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Dipeptidyl Aminopeptidases pp 119–133Cite as

Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)

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Part of the book series: Advances in Experimental Medicine and Biology ((volume 575))

5. Conclusions

Incretin based therapies for type 2 diabetes mellitus are quite promising. Presently, basic research places both GIP and GLP-1 based approaches on an equal standing. Recently, there has been renewed interest into the physiology of GIP in humans, and thus it is possible that DP IV resistant GIP analogues will be administered to human diabetics, perhaps reconciling differences between clinical and pre-clinical studies. Development of injection-delivered GLP-1 derivatives continues to meet expectations as a therapeutic option for the future. Particular attention to severity of diabetes and age must be considered when examining the effectiveness of either GIP or GLP-1 based analogues in human patients. Despite some uncertainties as to the precise mediators of DP IV inhibitors, data from mouse models indicate that the beneficial effects are conveyed by the known incretin hormones. Predictions of the relative contributions of GIP and GLP-1 to the glucose lowering activity of DP IV inhibition have been made, however, experimental data is required for conclusive resolution of this point. Only specifically designed studies can answer this question using selective antagonists of either the GIP or GLP-1 receptor, alone or in combination, in conjunction with DP IV inhibitors in healthy and diabetic humans.

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Authors and Affiliations

  1. Department of Metabolism and Endocrinology, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, Brussels, Belgium

    Simon A. Hinke

  2. Department of Cellular and Physiological Sciences, University of British Columbia, 2146 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada

    Raymond A. Pederson & Christopher H. S. McIntosh

Authors
  1. Simon A. Hinke
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  2. Raymond A. Pederson
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  3. Christopher H. S. McIntosh
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Editor information

Editors and Affiliations

  1. Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel , Dirk Reinhold  & Ute Bank ,  & 

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© 2006 Springer Science+Business Media, Inc.

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Hinke, S.A., Pederson, R.A., McIntosh, C.H.S. (2006). Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM). In: Lendeckel, U., Reinhold, D., Bank, U. (eds) Dipeptidyl Aminopeptidases. Advances in Experimental Medicine and Biology, vol 575. Springer, Boston, MA . https://doi.org/10.1007/0-387-32824-6_13

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