Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allen, H.E., Crompton, D.W., de Silva, N., LoVerde, P.T., and Olds, G.R., 2002, New policies for using anthelmintics in high risk groups, Trends Parasitol. 18:381–382.
Archer, S., Pica-Mattoccia, L., Cioli, D., Seyed-Mozaffari, A., and Zayed, A.H., 1988, Preparation and antischistosomal and antitumor activity of hycanthone and some of its congeners. Evidence for the mode of action of hycanthone, J. Med. Chem. 31:254–260.
Becker, B., Mehlorn, H., Andrews, P., Thomas, H., and Eckert, J., 1980, Light and electron microscopic studies on the effect of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum, and Fasciola hepatica (Trematoda) in vitro, Z. Parasitenk 63:113–118.
Bricker, C.S., Depenbusch, J.W., Bennett, J.L., and Thompson, D.P., 1983, The relationship between tegumental disruption and muscle contraction in Schistosoma mansoni exposed to various compounds, Z. Parasitenk 69:61–71.
Brindley, P.J., and Sher, A. 1987, The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response, J. Immunol. 139:215–220.
Cioli, D., 1998, Chemotherapy of schistosomiasis: An update, Parasitol. Today 14:418–422.
Cioli, D., 2000, Praziquantel: is there real resistance and are there alternatives?, Curr. Op. Inf. Dis. 13:659–663.
Cioli, D., and Knopf, P.M., 1998, A study of the mode of action of hycanthone against Schistosoma mansoni in vivo and in vitro, Am. J. Trop. Med. Hyg. 29:220–226.
Cioli, D., Pica-Mattoccia, L., and Archer, S., 1995, Antischistosomal drugs: past, present … and future? Pharmacol. Ther. 68:35–85.
Cioli, D., Pica-Mattoccia, L., and Moroni, R., 1992, Schistosoma mansoni: Hycanthone/ oxamniquine resistance is controlled by a single autosomal recessive gene. Exp. Parasitol. 75:425–432.
Cioli, D., Pica-Mattoccia, L., Rosenberg, S., and Archer, S., 1985, Evidence for the mode of antischistosomal action of hycanthone, Life Sci. 37:161–167.
Doenhoff, M.J., Sabah, A.A., Fletcher, C., Webbe, G., and Bain, J., 1987, Evidence for an immune-dependent action of praziquantel on Schistosoma mansoni in mice, Trans. R. Soc. Trop. Med. Hyg. 81:947–951.
Doenhoff, M.J., Kusel, J.R., Coles, G.C., and Cioli, D., 2002, Resistance of Schistosoma mansoni to praziquantel: is there a problem? Trans. R. Soc. Trop. Med. Parasitol. 96:465–469.
Fallon, P.G., and Doenhoff, M.J., 1994, Drug-resistant schistosomiasis: Resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific. Am. J. Trop. Med. Hyg. 51:83–88.
Fallon, P.G., Sturrock, R.F., Capron, A., Niang, M., and Doenhoff, M.J., 1995, Short report: Diminished susceptibility to praziquantel in a Senegal isolate of Schistosoma mansoni, Am. J. Trop. Med. Hyg. 53:61–62.
Fetterer, R.H., Pax, R.A., and Bennett, J.L., 1980, Praziquantel, potassium and 2,4-dinitrophenol: analysis of their action on the musculature of Schistosoma mansoni, Eur. J. Pharmacol. 64:31–38.
Frohberg, H., 1984, Results of toxicological studies on praziquantel. Arzneim. Forsch. 34:1137–1144.
Gönnert, R., and Andrews, P., 1977, Praziquantel, a new broad-spectrum antischistosomal agent, Z. Parasitenk 52:129–150.
Gryseels, B., Mbaye, A., De Vlas, S.J., Stelma, F.F., Guissé, F., Van Lieshout, L., Faye, D., Diop, M., Ly, A., Tchuem-Tchuente, L.A., Engels, D., and Polman, K., 2002, Are poor responses to praziquantel for the treatment of Schistosoma mansoni infections in Senegal due to resistance? An overview of the evidence, Trop. Med. Intl. Health 6:864–873.
Gryseels, B., Stelma, F.F., Tall,a I., van Dam, G.J., Polman, K., Sow, S., Diaw, M., Sturrock, R.F., Doehring-Scwerdtfeger, E., Kardoff, R., Decam, C., Niang, M., and Deelder A.M., 1994, Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal, Trop. Geogr. Med. 46:209–219.
Harder, A., Goossens, J., and Andrews, P., 1988, Influence of praziquantel and Ca2+ on the bilayer-isotropic-hexagonal transition of model membranes, Mol. Biochem. Parasitol. 29:55–60.
Ismail, M., Botros, S., Metwally, A., William, S., Farghally, A., Tao, L.F., Day, T.A., and Bennett, J.L., 1999, Resistance to praziquantel: Direct evidence from Schistosoma mansoni isolated from Egyptian villagers, Am. J. Trop. Med. Hyg. 60:932–935.
Ismail, M., Metwally, A., Farghaly, A., Bruce, J., Tao, L.F., and Bennett J.L., 1996, Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel, Am. J. Trop. Med. Hyg. 55:214–218.
Karanja, D.M., Boyer, A.E., Strand, M., Colley, D.G., Nahlen, B.L., Ouma, J.H., and Secor, W.E., 1998, Studies on schistosomiasis in western Kenya: II. Efficacy of praziquantel for treatment of schistosomiasis in persons coinfected with human immunodeficiency virus-1, Am. J. Trop. Med. Hyg. 59:307–311.
Katz, N., Dias, E.P., Araujo, N., and Souza, C.P., 1973, Estudo de uma cepa humana de Schistosoma mansoni resistente a agentes esquistossomicidas, Rev. Soc. Bras. Med. Trop. 7:381–387.
Kohn, A.B., Anderson, P.A., Roberts-Misterly, J.M., and Greenberg, R.M., 2001, Schistosome calcium channel beta subunits. Unusual modulatory effects and potential role in the action of the antischistosomal drug praziquantel. J. Biol. Chem. 276:36873–36876.
Kramers, P.G.N., Gentile, J.M., Gryseels, B.J.M., Jordan, P., Katz, N., Mott, K.E., Mulvihill, J.J., Seed, J.L., and Frohberg, H., 1991, Review of the genotoxicity and carcinogenicity of antischistosomal drugs; is there a case for a study of mutation epidemiology? Report of a task group on mutagenic antischistosomals, Mutation Res. 257:49–89.
McTigue, M.A., Williams, D.R., and Tainer, J.A., 1995, Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel, J. Mol. Biol. 246:21–27.
Milhon, J.L., Thiboldeaux, R.L., Glowac, K., and Tracy, J.W., 1997, Schistosoma japonicum GSH S-transferase Sj26 is not the molecular target of praziquantel action, Exp. Parasitol. 87:268–274.
Nechay, B.R., Hillman, G.R., and Dotson, M.J., 1980, Properties and drug sensitivity of adenosine triphosphatases from Schistosoma mansoni, J. Parasitol. 66:596–600.
Pax, R., Bennett, J.L., and Fetterer, R., 1978, A benzodiazepine derivative and praziquantel: Effects on musculature of Schistosoma mansoni and Schistosoma japonicum, Naunyn-Schiedberg’s Arch. Pharmacol. 304:309–315.
Pica-Mattoccia, L., and Cioli, D., 1986, Lack of correlation between schistosomicidal and anticholinergic properties of hycanthone and related drugs, J. Parasitol. 72:531–539.
Pica-Mattoccia, L., Archer, S., and Cioli, D., 1992, Hycanthone resistance in schistosomes correlates with the lack of an enzymatic activity which produces the covalent binding of hycanthone to parasite macromolecules, Mol. Biochem. Parasitol. 55:167–176.
Pica-Mattoccia, L., Cioli, D., and Archer, S., 1989, Binding of oxamniquine to the DNA of schistosomes, Trans. R. Soc. Trop. Med. Hyg. 83:89–96.
Pica-Mattoccia L., Cioli D. Sex-and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. Intl J Parasitol 2004, in press.
Pica-Mattoccia, L., Dias, L.C.S., Moroni, R., and Cioli, D., 1993, Schistosoma mansoni: Genetic complementation analysis shows that two independent hycanthone/oxamniquineresistant strains are mutated in the same gene, Exp. Parasitol. 77:445–449.
Pica-Mattoccia, L., Novi, A., and Cioli, D., 1997, The enzymatic basis for the lack of oxamniquine activity in Schistosoma haematobium infections, Parasitol. Res. 83:687–689.
Rogers, S.H., and Bueding, E., 1971, Hycanthone resistance: Development in Schistosoma mansoni, Science 172:1057–1058.
Sabah, A.A., Fletcher, C., Webbe, G., and Doenhoff, M.J., 1985, Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell-deprived mice, Exp. Parasitol. 60:348–354.
Sabah, A.A., Fletcher, C., Webbe, G., and Doenhoff, M.J., 1986, Schistosoma mansoni: chemotherapy of infections of different ages, Exp. Parasitol. 61:294–303.
Sauma, S.Y., and Strand, M., 1990, Identification and characterization of glycophosphatidylinositol-linked Schistosoma mansoni adult worm immunogens, Mol. Biochem. Parasitol. 38:199–210.
Schepers, H., Brasseur, R., Goormaghtigh, E., Duquenoy, P., and Ruysschaert, J.M., 1988, Mode of insertion of praziquantel and derivatives into lipid membranes. Biochem. Pharmacol. 37:1615–1623.
Stelma, F.F., Talla, I., Sow, S., Kongs, A., Niang, M., Polman, K., Deelder, A.M., and Gryseels, B., 1995, Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni, Am. J. Trop. Med. Hyg. 53:167–170.
Sulaiman, S.M., Traoré, M., Engels, D., Hagan, P., and Cioli, D., 2001, Counterfeit praziquantel, Lancet 358:666–667.
Valle, C., Troiani, A.R., Festucci, A., Pica-Mattoccia, L., Liberti, P., Wolstenholme, A., Francklow, K., Doenhoff, M.J., and Cioli, D., 2003, Sequence and level of endogenous expression of calcium channel β subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel, Mol. Biochem. Parasitol. 130:111–115.
Waring, M. J., 1970, Variation in the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation, J. Mol. Biol. 54:247–279.
Watabe, T., Ishizuka, T., Isobe, M., and Ozawa, N., 1982, A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[a]anthracene, Science 215:403–405.
Wu, M.H., Wei, C.C., Xu, Z.Y., Yuan, H.C., Lian, W.N., Yang, Q.J., Chen, M., Jiang, Q.W., Wang, C.Z., and Zhang, S.J., 1991, Comparison of the therapeutic efficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica, Am. J. Trop. Med. Hyg. 45:345–349.
Xiao, S.H., Catto, B.A., and Webster, L.T., 1985, Effects of praziquantel on different developmental stages of Schistosoma mansoni in vitro and in vivo, J. Inf. Dis. 151:1130–1137.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer Science + Business Media, Inc.
About this chapter
Cite this chapter
Cioli, D., Pica-Mattoccia, L. (2005). Current and Future Antischistosomal Drugs. In: Secor, W.E., Colley, D.G. (eds) Schistosomiasis. World Class Parasites, vol 10. Springer, Boston, MA. https://doi.org/10.1007/0-387-23362-8_13
Download citation
DOI: https://doi.org/10.1007/0-387-23362-8_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-23277-5
Online ISBN: 978-0-387-23362-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)