassen, D.K. (2006). BK Virus Infection after Non-Renal Transplantation. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_13

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