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Protein Movement Across Membranes pp 19–32Cite as

Preprotein Translocation through the Sec Translocon in Bacteria

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Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The Sec translocase or translocon is the essential and ubiquitous system for protein translocation across or into the membrane. The core channel, the SecYE complex, is conserved across biological kingdoms and most of the polypeptide chains which are routed to extracellular or membrane locations in Bacteria use this pathway. Biochemical and genetic approaches have yielded a substantial body of information about functional aspects of Sec-mediated translocation and this information has recently been enriched with structural data at atomic resolution. This chapter reviews previously acquired facts and concepts concerning the Sec translocase of Bacteria in light of recent structural results and considers implications of these findings.

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  1. Department of Biochemistry and Molecular Biology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B.C., V6T 1Z3, Canada

    Antoine P. Maillard, Kenneth K. Y. Chan & Franck Duong

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  1. Antoine P. Maillard
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  2. Kenneth K. Y. Chan
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  3. Franck Duong
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Maillard, A.P., Chan, K.K.Y., Duong, F. (2005). Preprotein Translocation through the Sec Translocon in Bacteria. In: Protein Movement Across Membranes. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-30871-7_2

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