Abstract
Inhibition is mediated by two main types of GABA receptors — ionotropic GABAA receptors that directly open Cl− channels, and metabotropic GABAB receptors that act through G-protein coupled second messenger systems.1, 2, 3 Postsynaptic GABAB receptors are found mainly on the dendrites of pyramidal cells (Fig. 1) and interneurons in the hippocampus, and they induce a slow K+-mediated inhibitory postsynaptic current (IPSC).2 Presynaptic GABAB receptors at the axon terminals (Fig. 1) mediate presynaptic inhibition of GABAergic terminals (autoreceptors) or glutamatergic terminals (heteroreceptors), likely by decreasing Ca2+ influx.2, 4
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
7. References
A. Couve, S. J. Moss, and M.N. Pangalos, GABAB receptors: a new paradigm in G protein signaling, Mol Cell Neurosci. 16, 296–312 (2000).
U. Misgeld, M. Bijak, and W. Jarolimek, A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system, Prog. Neurobiol. 46, 423–462 (1995).
I. Mody, Y. De Koninck, T. S. Otis, and I. Soltesz, Bridging the cleft at GABA synapses in the brain, Trends Neurosci. 17, 517–525 (1994).
N. G. Bowery, B. Bettler, W. Froestl, J. P. Gallagher, F. Marshall, M. Raiteri, T. I. Bonner, and S. J. Enna, International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function, Pharmacol.Rev. 54, 247–264 (2002).
H. M. Prosser, C. H. Gill, W. D. Hirst, E. Grau, M. Robbins, A. Calver, E. M. Soffin, C. E. Farmer, C. Lanneau, J. Gray, E. Schenck, B. S. Warmerdam, C. Clapham, C. Reavill, D. C. Rogers, T. Stean, N. Upton, K. Humphreys, A. Randall, M. Geppert, C. H. Davies, and M. N. Pangalos, Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice, Mol. Cell Neurosci. 17, 1059–1070 (2001).
V. Schuler, C. Luscher, C. Blanchet, N. Klix, G. Sansig, K. Klebs, M. Schmutz, J. Heid, C. Gentry, L. Urban, A. Fox, W. Spooren, A. L. Jaton, J. Vigouret, M. Pozza, P. H. Kelly, J. Mosbacher, W. Froestl, E. Kaslin, R. Korn, S. Bischoff, K. Kaupmann, P. H. van der, and B. Bettler, Epilepsy, hyperalgesia, impaired memory, and loss of pre-and postsynaptic GABA(B) responses in mice lacking GABA(B(1), Neuron 31, 47–58 (2001).
M. Vergnes, A. Boehrer, S. Simler, R. Bernasconi, and C. Marescaux, Opposite effects of GABAB receptor antagonists on absences and convulsive seizures, Eur. J. Pharmacol. 332, 245–255 (1997).
A. Dennison, G. C. Teskey, and D. P. Cain, Persistence of kindling: effect of partial kindling, retention interval, kindling site, and stimulation parameters, Epilepsy Res. 21, 171–182 (1995).
L. S. Leung, C. Wu, K. Wu, B. Shen, R. Sutherland, and D. Zhao, Long-lasting behavioral and electrophysiological effects induced by partial hippocampal kindling, in: Kindling 5, edited by M. E. Corcoran, and S. Moshe (Plenum Press, New York, 1998), pp. 395–408.
C. H. Davies, S. N. Davies, and G. L. Collingridge, Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus, J. Physiol. (Lond.) 424, 513–531 (1990).
C. Wu and L. S. Leung, Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1, J. Neurosci. 17, 9261–9269 (1997).
E. H. Buhl, T. S. Otis, and I. Mody, Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model, Science 271, 369–373 (1996).
R. Siushansian, N. Poon, C. Naus, J. F. Bechberger, J. Mao, and L. S. Leung, Up-regulation of mRNA expression of GABAB receptor 1B in the rat following hippocampal kindling, Neurosci. Abstr. 27, #558.6. (2001).
W. Kamphuis, J. A. Goiter, and F. H. Lopes da Silva, A long-lasting decrease in the inhibitory effect of GABA on glutamate responses of hippocampal pyramidal neurons induced by kindling epileptogenesis, Neuroscience 41, 425–431 (1991).
J. S. Isaacson, J. M. Solis, and R. A. Nicoll, Local and diffuse synaptic actions of GABA in the hippocampus, Neuron 10, 165–175 (1993).
E. K. Asprodini, D. G. Rainnie, and P. Shinnick-Gallagher, Epileptogenesis reduces the sensitivity of presynaptic gamma-aminobutyric acid B receptors on glutamatergic afferents in the amygdala, J. Pharmacol. Exp. Ther. 262, 1011–1021 (1992).
X. H. Liu and L. S. Leung, Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells, Epilepsy Res. 57, 33–47 (2003).
O. Honmou, J. D. Kocsis, and G. B. Richerson, Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro, Epilepsy Res. 20, 193–202 (1995).
J. M. Solis and R. A. Nicoll, Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus, Neurosci. Lett. 147, 16–20 (1992).
W. Kamphuis, E. Huisman, M. J. Veerman, and F. H. Lopes da Silva, Development of changes in endogenous GABA release during kindling epileptogenesis in rat hippocampus, Brain Res. 545, 33–40 (1991).
M. Zuiderwijk, G. C. Faas, F. H. Lopes da Silva, and W. E. J. M. Ghijsen, Electrically stimulated GABA release in rat hippocampus CA1 region is enhanced in kindling epileptogenesis, Neurosci. Abstr. 23, 2161 (1997).
J. Francis, B. P. Jung, G. Zhang, W. Ho, J. Cheng, W. M. Burnham, and J. H. Eubanks, Perforant pathway kindling transiently induces the mRNA expression of GABA-B receptor subtypes R1A and R2 in the adult rat hippocampus, Brain Res Mol. Brain Res. 91, 159–162 (2001).
Z. Kokaia and M. Kokaia, Changes in GABA(B) receptor immunoreactivity after recurrent seizures in rats. Neurosci. Lett. 315, 85–88 (2001).
A. Billinton, V. H. Baird, M. Thorn, J. S. Duncan, N. Upton, and N. G. Bowery, GABA(B(1)) mRNA expression in hippocampal sclerosis associated with human temporal lobe epilepsy, Brain Res. Mol. Brain Res. 86, 84–89 (2001).
A. P. Princivalle, J. S. Duncan, M. Thorn, and N. G. Bowery, Studies of GABA(B) receptors labelled with [(3)H]-CGP62349 in hippocampus resected from patients with temporal lobe epilepsy, Br. J. Pharmacol. 136, 1099–1106 (2002).
C. H. Davies, S. J. Starkey, M. F. Pozza, and G. L. Collingridge, GABAB autoreceptors regulate the induction of LTP, Nature 349, 609–611 (1991).
D. D. Mott and D. V. Lewis, Facilitation of the induction of long-term potentiation by GABAB receptors, Science 252, 1718–1720 (1991).
L. S. Leung and C. Wu, Kindling suppresses primed-burst induced long-term potentiation in hippocampal CA1, NeuroReport 14, 211–214 (2003).
R. U. Muller, M. Stead, and J. Pach, The hippocampus as a cognitive graph, J. Gen. Physiol. 107, 663–694 (1996).
L. S. Leung, D. Zhao, and B. Shen, Long-lasting effects of partial hippocampal kindling on hippocampal physiology and function, Hippocampus 4, 696–704 (1994).
L. S. Leung, Hippocampal electrical activity following local tetanization. I. Afterdischarges, Brain Res. 419, 173–187 (1987).
M. Lerner-Natoli, G. Rondouin, and M. Baldy-Moulinier, Evolution of wet dog shakes during kindling in rats: comparison between hippocampal and amygdala kindling, Exp. Neurol. 83, 1–12 (1984).
D. P. Frush and J. O. McNamara, Evidence implicating dentate granule cells in wet dog shakes produced by kindling stimulations of entorhinal cortex, Exp. Neurol., 92, 102–113 (1986).
B. P. Damiano and J. D Connor, Hippocampal mediation of shaking behavior induced by electrical stimulation of the perforant path in the rat, Brain Res. 308, 383–386 (1984).
J. Ma and L. S. Leung, Schizophrenia-like behavioral changes after partial hippocampal kindling, Brain Res. 997, 111–118 (2004).
M Koch and U. Ebert, Deficient sensorimotor gating following seizures in amygdala-kindled rats, Biol. Psychiatry 44, 290–297 (1998).
D. Braff, C. Stone, E. Callaway, M. Geyer, I. Glick, and L. Bali, Prestimulus effects on human startle reflex in normals and schizophrenics, Psychophysiology 15, 339–343 (1978).
K. M. Hershman, R. Freedman, and P. C. Bickford, GABAB antagonists diminish the inhibitory gating of auditory response in the rat hippocampus, Neurosci. Lett. 190(2), 133–6 (1995).
K. J. Canning and L. S. Leung, Excitability of rat dentate gyrus granule cells in vivo is controlled by tonic and evoked GABAB receptor-mediated inhibition, Brain Res. 86, 271–275 (2000).
F. H. Brucato, R. A. Morrisett, W. A. Wilson, and H. S. Swartzwelder, The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo, Brain Res. 588, 150–153 (1992).
K. Wu and L. S. Leung, Enhancement of multisynaptic transmission through the hippocampo-entorhino-hippocampal loop in partially kindled rats in vivo, Neurosci. Abstr. 25, 1351 (1999).
M. Sato, R. J. Racine, and D. C. McIntyre, Kindling: basic mechanisms and clinical validity, Electroencephalogr.Clin.Neurophysiol. 76, 459–472 (1990).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science+Business Media, Inc.
About this paper
Cite this paper
Leung, L.S., Liu, X., Canning, K.J., Shen, B. (2005). Hippocampal Kindling and GABAB Receptor Functions. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_9
Download citation
DOI: https://doi.org/10.1007/0-387-26144-3_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-24380-1
Online ISBN: 978-0-387-26144-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)