Skip to main content
SpringerLink
Log in
Book cover

Fungal Immunology pp 113–133Cite as

Lung Immunity to Blastomyces dermatitidis Infection

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allendoerfer, R. and Deepe, G.S. Jr. (1998). Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. J. Immunol. 160: 6072–6082.

    CAS  PubMed  Google Scholar 

  • Bradsher, R.W. (1996). Histoplasmosis and blastomycosis. Clin. Infect. Dis. 22(Suppl. 2): S102–S111.

    PubMed  Google Scholar 

  • Bradsher, R.W., Balk, R.A., and Jacobs, R.F. (1987). Growth inhibition of Blastomyces dermatitidis in alveolar and peripheral macrophages from patients with blastomycosis. Am. Rev. Respir. Dis. 135: 412–417.

    CAS  PubMed  Google Scholar 

  • Brandhorst, T. and Klein, B. (2000). Cell wall biogenesis of Blastomyces dermatitidis. Evidence for a novel mechanism of cell surface localization of a virulence-associated adhesin via extracellular release and reassociation with cell wall chitin. J. Biol. Chem. 275: 7925–7934.

    Article  CAS  PubMed  Google Scholar 

  • Brandhorst, T.T., Wüthrich, M., Warner, T., and Klein, B. (1999). Targeted gene disruption reveals an adhesin indispensable for pathogenicity of Blastomyces dermatitidis. J. Exp. Med. 189: 1207–1216.

    CAS  PubMed  Google Scholar 

  • Brandhorst, T., Wüthrich, M., Finkel-Jimenez, B., and Klein, B. (2003). A C-terminal EGF-like domain governs BAD1 localization to the yeast surface and fungal adherence to phagocytes, but is dispensable in immune modulation and pathogenicity of Blastomyces dermatitidis. Mol. Microbiol. 48: 53–65.

    Article  CAS  PubMed  Google Scholar 

  • Brass, C., Volkmann, C.M., Philpott, D.E., Klein, H.P., Halde, C.J., and Stevens, D.A. (1982). Spontaneous mutant of Blastomyces dermatitidis attenuated in virulence for mice. Sabouraudia 20: 145–158.

    CAS  PubMed  Google Scholar 

  • Brummer, E. and Stevens, D.A. (1987). Activation of pulmonary macrophages for fungicidal activity by gamma-interferon or lymphokines. Clin. Exp. Immunol. 70: 520–528.

    CAS  PubMed  Google Scholar 

  • Brummer, E., Hanson, L.H., Restrepo, A., and Stevens, D.A. (1988). In vivo and in vitro activation of pulmonary macrophages by IFN-gamma for enhanced killing of Paracoccidioides brasiliensis or Blastomyces dermatitidis. J. Immunol. 140: 2786–2789.

    CAS  PubMed  Google Scholar 

  • Cassone, A., Boccanera, M., Adriani, D., Santoni, G., and De Bernardis, F. (1995). Rats clearing a vaginal infection by Candida albicans acquire specific, antibody-mediated resistance to vaginal reinfection. Infect. Immun. 63: 2619–2624.

    CAS  PubMed  Google Scholar 

  • Cozad, G.C. and Chang, C.T. (1980). Cell-mediated immunoprotection in blastomycosis. Infect. Immun. 28: 398–403.

    CAS  PubMed  Google Scholar 

  • Diamond, R.D. and Krzesicki, R. (1978). Mechanisms of attachment of neutrophils to Candida albicans pseudohyphae in the absence of serum, and of subsequent damage to pseudohyphae by microbicidal processes of neutrophils in vitro. J. Clin. Invest. 61: 360–369.

    CAS  Google Scholar 

  • Diamond, R.D., Krzesicki, R., and Jao, W. (1978). Damage to pseudohyphal forms of Candida albicans by neutrophils in the absence of serum in vitro. J. Clin. Invest. 61: 349–359.

    CAS  PubMed  Google Scholar 

  • Dromer, F. and Charreire, J. (1991). Improved amphotericin B activity by a monoclonal anti-Cryptococcus neoformans antibody: Study during murine cryptococcosis and mechanisms of action. J. Infect. Dis. 163: 1114–1120.

    CAS  PubMed  Google Scholar 

  • Dromer, F., Charreire, J., Contrepois, A., Carbon, C., and Yeni, P. (1987). Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody. Infect. Immun. 55: 749–752.

    CAS  PubMed  Google Scholar 

  • Dromer, F., Perronne, C., Barge, J., Vilde, J.L., and Yeni, P. (1989). Role of IgG and complement component C5 in the initial course of experimental cryptococcosis. Clin. Exp. Immunol. 78: 412–417.

    CAS  PubMed  Google Scholar 

  • Drutz, D.J. and Frey, C.L. (1985). Intracellular and extracellular defenses of human phagocytes against Blastomyces dermatitidis conidia and yeasts. J. Lab. Clin. Med. 105: 737–750.

    CAS  PubMed  Google Scholar 

  • Falkow, S. (1988). Molecular Koch’s postulates applied to microbial pathogenicity. Rev. Infect. Dis. 10(Suppl. 2): S274–S276.

    PubMed  Google Scholar 

  • Finkel-Jimenez, B., Wüthrich, M., Brandhorst, T., and Klein, B.S. (2001). The WI-1 adhesin blocks phagocyte TNF-alpha production, imparting pathogenicity on Blastomyces dermatitidis. J. Immunol. 166: 2665–2673.

    CAS  PubMed  Google Scholar 

  • Finkel-Jimenez, B., Wüthrich, M., and Klein, B.S. (2002). BAD1, an essential virulence factor of Blastomyces dermatitidis, suppresses host TNF-alpha production through TGF-beta-dependent and-independent mechanisms. J. Immunol. 168: 5746–5755.

    CAS  PubMed  Google Scholar 

  • Galan, J.E. and Collmer, A. (1999). Type III secretion machines: Bacterial devices for protein delivery into host cells. Science 284: 1322–1328.

    CAS  PubMed  Google Scholar 

  • Gigliotti, F. and Hughes, W.T. (1988). Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models. J. Clin. Invest. 81: 1666–1668.

    CAS  PubMed  Google Scholar 

  • Hamilton, S.E., Tvinnereim, A.R., and Harty, J.T. (2001). Listeria monocytogenes infection overcomes the requirement for CD40 ligand in exogenous antigen presentation to CD8(+) T cells. J. Immunol. 167: 5603–5609.

    CAS  PubMed  Google Scholar 

  • Harvey, R.P., Schmid, E.S., Carrington, C.C., and Stevens, D.A. (1978). Mouse model of pulmonary blastomycosis: Utility, simplicity, and quantitative parameters. Am. Rev. Respir. Dis. 117: 695–703.

    CAS  PubMed  Google Scholar 

  • Hogan, L.H. and Klein, B.S. (1994). Altered expression of surface alpha-1,3-glucan in genetically related strains of Blastomyces dermatitidis that differ in virulence. Infect. Immun. 62: 3543–3546.

    CAS  PubMed  Google Scholar 

  • Hogan, L.H. and Klein, B.S. (1997). Transforming DNA integrates at multiple sites in the dimorphic fungal pathogen Blastomyces dermatitidis. Gene 186: 219–226.

    Article  CAS  PubMed  Google Scholar 

  • Hogan, L.H., Josvai, S., and Klein, B.S. (1995). Genomic cloning, characterization, and functional analysis of the major surface adhesion WI-1 on Blastomyces dermatitidis yeasts. J. Biol. Chem. 270: 30725–30732.

    CAS  PubMed  Google Scholar 

  • Hogan, L.H., Klein, B.S., and Levitz, S.M. (1996). Virulence factors of medically important fungi. Clin. Microbiol. Rev. 9: 469–488.

    CAS  PubMed  Google Scholar 

  • Jung, S., Unutmaz, D., Wong, P., Sano, G., De los Santos, K., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., Pamer, E.G., Littman, D.R., and Lang, R.A. (2002). In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17: 211–220.

    Article  CAS  PubMed  Google Scholar 

  • Klein, B.S. and Jones, J.M. (1990). Isolation, purification, and radiolabeling of a novel 120-kDa surface protein on Blastomyces dermatitidis yeasts to detect antibody in infected patients. J. Clin. Invest. 85: 152–161.

    CAS  PubMed  Google Scholar 

  • Klein, B.S. and Newman, S.L. (1996). Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions. Trends Microbiol. 4: 246–251.

    Article  CAS  PubMed  Google Scholar 

  • Klein, B.S., Vergeront, J.M., and Davis, J.P. (1986). Epidemiologic aspects of blastomycosis, the enigmatic systemic mycosis. Sem. Respir. Infect. 1: 29–39.

    CAS  Google Scholar 

  • Klein, B.S., Sondel, P.M., and Jones, J.M. (1992). WI-1, a novel 120-kilodalton surface protein on Blastomyces dermatitidis yeast cells, is a target antigen of cell-mediated immunity in human blastomycosis. Infect. Immun. 60: 4291–4300.

    CAS  PubMed  Google Scholar 

  • Klein, B.S., Hogan, L.H., and Jones, J.M. (1993). Immunologic recognition of a 25-amino acid repeat arrayed in tandem on a major antigen of Blastomyces dermatitidis. J. Clin. Invest. 92: 330–337.

    CAS  PubMed  Google Scholar 

  • Klein, B.S., Chaturvedi, S., Hogan, L.H., Jones, J.M., and Newman, S.L. (1994). Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages. Infect. Immun. 62: 3536–3542.

    CAS  PubMed  Google Scholar 

  • Klein, B.S., Squires, R.A., Lloyd, J.K., Ruge, D.R., and Legendre, A.M. (2000). Canine antibody response to Blastomyces dermatitidis WI-1 antigen. Am. J. Vet. Res. 61: 554–558.

    Article  CAS  PubMed  Google Scholar 

  • Kundig, T.M., Shahinian, A., Kawai, K., Mittrucker, H.W., Sebzda, E., Bachmann, M.F., Mak, T.W., and Ohashi, P.S. (1996). Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5: 41–52.

    Article  CAS  PubMed  Google Scholar 

  • Levitz, S.M., Mathews, H.L., and Murphy, J.W. (1995). Direct antimicrobial activity of T cells. Immunol. Today 16: 387–391.

    Article  CAS  PubMed  Google Scholar 

  • Morozumi, P.A., Brummer, E., and Stevens, D.A. (1982). Protection against pulmonary blastomycosis: Correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection. Infect. Immun. 37: 670–678.

    CAS  PubMed  Google Scholar 

  • Morrison, C.J. and Stevens, D.A. (1991). Mechanisms of fungal pathogenicity: Correlation of virulence in vivo, susceptibility to killing by polymorphonuclear neutrophils in vitro, and neutrophil superoxide anion induction among Blastomyces dermatitidis isolates. Infect. Immun. 59: 2744–2749.

    CAS  PubMed  Google Scholar 

  • Mukherjee, J., Scharff, M.D., and Casadevall, A. (1992). Protective murine monoclonal antibodies to Cryptococcus neoformans. Infect. Immun. 60: 4534–4541.

    CAS  PubMed  Google Scholar 

  • Mukherjee, J., Casadevall, A., and Scharff, M.D. (1993a). Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization. J. Exp. Med. 177: 1105–1116.

    Article  CAS  PubMed  Google Scholar 

  • Mukherjee, J., Pirofski, L.A., Scharff, M.D., and Casadevall, A. (1993b). Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection. Proc. Natl. Acad. Sci. USA 90: 3636–3640.

    CAS  PubMed  Google Scholar 

  • Mukherjee, J., Scharff, M.D., and Casadevall, A. (1994a). Cryptococcus neoformans infection can elicit protective antibodies in mice. Can. J. Microbiol. 40: 888–892.

    CAS  PubMed  Google Scholar 

  • Mukherjee, S., Lee, S., Mukherjee, J., Scharff, M.D., and Casadevall, A. (1994b). Monoclonal antibodies to Cryptococcus neoformans capsular polysaccharide modify the course of intravenous infection in mice. Infect. Immun. 62: 1079–1088.

    CAS  PubMed  Google Scholar 

  • Newman, S.L., Chaturvedi, S., and Klein, B.S. (1995). The WI-1 antigen of Blastomyces dermatitidis yeasts mediates binding to human macrophage CD11b/CD18 (CR3) and CD14. J. Immunol. 154: 753–761.

    CAS  PubMed  Google Scholar 

  • Pasparakis, M., Alexopoulou, L., Douni, E., and Kollias, G. (1996). Tumour necrosis factors in immune regulation: Everything that’s interesting is... new! Cytokine Growth Factor Rev. 7:223–229.

    Article  CAS  PubMed  Google Scholar 

  • Polonelli, L., De Bernardis, F., Conti, S., Boccanera, M., Gerloni, M., Morace, G., Magliani, W., Chezzi, C., and Cassone, A. (1994). Idiotypic intravaginal vaccination to protect against candidal vaginitis by secretory, yeast killer toxin-like anti-idiotypic antibodies. J. Immunol. 152: 3175–3182.

    CAS  PubMed  Google Scholar 

  • Reis e Sousa, C., Sher, A., and Kaye, P. (1999). The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr. Opin. Immunol. 11: 392–399.

    CAS  PubMed  Google Scholar 

  • Ronchetti, A., Rovere, P., Iezzi, G., Galati, G., Heltai, S., Protti, M.P., Garancini, M.P., Manfredi, A.A., Rugarli, C., and Bellone, M. (1999). Immunogenicity of apoptotic cells in vivo: Role of antigen load, antigen-presenting cells, and cytokines. J. Immunol. 163: 130–136.

    CAS  PubMed  Google Scholar 

  • Rooney, P.J., Sullivan, T.D., and Klein, B.S. (2001). Selective expression of the virulence factor BAD1 upon morphogenesis to the pathogenic yeast form of Blastomyces dermatitidis: Evidence for transcriptional regulation by a conserved mechanism. Mol. Microbiol. 39: 875–889.

    Article  CAS  PubMed  Google Scholar 

  • Sanford, J.E., Lupan, D.M., Schlageter, A.M., and Kozel, T.R. (1990). Passive immunization against Cryptococcus neoformans with an isotype-switch family of monoclonal antibodies reactive with cryptococcal polysaccharide. Infect. Immun. 58: 1919–1923.

    CAS  PubMed  Google Scholar 

  • Schaffner, A., Davis, C.E., Schaffner, T., Markert, M., Douglas, H., and Braude, A.I. (1986). In vitro susceptibility of fungi to killing by neutrophil granulocytes discriminates between primary pathogenicity and opportunism. J. Clin. Invest. 78: 511–524.

    CAS  PubMed  Google Scholar 

  • Scillian, J.J., Cozad, G.C., and Spencer, H.D. (1974). Passive transfer of delayed hypersensitivity to Blastomyces dermatitidis between mice. Infect. Immun. 10: 705–711.

    CAS  PubMed  Google Scholar 

  • Shedlock, D.J., Whitmire, J.K., Tan, J., MacDonald, A.S., Ahmed, R., and Shen, H. (2003). Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection. J. Immunol. 170: 2053–2063.

    CAS  PubMed  Google Scholar 

  • Shen, H., Whitmire, J.K., Fan, X., Shedlock, D.J., Kaech, S.M., and Ahmed, R. (2003). A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J. Immunol. 170: 1443–1451.

    CAS  PubMed  Google Scholar 

  • Sixbey, J.W., Fields, B.T., Sun, C.N., Clark, R.A., and Nolan, C.M. (1979). Interactions between human granulocytes and Blastomyces dermatitidis. Infect. Immun. 23: 41–44.

    CAS  PubMed  Google Scholar 

  • Spencer, H.D. and Cozad, G.C. (1973). Role of delayed hypersensitivity in blastomycosis of mice. Infect. Immun. 7: 329–334.

    CAS  PubMed  Google Scholar 

  • Sugar, A. and Field, K. (1987a). Production of superoxide (O −2 ) by Blastomyces dermatitidis conidia and murine bronchoalveolar macrophages stimulated with conidia. Clin. Res. 35: 493A.

    Google Scholar 

  • Sugar, A. and Field, K. (1987b). Production of superoxide (O −2 ) by Blastomyces dermatitidis (Bd) yeast forms and challenged murine bron-choalveolar macrophages (BAM). Abstr. Annu. Meet. ASM F45: 396.

    Google Scholar 

  • Sugar, A.M. and Picard, M. (1991). Macrophage-and oxidant-mediated inhibition of the ability of live Blastomyces dermatitidis conidia to transform to the pathogenic yeast phase: Implications for the pathogenesis of dimorphic fungal infections. J. Infect. Dis. 163: 371–375.

    CAS  PubMed  Google Scholar 

  • Whitmire, J.K., Slifka, M.K., Grewal, I.S., Flavell, R.A., and Ahmed, R. (1996). CD40 lig-and-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection. J. Virol. 70: 8375–8381.

    CAS  PubMed  Google Scholar 

  • Wüthrich, M. and Klein, B.S. (2000). Investigation of anti-WI-1 adhesin antibody-mediated protection in experimental pulmonary blastomycosis. J. Infect. Dis. 181: 1720–1728.

    Article  PubMed  Google Scholar 

  • Wüthrich, M., Chang, W.L., and Klein, B.S. (1998). Immunogenicity and protective efficacy of the WI-1 adhesin of Blastomyces dermatitidis. Infect. Immun. 66: 5443–5449.

    PubMed  Google Scholar 

  • Wüthrich, M., Filutowicz, H.I., and Klein, B.S. (2000). Mutation of the WI-1 gene yields an attenuated Blastomyces dermatitidis strain that induces host resistance. J. Clin. Invest. 106: 1381–1389.

    PubMed  Google Scholar 

  • Wüthrich, M., Filutowicz, H.I., Warner, T., and Klein, B.S. (2002). Requisite elements in vaccine immunity to Blastomyces dermatitidis: Plasticity uncovers vaccine potential in immune-deficient hosts. J. Immunol. 169: 6969–6976.

    PubMed  Google Scholar 

  • Wüthrich, M., Filutowicz, H.I., Warner, T., Deepe, G.S. Jr., and Klein, B.S. (2003). Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: Implications for vaccine development in immune-deficient hosts. J. Exp. Med. 197: 1405–1416.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, 53792

    Marcel Wüthrich & Bruce S. Klein

  2. Department of Internal Medicine, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, 53792

    Bruce S. Klein

  3. Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, 53792

    Bruce S. Klein

  4. Comprehensive Cancer Center, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI, 53792

    Bruce S. Klein

Authors
  1. Marcel Wüthrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bruce S. Klein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana

    Paul L. Fidel Jr.

  2. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan

    Gary B. Huffnagle

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Wüthrich, M., Klein, B.S. (2005). Lung Immunity to Blastomyces dermatitidis Infection. In: Fidel, P.L., Huffnagle, G.B. (eds) Fungal Immunology. Springer, Boston, MA. https://doi.org/10.1007/0-387-25445-5_6

Download citation

Publish with us

Policies and ethics

Search

Navigation