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6. References
Barroso, N., and Rodriguez, M., 1996, Action of beta-phenylethylamine and related amines on nigrostriatal dopamine neurotransmission. Eur. J. Pharmacol. 297:195–203.
Berry, M.D., 2004, Mammalian central nervous system trace amines. Pharmacologic amphetamines, physiologic neuromodulators. J. Neurochem. 90:257–271.
Bonci, A., and Williams, J.T., 1996, A common mechanism mediates long-term changes in synaptic transmission after chronic cocaine and morphine. Neuron. 16:631–639.
Borowsky, B., Adham, N., Jones, K.A., Raddatz, R., Artymyshyn, R., Ogozalek, K.L., Durkin, M.M., Lakhlani, P.P., Bonini, J.A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F. Y., Branchek, T.A., and Gerald, C., 2001, Trace amines: identification of a family of mammalian G proteincoupled receptors. Proc. Natl. Acad. Sci. U S A 98:8966–8971.
Boulton, A.A., 1976, Identification, distribution, metabolism, and function of meta and para tyramine, phenylethylamine and tryptamine in brain. Adv. Biochem. Psychopharmacol. 15:57–67.
Boulton, A.A., 1982, Some aspects of basic psychopharmacology: the trace amines. Prog. Neuropsychopharmacol Biol. Psychiatry 6:563–570.
Branchek, T.A., and Blackburn, T.P., 2003, Trace amine receptors as targets for novel therapeutics: legend, myth and fact. Curr. Opin. Pharmacol. 3:90–97.
Bunzow, J.R., Sonders, M.S., Arttamangkul, S., Harrison, L.M., Zhang, G., Quigley, D.I., Darland, T., Suchland, K.L., Pasumamula, S., Kennedy, J.L., Olson, S.B., Magenis, R.E., Amara, S. G., and Grandy, D.K., 2001, Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 60:1181–1188.
Cameron, D.L., and Williams, J.T., 1993, Dopamine D1 receptors facilitate transmitter release. Nature 366:344–347.
Couve, A., Thomas, P., Calver, A.R., Hirst, W.D., Pangalos, M.N., Walsh, F.S., Smart, T.G., and Moss, S.J., 2002, Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling. Nat. Neurosci. 5:415–424.
Durden, D.A., and Philips, S.R., 1980, Kinetic measurements of the turnover rates of phenylethylamine and tryptamine in vivo in the rat brain. J. Neurochem. 34:1725–1732.
Federici, M., Geracitano, R., Tozzi, A., Longone, P., Di Angelantonio, S., Bengtson, C.P., Bernardi, G., and Mercuri, N.B., 2005, Trace amines depress GABAB response in dopaminergic neurons by inhibiting G-βγ-gated inwardly rectifying potassium channels. Mol. Pharmacol. 67:1283–1290.
Geracitano, R., Federici, M., Prisco, S., Bernardi, G., and Mercuri, N.B., 2004, Inhibitory effects of trace amines on rat midbrain dopaminergic neurons. Neuropharmacology 46:807–814.
Hoang, Q.V., Bajic, D., Yanagisawa, M., Nakajima, S., and Nakajima, Y., 2003, Effects of orexin, hypocretin on GIRK channels. J. Neurophysiol. 90:693–702.
Huang, C.L., Jan, Y.N., and Jan, L.Y., 1997, Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett. 405:291–298.
Janssen, P.A., Leysen, J.E., Megens, A.A., and Awouters, F.H., 1999, Does phenylethylamine act as an endogenous amphetamine in some patients? Int. J. Neuropsychopharmcol 2:229–240.
Johnson, S.W., and North, R.A., 1992, Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J. Physiol. 450:455–468.
Juorio, A.V., 1976, Presence and metabolism of beta-phenylethylamine, p-tyramine, m-tyramine and tryptamine in the brain of the domestic fowl. Brain Res. 111:442–445.
Juorio, A.V., Paterson, I.A., Zhu, M.Y., and Matte, G., 1991, Electrical stimulation of the substantia nigra and changes of 2-phenylethylamine synthesis in the rat striatum. J. Neurochem. 56:213–220.
Kim, K.A., and von Zastrow, M., 2001, Old drugs learn new tricks: insights from mammalian trace amine receptors. Mol. Pharmacol. 60:1165–1167.
Kosa, E., Marcilhac-Flouriot, A., Fache, M.P., and Siaud, P., 2000, Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat. Pharmacol. Biochem. Behav. 67:527–535.
Kunkel, M.T., and Peralta, E.G., 1995, Identification of domains conferring G protein regulation on inward rectifier potassium channels. Cell 83:443–449.
Lacey, M.G., Mercuri, N.B., and North, R.A., 1988, On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. J. Physiol. 401:437–453.
Lewohl, J.M., Wilson, W.R., Mayfield, R.D., Brozowski, S.J., Morrisett, R.A., and Harris, R.A., 1999, Gproteincoupled inwardly rectifying potassium channels are targets of alcohol action. Nat. Neurosci. 2:1084–1090.
Mercuri, N.B., Bonci, A., Calabresi, P., Stefani, A., and Bernardi, G., 1995, Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons. Eur. J. Neurosci. 7:462–469.
Meyer, T., Wellner-Kienitz, M.C., Biewald, A., Bender, K., Eickel, A., and Pott, L., 2001, Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes. J. Biol. Chem. 276:5650–5658.
Mundorf, M.L., Hochstetler, S.E., and Wightman, R.M., 1999, Amine weak bases disrupt vesicular storage and promote exocytosis in chromaffin cells. J. Neurochem. 73:2397–2405.
Nguyen, T.V., and Juorio, A.V., 1989, Binding sites for brain trace amines. Cell Mol. Neurobiol. 9:297–311.
Parker, E.M., and Cubeddu, L.X., 1988, Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding. J. Pharmacol. Exp. Ther. 245:199–210.
Paterson, I.A., Juorio, A.V., and Boulton, A.A., 1990, 2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system? J. Neurochem. 55:1827–1837.
Petit-Jacques, J., Sui, J.L., and Logothetis, D.E., 1999, Synergistic activation of G protein-gated inwardly rectifying potassium channels by the betagamma subunits of G proteins and Na(+) and Mg(2+) ions. J. Gen. Physiol. 114:673–684.
Premont, R.T., Gainetdinov, R.R., and Caron, M.G., 2001, Following the trace of elusive amines. Proc. Natl. Acad. Sci. U S A 98:9474–9475.
Scarponi, M., Bernardi, G., and Mercuri, N.B., 1999, Electrophysiological evidence for a reciprocal interaction between amphetamine and cocaine-related drugs on rat midbrain dopaminergic neurons. Eur. J. Neurosci. 11:593–598.
Schonfeld, C.L., and Trendelenburg, U., 1989, The release of 3H-noradrenaline by p-and m-tyramines and — octopamines, and the effect of deuterium substitution in alpha-position. Naunyn. Schmiedebergs Arch. Pharmacol. 339:433–440.
Skerritt, J.H., Guihot, S.L., McDonald, S.E., and Culvenor, R.A., 2000, Development of immunoassays for tyramine and tryptamine toxins of Phalaris aquatica L. J. Agric. Food Chem. 48:27–32.
Sui, J.L., Petit-Jacques, J., and Logothetis, D.E., 1998, Activation of the atrial KACh channel by the betagamma subunits of G proteins or intracellular Na+ ions depends on the presence of phosphatidylinositol phosphates. Proc. Natl. Acad. Sci. U S A 95:1307–1312.
Tozzi, A., Guatteo, E., Caputi, L., Bernardi, G., and Mercuri, N.B., 2001, Group I mGluRs coupled to G proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain. J. Neurophysiol. 85:2490–2497.
Uchida, S., Akaike, N., and Nabekura, J., 2000, Dopamine activates inward rectifier K+ channel in acutely dissociated rat substantia nigra neurones. Neuropharmacology 39:191–201.
Ungar, F., Mosnaim, A.D., Ungar, B., and Wolf, M.E., 1977, Tyramine-binding by synaptosomes from rat brain: effect of centrally active drugs. Biol. Psychiatry 12:661–668.
Vaccari, A., 1986, High affinity binding of [3H]-tyramine in the central nervous system. Br J Pharmacol. 89:15–25.
Vaccari, A., and Gessa, G., 1989, [3H]tyramine binding: a comparison with neuronal [3H]dopamine uptake and [3H]mazindol binding processes. Neurochem. Res. 14:949–955.
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Geracitano, R., Federici, M., Tozzi, A., Longone, P., Bernardi, G., Mercuri, N.B. (2005). Trace Amines Cause More than One Effect on Dopaminergic Neurons. In: Bolam, J.P., Ingham, C.A., Magill, P.J. (eds) The Basal Ganglia VIII. Advances in Behavioral Biology, vol 56. Springer, Boston, MA. https://doi.org/10.1007/0-387-28066-9_15
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