Skip to main content
SpringerLink
Log in
Book cover

Ocular Surface Disease Medical and Surgical Management pp 100–112Cite as

Chemical and Thermal Injuries to the Ocular Surface

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Pfister R, Pfister D. Alkali-Injuries of the eye. In: Krachmer M, Mannis M, Holland E, editors. Cornea and External Disease: Clinical Diagnosis and Management. St. Louis: Mosby-Year Book, 1997:1443–1451.

    Google Scholar 

  2. Arffa R. Chemical injuries. In: Grayson’s diseases of the cornea. St. Louis: Mosby-Year Book, 1991:649–665.

    Google Scholar 

  3. Kuckelkorn R, Luft I, Kottek AA. Chemical and thermal eye burns in the residential area of RWTH Aachen. Analysis of accidents in 1 year using a new automated documentation of findings. Klin Monatsbl Augenheilkd 1993; 203:397–402.

    CAS  PubMed  Google Scholar 

  4. Wagoner M. Chemical Injuries of the Eye: current concepts in pathophysiology and therapy. Surv Ophthalmol 1997; 41:276–313.

    Google Scholar 

  5. Morgan S. Chemical burns of the eye: causes and management. Br J Ophthalmol 1987;71:854–857.

    CAS  PubMed  Google Scholar 

  6. Pfister R. Collagenase activity of intact corneal epithelium in peripheral alkaline burns. Arch Ophthalmol 1971;86: 308–310.

    CAS  PubMed  Google Scholar 

  7. Grant W, Schuman J. Toxicology of the Eye, 4th ed. Springfield: Charles C. Thomas, 1993.

    Google Scholar 

  8. Harris L, Cohn K, Galin M. Alkali injury in fireworks. Ann Ophthalmol 1971;3:849–851.

    CAS  PubMed  Google Scholar 

  9. McCulley J. Chemical injuries. In: Smolin G and Thoft R, editors. The Cornea: Scientific Foundation and Clinical Practice. Boston, Little, Brown, and Co, 1987:527–542.

    Google Scholar 

  10. Cejkova J. Alkali burns of the rabbit cornea. A histochemical study of glycosaminoglycans. Histochemistry 1975;45:71–75.

    Article  CAS  PubMed  Google Scholar 

  11. Pfister R. Chemical injuries of the eye. Ophthalmology 1983; 90:1246–1253.

    CAS  PubMed  Google Scholar 

  12. Nelson J, Wright J. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol 1984;102:1049–1051.

    CAS  PubMed  Google Scholar 

  13. Ohji M. Goblet cell density in thermal and chemical injuries. Arch Ophthalmol 1987;105:1686–1688.

    CAS  PubMed  Google Scholar 

  14. Paterson C, Pfister R, Levinson R. Aqueous humor pH changes after experimental alkali burns. Am J Ophthalmol 1975;79:414–419.

    CAS  PubMed  Google Scholar 

  15. Pfister R, Paterson C. Ascorbic acid in the treatment of alkali burns of the eye. Ophthalmology 1980;87:1050–1057.

    CAS  PubMed  Google Scholar 

  16. Levinson R, Paterson C, Pfister R. Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns. Invest Ophthalmol 1976;15:986–988.

    CAS  PubMed  Google Scholar 

  17. Fujisawa K, Katakami C, Yamamoto M. Keratocyte activity during wound healing of alkali-burned cornea. Nippon ganka Gakkai Zasshi 1991;95:59–66.

    CAS  PubMed  Google Scholar 

  18. Kao W, Ebert J, Kao C. Development of monoclonal antibodies recognizing collagenase from rabbit PMN: the presence of this enzyme in ulcerating corneas. Curr Eye Res 1986;5:801–05.

    CAS  PubMed  Google Scholar 

  19. Gordon J, Bauer E, Eisen A. Collagenase in the human cornea: immunologic localization. Arch Ophthalmol 1980; 98:341–45.

    CAS  PubMed  Google Scholar 

  20. Berman M, Dohlman C, Davison F. Characterization of collagenolytic activity in the ulcerating cornea. Exp Eye Res 1971;11:225–27.

    Google Scholar 

  21. Brown S, Weller C. The pathogenesis and treatment of collagenase-induced diseases of the cornea. Trans Am Acad Ophthalmol Otolaryngol 1970;74:375–83.

    CAS  PubMed  Google Scholar 

  22. Johnson-Wint B. Regulation of stromal cell collagenase production in adult rabbit cornea: in vitro stimulation and inhibition by epithelial cell products. Proc Natl Acad Sci USA 1980;77:5531–5535.

    Google Scholar 

  23. Shapiro M, Friend J, Thoft R. Corneal re-epithelialization from the conjunctiva. Invest Ophthalmol Vis Sci 1981; 46:135–142.

    Google Scholar 

  24. Huang A, Tseng S. Corneal epithelial wound healing in the absence of limbal epithelium. Invest Ophthalmol Vis Sci 1991;32:96–105.

    CAS  PubMed  Google Scholar 

  25. Thoft R, Wiley L, Sundarraj N. The multipotential cells of the limbus. Eye 1989;3:109–113.

    PubMed  Google Scholar 

  26. Gartaganis S, Margaritis L, Koliopoulous J. The corneal epithelium basement membrane complexes after alkali burns: an ultrastructural study. Ann Ophthalmol 1987;19: 263–268.

    CAS  PubMed  Google Scholar 

  27. Burnett J, Smith L, Prauss J. Acute inflammatory cells and collagenase in tears of human melting corneas. Invest Ophthalmol Vis Sci 1990;31:107–114.

    Google Scholar 

  28. Hughes W. Alkali burns of the eye. Review of the literature and summary of present knowledge. Arch Ophthalmol 1946;35:423–428.

    Google Scholar 

  29. Roper-Hall M. Thermal and chemical burns. Trans Ophthalmol Soc UK 1965;85:631–633.

    CAS  PubMed  Google Scholar 

  30. Ralph R. Chemical Injuries of the eye. In: Tasman W, Jaeger E. Duane’s Clinical Ophthalmology. Vol. 4. Philadelphia: Lippincott Williams & Wilkins, 1998:1–23.

    Google Scholar 

  31. Grant W, Kern H. Action of alkalies on the corneal stroma. Arch Ophthalmol 1955;54:931–933.

    CAS  Google Scholar 

  32. Pfister R. Identification and synthesis of chemotactic tripeptides from alkali-degraded whole cornea: A study of N-acetyl-Proline-Glycine-Proline and N-methyl-Proline-Glycine-Proline. Invest Ophthalmol Vis Sci 1995;36:1306–1316.

    CAS  PubMed  Google Scholar 

  33. Kim J, Kim J, Na B. Amniotic membrane patching promotes healing and inhibits proteinase activity on wound healing following acutecorneal alkali burn. Experiment Eye Res 2000;70:329–37.

    Article  CAS  Google Scholar 

  34. Donshik P, Berman M, Dohlman C. Effect of topical corticosteroids on ulceration in alkali-burned corneas. Arch Ophthalmol 1978; 96:2117–2120.

    CAS  PubMed  Google Scholar 

  35. Hersch P, Rice B, Baer J. Topical nonsteroidal agents and corneal wound healing. Arch Ophthalmol 1990;68:577–583.

    Google Scholar 

  36. Newsome D, Gross J. Prevention by medroxyprogesterone of perforation of the alkali-burned rabbit cornea: inhibition of collagenolytic activity. Invest Oophthalmol Vis Sci 1988;16:21–31.

    Google Scholar 

  37. Gross J, Azizkhan R, Biswas C. Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone. Proc Natl Acad Sci USA 1981;78: 1176–1180.

    CAS  PubMed  Google Scholar 

  38. Brion M, Lambs L, Berthon G. Metal ion-tetracycline interactions in biological fluids: Part 5. Formation of zinc complexes with tetracycline and some of its derivatives and assessment of their biological significance. Agents Actions 1985;17:229–242.

    Article  CAS  PubMed  Google Scholar 

  39. Lauhio A, Sorsa T, Lindy O. The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis. Arthritis Rheum 1992;35:195–198.

    CAS  PubMed  Google Scholar 

  40. Pfister R, Paterson C, Spiers J. The efficacy of ascorbate treatment after severe experimental alkali-burns depends upon the route of administration. Invest Ophthalmol Vis Sci 1980;19:1526–1529.

    CAS  PubMed  Google Scholar 

  41. Pfister R, Paterson C. Additional clinical and morphological observations on the favorable effect of ascorbate in experimental ocular burns. Invest Ophthalmol Vis Sci 1977; 16:478–487.

    CAS  PubMed  Google Scholar 

  42. Pfister R, Paterson C, Hayes S. Effects of topical 10% ascorbate solution on established corneal ulcers after severe alkali burns. Invest Ophthalmol Vis Sci 1982;22:382–395.

    CAS  PubMed  Google Scholar 

  43. Pfister R, Haddox J, Dodson R. Polymorphonuclear leukocyte inhibition by citrate, other heavy metal chelators, and trifluoperazine: evidence to support calcium binding protein involvement. Invest Ophthalmol Vis Sci 1984;25:955–970.

    CAS  PubMed  Google Scholar 

  44. Pfister R, Nicolaro M, Paterson C. Sodium citrate reduces the incidence of corneal ulcerations and perforations in extreme alkali-burned eyes—acetylcysteine and ascorbate have no favorable effect. Invest Ophthalmol Vis Sci 1980; 21:486–490.

    Google Scholar 

  45. Pfister R, Haddox J, Paterson C. The efficacy of sodium citrate in the treatment of severe alkali burns of the eye is influenced by the route of administration. Cornea 1982; 1:205–211.

    CAS  Google Scholar 

  46. Burns F, Gray R, Paterson C. Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide. Invest Ophthalmol Vis Sci 1990;31:107–114.

    CAS  PubMed  Google Scholar 

  47. Teping C, Reim M. Tenoplasty as a new surgical principle in the early treatment of the most severe chemical eye burns. Klin Monatsbl Augenheilkd 1989;194:1–5.

    CAS  PubMed  Google Scholar 

  48. Brodovsky S, McCarty C, Snibson G. Management of Alkali Burns. Ophthalmol 2000;10:1829–1835.

    Google Scholar 

  49. Darlak K, Miller R, Stack M. Thiol-based inhibitors of mammalian collagenase. J Biol Chem 1990;265:5199–5205.

    CAS  PubMed  Google Scholar 

  50. Paterson C, Wells J, Koklitis P. Recombinant tissue inhibitor of metalloproteinase type-1 suppresses alkali-burn-induced corneal ulceration in rabbits. Invest Ophthalmol Vis Sci 1994;35:677–684.

    CAS  PubMed  Google Scholar 

  51. Reim M, Overkamping B, Kuckelkorn R. 2 years experience with Tenon-plasty. Ophthalmologe 1992;89:524–30.

    CAS  PubMed  Google Scholar 

  52. Kuckelkorn R, Wschrage N, Reim M. Treatment of severe eye burns by tenoplasty. Lancet 1995;345:657–658.

    Article  CAS  PubMed  Google Scholar 

  53. Holland E, Schwartz G. The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea 1996;15:549–556.

    CAS  PubMed  Google Scholar 

  54. Kenyon K, Tseng S. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989;96:709–722.

    CAS  PubMed  Google Scholar 

  55. Gangadhar D, Kenyon K, Wagoner M. The surgical management of chemical ocular injuries: present and future strategies. Inter Ophthalmol Clinics 1995;35:63–69.

    CAS  Google Scholar 

  56. Weise R, Mannis M, Vastine D. Conjunctival transplantation. Autologous and homologous grafts. Arch Ophthalmol 1985;103:1736–1740.

    CAS  PubMed  Google Scholar 

  57. Pfister R. Corneal stem cell disease: concepts, categorization, and treatment by autoand homotransplantation of limbal stem cells. CLAO J 1994;20:64–72.

    CAS  PubMed  Google Scholar 

  58. Kim J, Tseng S. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995;14:473–484.

    CAS  PubMed  Google Scholar 

  59. Shimazaki J, Yang H, Kazuo T. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmol 1997;104: 2068–2076.

    CAS  Google Scholar 

  60. Tsai R, Li L, Chen J. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. New Engl J Med 2000;343:86–93.

    Article  CAS  PubMed  Google Scholar 

  61. Schwab IR, Reyes M, Isseroff RR. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 2000;19(4):421–426.

    Article  CAS  PubMed  Google Scholar 

  62. Kramer S. Late numerical grading of alkali burns to determine keratoplasty prognosis. Trans Am Opthalmol Soc 1983;81:97–100.

    CAS  Google Scholar 

  63. Kuckelkorn R, Wenzel M, Lamprecht J. Autologous transplantation of nasal mucosa after severe chemical and thermal eye burns. Klin Monatsbl Augenheilkd 1994;204:155–161.

    Article  CAS  PubMed  Google Scholar 

  64. Naumann G, Lang G, Rummelt V. Autologous nasal mucosa transplantation in severe bilateral conjunctival mucous deficiency syndrome. Ophthalmology 1990;97:1011–1017.

    CAS  PubMed  Google Scholar 

  65. Yaghouti F, Dohlman C. Innovations in keratoprosthesis: proved and unproved. Int Ophthalmol Clin 1999;39:27–36.

    CAS  PubMed  Google Scholar 

  66. Pfister D, Pfister R. Acid injuries of the eye. In: Krachmer J, Mannis M, Holland E, editors. Cornea and External Disease: Diagnosis and Management. St. Louis: Mosby-Year Book, 1997;1437–1442.

    Google Scholar 

  67. Friedenwald J, Hughes W, Herman H. Acid injuries of the eye. Arch Ophthalmol 1946;35:98–108.

    Google Scholar 

  68. Holekamp T, Becker B. Ocular injuries from automobile batteries. Trans Am Acad Ophthalmol Otolaryngol 1977;83: 805–807.

    CAS  Google Scholar 

  69. Grayson M, Peroni D. Severe silver nitrate injury to the eye. Am J Ophthalmol 1970;70:227–229.

    CAS  PubMed  Google Scholar 

  70. Guidry M, Allen J, Kelly J. Some biochemical characteristics of acid injury of the cornea. Am J Ophthalmol 1955;40: 111–119.

    CAS  PubMed  Google Scholar 

  71. Friedenwald J, Hughes W, Herrmann H. Acid-base tolerance of the cornea. Arch Ophthalmol 1944;31:279–283.

    CAS  Google Scholar 

  72. Schultz G, Henkind P, Gross E. Acid injuries of the eye. Am J Ophthalmol 1968;66:654–657.

    CAS  PubMed  Google Scholar 

  73. Chinag T, Moorman L, Thomas R. Ocular hypertensive response following acid and alkali burns in rabbits. Invest Ophthalmol 1971;10:270–273.

    Google Scholar 

  74. Paterson C, Eakins K, Paterson R. The ocular hypertensive response following experimental acid burns in the rabbit eye. Invest Ophthalmol Vis Sci 1979;18:67–74.

    CAS  PubMed  Google Scholar 

  75. Friedenwald J. Discussion. Am J Ophthalmol 1955;40:119–120.

    Google Scholar 

  76. Vajpayee R, Gupta N, Angra S. Contact thermal burns of the cornea. Can J Ophthalmol 1991;26:215–218.

    CAS  PubMed  Google Scholar 

  77. Linhart R. Burns of the eyes and eyelids. Ann Ophthalmol 1978;10:999–1001.

    CAS  PubMed  Google Scholar 

  78. Guy R, Baldwin J, Kwedar S. Three years’ experience in a regional burn center with burns of the eyes and eyelids. Ophthal Surg 1982;13:383–386.

    CAS  Google Scholar 

  79. Mannis M, Miller R, Krachmer J. Contact thermal burns of the cornea from electric curling irons. Am J Ophthalmol 1984;98:336–339.

    CAS  PubMed  Google Scholar 

  80. Shahan W, Lamb H. Histologic effect of heat on the eye. Am J Ophthalmol 1916;33:225–227.

    Google Scholar 

  81. Goldblatt W, Finger P, Perry H. Hyperthermic treatment of rabbit corneas. Invest Ophthalmol Vis Sci 1989;30: 1778–1783.

    CAS  PubMed  Google Scholar 

  82. Hamill B. Corneal Injury. In: Krachmer J, Mannis M, Holland E, editors. Cornea and External Disease: Diagnosis and Management. St. Louis: Mosby-Year Book, 1997;1403–1422.

    Google Scholar 

Download references

Authors
  1. Terry Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Alyse Khosla-Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Kim, T., Khosla-Gupta, B.A. (2002). Chemical and Thermal Injuries to the Ocular Surface. In: Ocular Surface Disease Medical and Surgical Management. Springer, New York, NY. https://doi.org/10.1007/0-387-21570-0_8

Download citation

  • DOI: https://doi.org/10.1007/0-387-21570-0_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95161-4

  • Online ISBN: 978-0-387-21570-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation