This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD, 2000, Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8. Eur J Biochem. 267: 6140–6150.
Ariga N, Sato E, Ohuchi N, Nagura H, Ohtani H, 2001, Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast. Int J Cancer. 95: 67–72.
Bogenrieder T, Finstad CL, Freeman RH, Papandreou CN, Scher HI, Albino AP, Reuter VE, Nanus DM, 1997, Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue. Prostate. 33: 225–232.
Burger M, Glodek A, Hartmann T, Schmitt-Graff A, Silberstein LE, Fujii N, Kipps TJ, Burger JA, 2003, Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene. 22: 8093–8101.
Busek P, Malik R, Sedo A, 2004, Dipeptidyl peptidase IV activity and/or structure homologues (DASH) and their substrates in cancer. Int J Biochem Cell Biol. 36: 408–421.
Cheng JD, Valianou M, Canutescu AA, Jaffe EK, Lee HO, Wang H, Lai JH, Bachovchin WW, Weiner LM, 2005, Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. Mol Cancer Ther. 4: 351–60.
De Meester I, Durinx C, Bal G, Proost P, Struyf S, Goossens F, Augustyns K, Scharpe S, 2000, Natural substrates of dipeptidyl peptidase IV. Adv Exp Med Biol. 477: 67–87.
Duke-Cohan JS, Kim JH, Azouz A, 2004, Attractin: cautionary tales for therapeutic intervention in molecules with pleiotropic functionality. J. Environ Pathol Toxicol Oncol. 23: 1–11.
Goodman JD, Rozypal TL, Kelly T, 2003, Seprase, a membrane-bound protease, alleviates the serum growth requirement of human breast cancer cells. Clin Exp Metastasis 20: 459–470.
Hall JM, Korach KS, 2003, Stromal cell-derived factor 1, a novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol Endocrinol. 17: 792–803.
Huang Y, Wang S, Kelly T, 2004, Seprase promotes rapid tumor growth and increased microvessel density in a mouse model of human breast cancer. Cancer Res. 64: 2712–6.
Hwang JH, Hwang JH, Chung HK, Kim DW, Hwang ES, Suh JM, Kim H, You KH, Kwon OY, Ro HK, Jo DY, Shong M, 2003, CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. J Clin Endocrinol Metab. 88: 408–416.
Iwabuchi H, Toriya K, Mimura T, Tamai S, Ito K, Kato H, 1996, Staining for dipeptidyl aminopeptidase IV activity in nodular thyroid diseases. Acta Cytol. 40: 158–163.
Iwasa S, Jin X, Okada K, Mitsumata M, Ooi A, 2003, Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer. Cancer Lett. 199: 91–98.
Jensen JA, Carroll RE, Benya RV, 2001, The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer. Peptides. 22: 689–699.
Jin X, Iwasa S, Okada K, Mitsumata M, Ooi A, 2003, Expression patterns of seprase, a membrane serine protease, in cervical carcinoma and cervical intraepithelial neoplasm. Anticancer Res. 23: 3195–3198.
Kajiyama H, Kikkawa F, Suzuki T, Shibata K, Ino K, Mizutani S, 2002, Prolonged survival and decreased invasive activity attributable to dipeptidyl peptidase IV overexpression in ovarian carcinoma. Cancer Res. 62: 2753–2757.
Kajiyama H, Kikkawa F, Khin E, Shibata K, Ino K, Mizutani S, 2003, Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Cancer Res. 63: 2278–2283.
Kelly T, Kechelava S, Rozypal TL, West KW, Korourian S, 1998, Seprase, a membrane-bound protease, is overexpressed by invasive ductal carcinoma cells of human breast cancers. Mod Pathol. 11: 855–63.
Khin EE, Kikkawa F, Ino K, Kajiyama H, Suzuki T, Shibata K, Tamakoshi K, Nagasaka T, Mizutani S, 2003, Dipeptidyl peptidase IV expression in endometrial endometrioid adenocarcinoma and its inverse correlation with tumor grade. Am J Obstet Gynecol. 188: 670–676.
Kijima T, Maulik G, Ma PC, Tibaldi EV, Turner RE, Rollins B, Sattler M, Johnson BE, Salgia R, 2002, Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res. 62: 6304–6311.
Komatsu M, Urade M, Yamaoka M, Fukasawa K, Harada M, 1987, Alteration in dipeptidyl peptidase activities in cultured human carcinoma cells. J Natl Cancer Inst. 78: 863–868.
Lambeir AM, Durinx C, Scharpe S, De Meester I, 2003, Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci. 40: 209–94.
Lee BC, Lee TH, Avraham S, Avraham HK, 2004, Involvement of the chemokine receptor CXCR4 and its ligand stromal cell-derived factor 1alpha in breast cancer cell migration through human brain microvascular endothelial cells. Mol Cancer Res. 2: 327–338.
Luboshits G, Shina S, Kaplan O, Engelberg S, Nass D, Lifshitz-Mercer B, Chaitchik S, Keydar I, Ben Baruch A, 1999, Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinoma. Cancer Res. 59: 4681–4687.
Mizokami Y, Kajiyama H, Shibata K, Ino K, Kikkawa F, Mizutani S, 2004, Stromal cell-derived factor-1alpha-induced cell proliferation and its possible regulation by CD26/dipeptidyl peptidase IV in endometrial adenocarcinoma. Int J Cancer 110: 652–659.
Mochizuki H, Matsubara A, Teishima J, Mutaguchi K, Yasumoto H, Dahiya R, Usui T, Kamiya K, 2004, Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis. Biochem Biophys Res Commun. 320: 656–663.
Monsky WL, Lin CY, Aoyama A, Kelly T, Akiyama SK, Mueller SC, Chen WT, 1994, A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells. Cancer Res. 54: 5702–5710.
Mori Y, Kono K, Matsumoto Y, Fujii H, Yamane T, Mitsumata M, Chen WT, 2004, The expression of a type II transmembrane serine protease (Seprase) in human gastric carcinoma. Oncology. 67: 411–419.
Mrowietz U, Schwenk U, Maune S, Bartels J, Kupper M, Fichtner I, Schroder JM, Schadendorf D, 1999, The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice. Br J Cancer. 79: 1025–1031.
Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E, Zlotnik A, 2001, Involvement of chemokine receptors in breast cancer metastasis. Nature. 410: 50–56.
Murakami T, Maki W, Cardones AR, Fang H, Tun KA, Nestle FO, Hwang ST, 2002, Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res. 62: 7328–7334.
Nagakawa O, Ogasawara M, Murata J, Fuse H, Saiki I, 2001, Effect of prostatic neuropeptides on migration of prostate cancer cell lines. Int J Urol. 8: 65–70.
Okada K, Chen WT, Iwasa S, Jin X, Yamane T, Ooi A, Mitsumata M, 2003, Seprase, a membrane-type serine protease, has different expression patterns in intestinal-and diffuse-type gastric cancer. Oncology. 65: 363–370.
Palma C, Maggi CA, 2000, The role of tachykinins via NK1 receptors in progression of human gliomas. Life Sci. 67: 985–1001.
Qi SY, Riviere PJ, Trojnar J, Junien JL, Akinsanya KO, 2003, Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Biochem J. 373: 179–189.
Ramirez-Montagut T, Blachere NE, Sviderskaya EV, Bennett DC, Rettig WJ, Garin-Chesa P, Houghton AN, 2004, FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor. Oncogene. 23: 5435–5446.
Reubi JC, Gugger M, Waser B, Schaer JC, 2001, Y(1)-mediated effect of neuropeptide Y in cancer: breast carcinomas as targets. Cancer Res. 61: 4636–4641.
Reubi JC, 2003, Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr Rev. 24: 389–427.
Scotton CJ, Wilson JL, Scott K, Stamp G, Wilbanks GD, Fricker S, Bridger G, Balkwill FR, 2002, Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res. 62: 5930–5938.
Sedo A, Krepela E, Kasafirek E, 1989, A kinetic fluorometric assay of dipeptidyl peptidase IV in viable human blood mononuclear cells. Biochimie. 71: 757–761.
Sedo A, Krepela E, Kasafirek E, Kraml J, Kadlecova L, 1991, Dipeptidyl peptidase IV in the human lung and spinocellular lung cancer. Physiol Res. 40: 359–362.
Sedo A, Malik R, 2001, Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim Biophys Acta. 1550: 107–116.
Tseng WW, Liu CD, 2002, Peptide YY and cancer: current findings and potential clinical applications. Peptides. 23: 389–395.
Vanhoof G, Goossens F, De Meester I, Hendriks D, Scharpe S, 1995, Proline motifs in peptides and their biological processing. FASEB J. 9: 736–744.
Wesley UV, Albino AP, Tiwari S, Houghton AN, 1999, A role for dipeptidyl peptidase IV in suppressing the malignant phenotype of melanocytic cells. J Exp Med. 190: 311–322.
Wesley UV, Tiwari S, Houghton AN, 2004, Role for dipeptidyl peptidase IV in tumor suppression of human non small cell lung carcinoma cells. Int J Cancer. 109: 855–866.
Wesley UV, McGroarty M, Homoyouni A, 2005, Dipeptidyl peptidase inhibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway. Cancer Res. 65: 1325–1334.
Wilson MJ, Ruhland AR, Quast BJ, Reddy PK, Ewing SL, Sinha AA, 2000, Dipeptidyl peptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands. J Androl. 21: 220–226.
Zeelenberg IS, Ruuls-Van Stalle L, Roos E, 2003, The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res. 63: 3833–3839.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Busek, P., Krepela, E., Mares, V., Vlasicova, K., Sevcik, J., Sedo, A. (2006). Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer. In: Lendeckel, U., Reinhold, D., Bank, U. (eds) Dipeptidyl Aminopeptidases. Advances in Experimental Medicine and Biology, vol 575. Springer, Boston, MA . https://doi.org/10.1007/0-387-32824-6_6
Download citation
DOI: https://doi.org/10.1007/0-387-32824-6_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-29058-4
Online ISBN: 978-0-387-32824-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)