Skip to main content
SpringerLink
Log in
Book cover

Chlamydia pneumoniae Infection and Disease pp 135–151Cite as

The Biology of Chlamydia pneumoniae in Cardiovascular Disease Pathogenesis

  • Chapter

  • 205 Accesses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Saikku, P., Leinonen, M., Matilla, K., el al., 1988, Serologic evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction, Lancet 2:983–986.

    CAS  PubMed  Google Scholar 

  2. Frothingham, C., 1911, The relationship between acute infectious diseases and arterial lesions, Arch. Intern. Med. 8:153–162.

    Google Scholar 

  3. Kalayoglu, M. V., Libby, P., and Byrne, G. I., 2002, Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease, JAMA 288:2724–2731.

    Article  CAS  PubMed  Google Scholar 

  4. Kol, A., Sukhova, G. K., Lichtman, A. H., and Libby, P., 1998, Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression, Circulation 98:300–307.

    CAS  PubMed  Google Scholar 

  5. Kalayoglu, M. V., Hoerneman, B., LaVerda, D., Morrison, S. G., Morrison, R. P., and Byrne, G. I., 1999, Cellular oxidation of low-density lipoprotein by Chlamydia pneumoniae, J. Infect. Dis. 180:780–790.

    Article  CAS  PubMed  Google Scholar 

  6. Kalayoglu, M. V., and Byrne, G. I., 1998, Induction of macrophage foam cell formation by Chlamydia pneumoniae, J. Infect. Dis. 177:725–729.

    CAS  PubMed  Google Scholar 

  7. Byrne, G. I., and Kalayoglu, M. V., 1999, Chlamydia pneumoniae and atherosclerosis: Links to the disease process, Am. Heart J. 138:S488–S490.

    Article  CAS  PubMed  Google Scholar 

  8. Kalman, S., Mitchell, W., Marathe, R., Lammel, C., Fan, J., Hyman, R. W., Olinger, L., Grimwood, J., Davis, R. W., and Stephens, R. S., 1999, Comparative genomes of Chlamydia pneumoniae and C. trachomatis, Nat. Genet. 21:385–389.

    CAS  PubMed  Google Scholar 

  9. Read, T. D., Brunham, R. C., Shen, C., Gill, S. R., Heidelberg, J. F., White, O., Hickey, E. K., Peterson, J., Utterback, T., Berry, K, Bass, S., Linher, K, Weidman, J., Khouri, H., Craven, B., Bowman, C., Dodson, R., Gwinn, M., Nelson, W., DeBoy, R., Kolonay, J., McClarty, G., Salzberg, S. L., Eisen, J., and Fraser, C. M., 2000, Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39, Nucleic Acids Res. 28:1397–1406.

    CAS  PubMed  Google Scholar 

  10. Shirai, M., Hirakawa, H., Kimoto, M., Tabuchi, M., Kishi, F., Ouchi, K., Shiba, T., Ishii, K., Hattori, M., Kuhara, S., and Nakazawa, T., 2000, Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA, Nucleic Acids Res. 28:2311–2314.

    Article  CAS  PubMed  Google Scholar 

  11. Gieffers, J., Belland, R.J., Whitmire, W., Ouellette, S., Crane, D., Maass, M., Byrne, G. I., and Caldwell, H. D., 2002, Isolation of Chlamydia pneumoniae clonal variants by a focus-forming assay, Infect. Immun. 70:5827–5834.

    Article  CAS  PubMed  Google Scholar 

  12. Beatty, W. L., Morrison, R. P., and Byrne, G. I., 1994, Persistent Chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis, Microbiol. Rev. 58:686–699.

    CAS  PubMed  Google Scholar 

  13. Carabeo, R. A., and Hackstadt, T., 2001, Isolation and characterization of a mutant Chinese hamster ovary cell line that is resistant to Chlamydia trachomatis infection at a novel step in the attachment process, Infect. Immun. 69:5899–5904.

    Article  CAS  PubMed  Google Scholar 

  14. Van Ooij, C., Apodaca, G., and Engel, J., 1997, Characterization of Chlamydia trachomatis vacuole and its interaction with the host endocytic pathway in HeLa cells, Infect. Immun. 65:758–766.

    PubMed  Google Scholar 

  15. Wolf, K., and Hackstadt, T., 2001, Sphingomyelin trafficking in Chlamydia pneumoniae- infected cells, Cell, Micmbiol. 3:145–152.

    CAS  Google Scholar 

  16. Byrne, G. I., Ouellette, S. P., Wang, Z., Rao, J. P., Lu, L., Beatty, W. L., and Hudson, A. P., 2001, Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of HEp-2 cells, Infect. Immun. 69:5423–5429.

    CAS  PubMed  Google Scholar 

  17. Ramsey, K. H., Miranpuri, G. S., Sigar, I. M., Ouellette, S., and Byrne, G. I., 2001, Chlamydia trachomatis persistence in the female mouse genital tract: Inducible nitric oxide synthase and infection outcome, Infect. Immun. 69:5131–5137.

    CAS  PubMed  Google Scholar 

  18. Miller, S. A., Selzman, C. H., Shames, B. D., Barton, H. A., Johnson, S. M., and Harken, A. H., 2000, Chlamydia pneumoniae activates nuclear factor kB and activator protein 1 in human vascular smooth muscle and induces cellular proliferation, J. Surg. Res. 90:76–81.

    Article  CAS  PubMed  Google Scholar 

  19. Dechend, R., Maass, M., Gieffers, J., Dietz, R., Scheidereit, C., Leutz, A., and Gulba, D. C., 1999, Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-kB and induces tissue factor and PAI-1 expression, Circulation 100:1369–1373.

    CAS  PubMed  Google Scholar 

  20. Fryer, R. H., Schwobe, E. P., Woods, M. L., and Rodgers, G. M., 1997, Chlamydia species infect human vascular endothelial cells and induce procoagulant activity, J. Invest. Med. 45:168–174.

    CAS  Google Scholar 

  21. Coombes, B. K., and Mahony, J. B., 1999, Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s), Infect. Immun. 67:2909–2915.

    CAS  PubMed  Google Scholar 

  22. Molestina, R. E., Miller, R. D., Ramirez, J. A., and Summersgill, J. T., 1999, Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes, Infect. Immun. 67:1323–1330.

    CAS  PubMed  Google Scholar 

  23. Molestina, R. E., Dean, D., Miller, R. D., Ramirez, J. A., and Summersgill, J. T., 1998, Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells, Infect. Immun. 66:1370–1376.

    CAS  PubMed  Google Scholar 

  24. Coombes, B. K, and Mahony, J. B., 2001, cDNA array analysis of altered gene expression in human endothelial cells in response to Chlamydia pneumoniae infection, Infect. Immun. 69:1420–1427.

    Article  CAS  PubMed  Google Scholar 

  25. Kothe, H., Dalhoff, K., Rupp, J., Muller, A., Kreuzer, J., Maass, M., and Katus, H. A., 2000, Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae, Circulation 101:1760–1763.

    CAS  PubMed  Google Scholar 

  26. Krull, M., Klucken, A. C., Wuppermann, F. N., Fuhrmann, O., Magerl, C., Seybold, J., Hippenstiel, S., Hegemann, J. H., Jantos, C. A., and Suttorp, N., 1999, Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae, J. Immunol. 162:4834–4841.

    CAS  PubMed  Google Scholar 

  27. Kalayoglu, M. V., Indrawati, Morrison, R. P., Morrison, S. G., Yuan, Y, and Byrne, G. I., 2000, Chlamydial virulence determinants in atherogenesis: The role of chlamydial lipopolysaccharide and heat shock protein 60 in macrophage-lipoprotein interactions, J. Infect. Dis. 181(Suppl. 3):S483–S489.

    CAS  PubMed  Google Scholar 

  28. LaVerda, D., Albanese, L. N., Ruther, P. E., Morrison, S. G., Morrison, R. P., Ault, K. A., and Byrne, G. I., 2000, Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease, Infect. Immun. 68:303–309.

    CAS  PubMed  Google Scholar 

  29. Kalayoglu, M. V., and Byrne, G. I., 1998, A Chlamydia pneumoniae component that induces macrophage foam cell formation is chlamydial lipopolysaccharide, Infect. Immun. 66:5067–5072.

    CAS  PubMed  Google Scholar 

  30. Beatty, W. L., Byrne, G. I., and Morrison, R. P., 1993, Morphological and antigenic characterization of interferon-gamma mediated persistent Chlamydia trachomatis infection in vitro, Proc. Natl. Acad. Sci. U.S.A. 90:3998–4002.

    CAS  PubMed  Google Scholar 

  31. Byrne, G. I., Lehmann, L. K., and Landry, G. J., 1986, Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells, Infect. Immun. 53:347–351.

    CAS  PubMed  Google Scholar 

  32. Gaydos, C. A., Summersgill, J. T., Sahney, N. N., Ramirez, J. A., and Quinn, T. C., 1996, Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells, Infect. Immun. 64:1614–1620.

    CAS  PubMed  Google Scholar 

  33. Haranaga, S., Yamaguchi, H., Friedman, H., Izumi, S.-I., and Yamamoto, Y., 2001, Chlamydia pneumoniae infects and multiplies in lymphocytes in vitro, Infect. Immun. 69:7753–7759.

    Article  CAS  PubMed  Google Scholar 

  34. Moazed, T. C., Kuo, C., Grayston, J. T., and Campbell, L. A., 1997, Murine models of Chlamydia pneumoniae infection and atherosclerosis, J. Infect. Dis. 175:883–890.

    CAS  PubMed  Google Scholar 

  35. Yamaguchi, H., Haranaga, S., Widen, R., Friedman, H., and Yamamoto, Y, 2002, Chlamydia pneumoniae infection induces differentiation of monocytes into macrophages, Infect. Immun. 70:2392–2398.

    CAS  PubMed  Google Scholar 

  36. Kalayoglu, M. V., Perkins, B. N., and Byrne, G. I., 2001, Chlamydia pneumoniae-infected monocytes exhibit increased adherence to human aortic endothelial cells, Microb. Infect. 3:963–969.

    CAS  Google Scholar 

  37. Grimwood, J., Olinger, L., and Stephens, R. S., 2001, Expression of Chlamydia pneumoniae polymorphic membrane protein family genes, Infect. Immun. 69:2383–2389.

    Article  CAS  PubMed  Google Scholar 

  38. Vandahl, B. B., Birkelund, S., Demol, H., Hoorelbeke, B., Christiansen, G., Vandekerckhove, J., and Gevaert, K., 2001, Proteome analysis of the Chlamydia pneumoniae elementary body, Electrophoresis 22:1204–1223.

    CAS  PubMed  Google Scholar 

  39. Montigiani, S., Falugi, F., Scarselli, M., Finco, O., Petracca, R., Galli, G., Mariani, M., Manetti, R., Agnusdei, M., Cevenini, R., Donati, M., Nogarotto, R., Norais, N., Garaguso, I., Nuti, S., Saletti, G., Rosa, D., Ratti, G., and Grandi, G., 2002, Genomic approach for analysis of surface proteins in Chlamydia pneumoniae, Infect, Immun. 70:368–379.

    Article  CAS  Google Scholar 

  40. Rocha, E. P. C., Pradillon, O., Bui, H., Sayada, C., and Denamur, E., 2002, A new family of highly variable proteins in the Chlamydophila pneumoniae genome, Nucleic Acids Res. 30:4351–4360.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Tennessee Health Science Center, Memphis, Tennessee

    Scot P. Ouellette, Robert J. Belland & Gerald I. Byrne

  2. Medical University of Luebeck, Luebeck, Germany

    Jens Gieffers

Authors
  1. Scot P. Ouellette
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert J. Belland
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jens Gieffers
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gerald I. Byrne
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of South Florida College of Medicine, Tampa, Florida

    Herman Friedman

  2. Osaka University, Osaka, Japan

    Yoshimasa Yamamoto

  3. University of Pisa, Pisa, Italy

    Mauro Bendinelli

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science + Business Media, Inc.

About this chapter

Cite this chapter

Ouellette, S.P., Belland, R.J., Gieffers, J., Byrne, G.I. (2005). The Biology of Chlamydia pneumoniae in Cardiovascular Disease Pathogenesis. In: Friedman, H., Yamamoto, Y., Bendinelli, M. (eds) Chlamydia pneumoniae Infection and Disease. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-48741-1_10

Download citation

  • DOI: https://doi.org/10.1007/0-306-48741-1_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-48487-2

  • Online ISBN: 978-0-306-48741-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation