This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Amzel, L. M., and Poljak, R. J. (1979). Three-dimensional structure of immunoglobulins. Annu Rev Biochem 48, 961–997.
Anton, L. C., Alcolea, J. M., Sanchez-Corral, P., Marques, G., Sanchez, A., and Vivanco, F. (1989). C3 binds covalently to the C gamma 3 domain of IgG immune aggregates during complement activation by the alternative pathway. Biochem J 257, 831–838.
Arlaud, G. J., and Colomb, M. G. (1987). Modelling of C1, the first component of human complement: towards a consensus? Mol Immunol 24, 317.
Arnold, J. N., Radcliffe, C. M., Wormald, M. R., Royle, L., Harvey, D. J., Crispin, M., Dwek, R. A., Sim, R. B., and Rudd, P. M. (2004) In Press J Immunol.
Baenziger, J., and Kornfeld, S. (1974). Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagines linked oligosaccharide units. J Biol Chem 249, 7260–7269.
Baenziger, J., Kornfeld, S., and Kochwa, S. (1974). Structure of the carbohydrate units of IgE immunoglobulin. I. Over-all composition, glycopeptide isolation, and structure of the high mannose oligosaccharide unit. J Biol Chem 249, 1889–1896.
Baenziger, J., Kornfeld, S., and Kochwa, S. (1974). Structure of the carbohydrate units of IgE immunoglobulin. II. Sequence of the sialic acid-containing glycopeptides. J Biol Chem 249, 1897–1903.
Bos, N. A., Bun, J. C., Popma, S. H., Cebra, E. R., Deenen, G. J., van der Cammen, M. J., Kroese, F. G., and Cebra, J. J. (1996). Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria. Infect Immun 64, 616–623.
Butler, M., Quelhas, D., Critchley, A. J., Carchon, H., Hebestreit, H. F., Hibbert, R. G., Vilarinho, L., Teles, E., Matthijs, G., Schollen, E., et al. (2003). Detailed glycan analysis of serum glycoproteins of patients with congenital disorders of glycosylation indicates the specific defective glycan processing step and provides an insight into pathogenesis. Glycobiology 13, 601–622.
Chapman, A., and Kornfeld, R. (1979). Structure of the high mannose oligosaccharides of a human IgM myeloma protein. II. The minor oligosaccharides of high mannose glycopeptide. J Biol Chem 254, 824–828.
Cooper, N. R. (1985). The classical complement pathway: activation and regulation of the first complement component. Adv Immunol 37, 151–216.
Crispin, M. D., Ritchie, G. E., Critchley, A. J., Morgan, B. P., Wilson, I. A., Dwek, R. A., Sim, R. B., and Rudd, P. M. (2004). Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure. FEBS Lett 566, 270–274.
Dahl, M. R., Thiel, S., Matsushita, M., Fujita, T., Willis, A. C., Christensen, T., Vorup-Jensen, T., and Jensenius, J. C. (2001). MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15, 127–135.
Delacroix, D. L., Dive, C., Rambaud, J. C., and Vaerman, J. P. (1982). IgA subclasses in various secretions and in serum. Immunology 47, 383–385.
Dorrington, K. J., and Bennich, H. H. (1978). Structure-function relationships in human immunoglobulin E. Immunol Rev 41, 3–25.
Duncan, A. R., and Winter, G. (1988). The binding site for C1q on IgG. Nature 332, 738–740.
Endo, T., Mestecky, J., Kulhavy, R., and Kobata, A. (1994). Carbohydrate heterogeneity of human myeloma proteins of the IgA1 and IgA2 subclasses. Mol Immunol 31, 1415–1422.
Field, M. C., Amatayakul-Chantler, S., Rademacher, T. W., Rudd, P. M., and Dwek, R. A. (1994). Structural analysis of the N-glycans from human immunoglobulin A1: comparison of normal human serum immunoglobulin A1 with that isolated from patients with rheumatoid arthritis. Biochem J 299 (Pt 1), 261–275.
Gala, F. A., and Morrison, S. L. (2002). The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1. J Biol Chem 277, 29005–29011.
Garred, P., Madsen, H. O., Marquart, H., Hansen, T. M., Sorensen, S. F., Petersen, J., Volck, B., Svejgaard, A., Graudal, N. A., Rudd, P. M., et al. (2000). Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study. J Rheumatol 27, 26–34.
Ghiran, I., Barbashov, S. F., Klickstein, L. B., Tas, S. W., Jensenius, J. C., and Nicholson-Weller, A. (2000). Complement receptor 1/CD35 is a receptor for mannan-binding lectin. J Exp Med 192, 1797–1808.
Hajela, K., Kojima, M., Ambrus, G., Wong, K. H., Moffatt, B. E., Ferluga, J., Hajela, S., Gal, P., and Sim, R. B. (2002). The biological functions of MBL-associated serine proteases (MASPs). Immunobiology 205, 467–475.
Holmskov, U., Malhotra, R., Sim, R. B., and Jensenius, J. C. (1994). Collectins: collagenous C-type lectins of the innate immune defense system. Immunol Today 15, 67–74.
Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T., and Yamashina, I. (1987). Serum lectin with known structure activates complement through the classical pathway. J Biol Chem 262, 7451–7454.
Iobst, S. T., and Drickamer, K. (1994). Binding of sugar ligands to Ca(2+)-dependent animal lectins. II. Generation of high-affinity galactose binding by site-directed mutagenesis. J Biol Chem 269, 15512–15519.
Jefferis, R., Lund, J., Mizutani, H., Nakagawa, H., Kawazoe, Y., Arata, Y., and Takahashi, N. (1990). A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins. Biochem J 268, 529–537.
Johansen, F. E., Braathen, R., and Brandtzaeg, P. (2001). The J chain is essential for polymeric Ig receptormediated epithelial transport of IgA. J Immunol 167, 5185–5192.
Koppel, R., and Solomon, B. (2001). IgM detection via selective recognition by mannose-binding protein. J Biochem Biophys Methods 49, 641–647.
Lamm, M. E. (1997). Interaction of antigens and antibodies at mucosal surfaces. Annu Rev Microbiol 51, 311–340.
Lipscombe, R. J., Sumiya, M., Hill, A. V., Lau, Y. L., Levinsky, R. J., Summerfield, J. A., and Turner, M. W. (1992). High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum Mol Genet 1, 709–715.
Litman, G. W., Anderson, M. K., and Rast, J. P. (1999). Evolution of antigen binding receptors. Annu Rev Immunol 17, 109–147.
Madsen, H. O., Satz, M. L., Hogh, B., Svejgaard, A., and Garred, P. (1998). Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America. J Immunol 161, 3169–3175.
Malhotra, R., Lu, J., Holmskov, U., and Sim, R. B. (1994). Collectins, collectin receptors and the lectin pathway of complement activation. Clin Exp Immunol 97Suppl 2, 4–9.
Malhotra, R., Wormald, M. R., Rudd, P. M., Fischer, P. B., Dwek, R. A., and Sim, R. B. (1995). Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med 1, 237–243.
Matsushita, M., and Fujita, T. (1992). Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J Exp Med 176, 1497–1502.
Mattu, T. S., Pleass, R. J., Willis, A. C., Kilian, M., Wormald, M. R., Lellouch, A. C., Rudd, P. M., Woof, J. M., and Dwek, R. A. (1998). The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions. J Biol Chem 273, 2260–2272.
Mellis, S. J., and Baenziger, J. U. (1983). Structures of the O-glycosidically linked oligosaccharides of human IgD. J Biol Chem 258, 11557–11563.
Mellis, S. J., and Baenziger, J. U. (1983). Structures of the oligosaccharides present at the three asparaginelinked glycosylation sites of human IgD. J Biol Chem 258, 11546–11556.
Mimura, Y., Church, S., Ghirlando, R., Ashton, P. R., Dong, S., Goodall, M., Lund, J., and Jefferis, R. (2000). The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms. Mol Immunol 37, 697–706.
Nevens, J. R., Mallia, A. K., Wendt, M. W., and Smith, P. K. (1992). Affinity chromatographic purification of immunoglobulin M antibodies utilizing immobilized mannan binding protein. J Chromatogr 597, 247–256.
Norderhaug, I. N., Johansen, F. E., Schjerven, H., and Brandtzaeg, P. (1999). Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol 19, 481–508.
Ogden, C. A., deCathelineau, A., Hoffmann, P. R., Bratton, D., Ghebrehiwet, B., Fadok, V. A., and Henson, P. M. (2001). C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194, 781–795.
Parekh, R. B., Dwek, R. A., Sutton, B. J., Fernandes, D. L., Leung, A., Stanworth, D., Rademacher, T. W., Mizuochi, T., Taniguchi, T., Matsuta, K., and et al. (1985). Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316, 452–457.
Rook, G. A., Steele, J., Brealey, R., Whyte, A., Isenberg, D., Sumar, N., Nelson, J. L., Bodman, K. B., Young, A., Roitt, I. M., and et al. (1991). Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy. J Autoimmun 4, 779–794.
Roos, A., Bouwman, L. H., Munoz, J., Zuiverloon, T., Faber-Krol, M. C., Fallaux-van den Houten, F. C., Klar-Mohamad, N., Hack, C. E., Tilanus, M. G., and Daha, M. R. (2003). Functional characterization of the lectin pathway of complement in human serum. Mol Immunol 39, 655–668.
Roos, A., Bouwman, L. H., van Gijlswijk-Janssen, D. J., Faber-Krol, M. C., Stahl, G. L., and Daha, M. R. (2001). Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol 167, 2861–2868.
Royle, L., Roos, A., Harvey, D. J., Wormald, M. R., van Gijlswijk-Janssen, D., Redwan el, R. M., Wilson, I. A., Daha, M. R., Dwek, R. A., and Rudd, P. M. (2003). Secretory IgA N-and O-glycans provide a link between the innate and adaptive immune systems. J Biol Chem 278, 20140–20153.
Rudd, P. M., Fortune, F., Patel, T., Parekh, R. B., Dwek, R. A., and Lehner, T. (1994). A human T-cell receptor recognizes ‘O’-linked sugars from the hinge region of human IgA1 and IgD. Immunology 83, 99–106.
Sarmay, G., Lund, J., Rozsnyay, Z., Gergely, J., and Jefferis, R. (1992). Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor. Mol Immunol 29, 633–639.
Shields, R. L., Namenuk, A. K., Hong, K., Meng, Y. G., Rae, J., Briggs, J., Xie, D., Lai, J., Stadlen, A., Li, B., et al. (2001). High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 276, 6591–6604.
Sim, R. B., Moestrup, S. K., Stuart, G. R., Lynch, N. J., Lu, J., Schwaeble, W. J., and Malhotra, R. (1998). Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin. Immunobiology 199, 208–224.
Sorensen, V., Sundvold, V., Michaelsen, T. E., and Sandlie, I. (1999). Polymerization of IgA and IgM: roles of Cys309/Cys414 and the secretory tailpiece. J Immunol 162, 3448–3455.
Stockert, R. J. (1995). The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol Rev 75, 591–609.
Sumiya, M., Super, M., Tabona, P., Levinsky, R. J., Arai, T., Turner, M. W., and Summerfield, J. A. (1991). Molecular basis of opsonic defect in immunodeficient children. Lancet 337, 1569–1570.
Summerfield, J. A., Sumiya, M., Levin, M., and Turner, M. W. (1997). Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. Bmj 314, 1229–1232.
Takahashi, N., Tetaert, D., Debuire, B., Lin, L. C., and Putnam, F. W. (1982). Complete amino acid sequence of the delta heavy chain of human immunoglobulin D. Proc Natl Acad Sci U S A 79, 2850–2854.
Takayasu, T., Suzuki, S., Kametani, F., Takahashi, N., Shinoda, T., Okuyama, T., and Munekata, E. (1982). Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D. Biochem Biophys Res Commun 105, 1066–1071.
Tarelli, E., Smith, A. C., Hendry, B. M., Challacombe, S. J., and Pouria, S. (2004). Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry. Carbohydr Res 339, 2329–2335.
Tarentino, A. L., Plummer, T. H., Jr., and Maley, F. (1974). The release of intact oligosaccharides from specific glycoproteins by endo-beta-N-acetylglucosaminidase H. J Biol Chem 249, 818–824.
Thiel, S., Vorup-Jensen, T., Stover, C. M., Schwaeble, W., Laursen, S. B., Poulsen, K., Willis, A. C., Eggleton, P., Hansen, S., Holmskov, U., et al. (1997). A second serine protease associated with mannan-binding lectin that activates complement. Nature 386, 506–510.
Turner, M. W. (1996). Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today 17, 532–540.
Valdimarsson, H., Stefansson, M., Vikingsdottir, T., Arason, G. J., Koch, C., Thiel, S., and Jensenius, J. C. (1998). Reconstitution of opsonizing activity by infusion of mannan-binding lectin (MBL) to MBL-deficient humans. Scand J Immunol 48, 116–123.
Van Boxel, J. A., Paul, W. E., Terry, W. D., and Green, I. (1972). Communications. IgD-bearing human lymphocytes. J Immunol 109, 648–651.
Vorup-Jensen, T., Petersen, S. V., Hansen, A. G., Poulsen, K., Schwaeble, W., Sim, R. B., Reid, K. B., Davis, S. J., Thiel, S., and Jensenius, J. C. (2000). Distinct pathways of mannan-binding lectin (MBL)-and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2. J Immunol 165, 2093–2100.
Wan, T., Beavil, R. L., Fabiane, S. M., Beavil, A. J., Sohi, M. K., Keown, M., Young, R. J., Henry, A. J., Owens, R. J., Gould, H. J., and Sutton, B. J. (2002). The crystal structure of IgE Fc reveals an asymmetrically bent conformation. Nat Immunol 3, 681–686.
Weis, W. I., Drickamer, K., and Hendrickson, W. A. (1992). Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature 360, 127–134.
Wiersma, E. J., Collins, C., Fazel, S., and Shulman, M. J. (1998). Structural and functional analysis of J chain-deficient IgM. J Immunol 160, 5979–5989.
Wormald, M. R., Rudd, P. M., Harvey, D. J., Chang, S. C., Scragg, I. G., and Dwek, R. A. (1997). Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides. Biochemistry 36, 1370–1380.
Wormald, M. R., Wooten, E. W., Bazzo, R., Edge, C. J., Feinstein, A., Rademacher, T. W., and Dwek, R. A. (1991). The conformational effects of N-glycosylation on the tailpiece from serum IgM. Eur J Biochem 198, 131–139.
Youings, A., Chang, S. C., Dwek, R. A., and Scragg, I. G. (1996). Site-specific glycosylation of human immunoglobulin G is altered in four rheumatoid arthritis patients. Biochem J 314 (Pt 2), 621–630.
Zhu, D., McCarthy, H., Ottensmeier, C. H., Johnson, P., Hamblin, T. J., and Stevenson, F. K. (2002). Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 99, 2562–2568.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer
About this paper
Cite this paper
Arnold, J.N., Royle, L., Dwek, R.A., Rudd, P.M., Sim, R.B. (2005). Human Immunoglobulin Glycosylation and the Lectin Pathway of Complement Activation. In: Axford, J.S. (eds) Glycobiology and Medicine. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25515-X_9
Download citation
DOI: https://doi.org/10.1007/0-387-25515-X_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25514-9
Online ISBN: 978-0-387-25515-6
eBook Packages: MedicineMedicine (R0)