Abstract
This chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.
Key words
- Proteolipid protein (PLP, PLP1)
- myelin basic protein (MBP)
- 2′,3′-cyclic nucleotide 3′ phosphodiesterase (CNPase)
- oligodendrocyte specific protein (OSP)
- myelin associated glycoprotein (MAG)
- myelin-oligodendrocyte glycoprotein (MOG)
- ceramide galactosyltransferase (CGT)
- Oligodendrocyte myelin glycoprotein (OMgp)
- Myelin-associated oligodendrocyte basic protein (MOBP)
- Nogo
- Nogo receptor
- ganglioside
- sulfatide
- cerebroside
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References
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Garbern, J. (2005). Neuroantigens in EAE. In: Lavi, E., Constantinescu, C.S. (eds) Experimental Models of Multiple Sclerosis. Springer, Boston, MA. https://doi.org/10.1007/0-387-25518-4_4
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