Abstract
In the fruit fly Drosophila melanogaster, the Toll receptor plays two major roles, one is in early development and the other concerns resistance to infection. In mammals, the multiple Toll-Like Receptors (TLRs) are known to be key mediators of innate immunity. Caenorhabditis elegans possesses only one TLR (TOL-1) which is required during development, in a TIR-domain independent fashion. It also functions indirecdy in defence, via a behavioral mechanism that keeps worms away from the pathogenic bacterium Serratia marcescens. We describe here that the tol-1-dependent avoidance behavior involves the recognition of a signal that includes contributions from both the bacteria and the worms, themselves. We outline the current understanding of how C. elegans detects bacteria and other worms and speculate on a possible link between chemosensation and immune recognition.
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Pujol, N., Ewbank, J.J. (2005). Pathogen Avoidance Using Toll Signaling in C. elegans . In: Toll and Toll-Like Receptors: An Immunologic Perspective. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-27445-6_8
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DOI: https://doi.org/10.1007/0-387-27445-6_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-48237-3
Online ISBN: 978-0-387-27445-4
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