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Pathologic Examination of the Sentinel Lymph Node

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Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 111))

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Conclusion

The technique of sentinel lymph node biopsy has permitted accurate identification by surgeons and nuclear medicine physicians of the first node to receive direct drainage from an area of tumor. This selective dissection of the first draining node has had the added benefit of dramatically reducing the number of nodes the pathologist must examine in the search for metastatic tumor. This in turn has made feasible the routine examination of multiple levels of the submitted lymph node tissue and the routine use of immunohistochemical stains, both of which had been proven, even in the pre-sentinel lymph node era, to improve detection of occult metastases, which impart a poor prognosis. While the optimal method for pathologic examination of the sentinel lymph node remains “a work in progress”, examination of at least three levels of the block, and the routine use of immunohistochemical stains for antigens such as S-100 (for melanoma) and keratin proteins (for carcinoma) seems to constitute the current “standard of care”. The value of highly sensitive methods, such as PCR, in the search for occult metastases remains a subject of active investigation.

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  1. Patrick A. Treseler MD, PhD
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  1. University of California, San Francisco, USA

    Stanley P. L. Leong

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Treseler, P.A. (2002). Pathologic Examination of the Sentinel Lymph Node. In: Leong, S.P.L. (eds) Atlas of Selective Sentinel Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer. Cancer Treatment and Research, vol 111. Springer, Boston, MA. https://doi.org/10.1007/0-306-47822-6_5

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  • DOI: https://doi.org/10.1007/0-306-47822-6_5

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