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The Local Cardiac Renin Angiotensin-Aldosterone System pp 7–15Cite as

Cardiac (Pro)Renin Receptors: Functional Properties and Potential Significance

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Part of the book series: Basic Science for the Cardiologist ((volume 20))

Abstract

In many tissues, local angiotensin generation depends on uptake of circulating renin and/or prorenin. Such uptake involves both diffusion into the interstitial space and binding to (pro)renin receptors. This review describes the current status of cardiac (pro)renin receptors, and focusses on their potential significance. (Pro)renin receptors bind both renin and prorenin, and prorenin undergoes a conformational change (‘non-proteolytic’ activation) following binding, thereby allowing cell surface angiotensin generation with both renin and prorenin. Renin and prorenin binding also induced direct, angiotensin-independent effects (e.g., ERK1/2 activation), suggesting that renin and prorenin may act as agonists. Finally, under certain conditions binding resulted in internalization of renin and prorenin. Internalized renin and prorenin were either degraded or, in the case of unglycosylated prorenin, contributed to intracellular angiotensin generation. Taken together, (pro)renin receptors could provide an important new drug target, allowing selective interference with angiotensin production at tissues sites and/or direct (pro)renin-induced effects.

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Authors and Affiliations

  1. Inserm U36, Collège de France, Paris, France

    Geneviève Nguyen

  2. Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands

    A. H. Jan Danser

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  1. Geneviève Nguyen
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Editors and Affiliations

  1. Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA, 70121, USA

    Edward D. Frohlich M.D.  & Richard N. Re M.D.  & 

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Nguyen, G., Jan Danser, A.H. (2006). Cardiac (Pro)Renin Receptors: Functional Properties and Potential Significance. In: Frohlich, E.D., Re, R.N. (eds) The Local Cardiac Renin Angiotensin-Aldosterone System. Basic Science for the Cardiologist, vol 20. Springer, Boston, MA. https://doi.org/10.1007/0-387-27826-5_2

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  • DOI: https://doi.org/10.1007/0-387-27826-5_2

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-0-387-27826-1

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