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Disorders of the Vitreous and Vitreoretinal Interface

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Abstract

The human vitreous is a complex extracellular matrix composed of 98% water and 2% solid material. The basic structure of the vitreous matrix is a scaffold of cross-linked collagen fibrils with hyaluronic acid molecules within the scaffold. Hyaluronic acid is very hydrophilic, and water molecules are attracted to the scaffold providing turgor and rigidity to the matrix. The vitreous is primarily a solid gel in children’s eyes but becomes progressively more liquid with aging. Liquefaction of the vitreous occurs when the hyaluronic acid depolymerizes, freeing the bound water and allowing the collagen scaffold to collapse. The collagen filaments then coalesce to form collagen fibers, causing the “floaters“ seen by patients with aging of the vitreous.

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Authors
  1. David M. Brown
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  2. Thomas A. Weingeist
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Editor information

Editors and Affiliations

  1. Wright Foundation for Pediatric Ophthalmology, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  2. Pediatric Ophthalmology, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  3. University of Southern California—Keck School of Medicine, Los Angeles, CA, USA

    Kenneth W. Wright MD (Director and Clinical Professor of Ophthalmology) (Director and Clinical Professor of Ophthalmology)

  4. Focus On You, Inc., Palm Desert, CA, USA

    Peter H. Spiegel MD

  5. Inland Eye Clinic, Murrieta, CA, USA

    Peter H. Spiegel MD

  6. Children’s Eye Institute, Upland, CA, USA

    Peter H. Spiegel MD

  7. Stroger Hospital of Cook County, Chicago, IL, USA

    Lisa S. Thompson MD (Attending Physician) (Attending Physician)

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© 2006 Springer Science+Business Media, Inc.

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Brown, D.M., Weingeist, T.A. (2006). Disorders of the Vitreous and Vitreoretinal Interface. In: Wright, K.W., Spiegel, P.H., Thompson, L.S. (eds) Handbook of Pediatric Retinal Disease. Springer, New York, NY. https://doi.org/10.1007/0-387-27933-4_6

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  • DOI: https://doi.org/10.1007/0-387-27933-4_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-27932-9

  • Online ISBN: 978-0-387-27933-6

  • eBook Packages: MedicineMedicine (R0)

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