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Development of Kindling in Immature Fast and Slow Kindling Rats

  • Conference paper
Kindling 6

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 55))

Abstract

Several epileptic syndromes have a genetic background. Thus, genetic models of epilepsy in rodents provide a useful tool to study basic mechanisms of seizures.1 Using selective breeding technique, two new strains of rats with differential rates of amygdala kindling were produced and named “FAST” and “SLOW” kindling rats.2, 3 Although the FAST and SLOW kindling rats have differences in kindling paradigms in several brain regions such as hippocampus, piriform and perirhinal cortices, the most striking differences were found during amygdala kindling. Besides the faster kindling rate, amygdala stimulation in FAST rats resulted in significantly longer afterdischarges (ADs) both prior to and after the kindling compared to the SLOW rats.2, 3 The differences in the excitability of these two strains were determined in adult rats.

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Author information

Authors and Affiliations

  1. Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Jana Velíšková

  2. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, 10461

    Jeremy Asnis & Fred A. Lado

  3. Department of Psychology, Institute of Neuroscience, Carleton University, Ottawa, Ontario, K1S 5B6, Canada

    Dan C. McIntyre

Authors
  1. Jana Velíšková
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  2. Jeremy Asnis
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  3. Fred A. Lado
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  4. Dan C. McIntyre
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Editor information

Editors and Affiliations

  1. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Michael E. Corcoran

  2. Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA

    Solomon L. Moshé

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© 2005 Springer Science+Business Media, Inc.

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Velíšková, J., Asnis, J., Lado, F.A., McIntyre, D.C. (2005). Development of Kindling in Immature Fast and Slow Kindling Rats. In: Corcoran, M.E., Moshé, S.L. (eds) Kindling 6. Advances in Behavioral Biology, vol 55. Springer, Boston, MA. https://doi.org/10.1007/0-387-26144-3_3

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