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Biology of Human Immunodeficiency Virus Type 2 (HIV-2)

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Book cover AIDS in Africa

Conclusion

Since the discovery of HIV-2 in 1985, considerable progress has been made in understanding its virology and epidemiology. The data suggest differences between HIV-2 and HIV-1 in geographic distribution, distinct epidemic trends, perinatal transmission rates, and incubation periods to the development of AIDS. The virologic determination and mechanisms for these apparent biologic differences are still unknown. However, understanding how HIV-2 differs from HIV-1 is essential to interpretations of comparative virologic studies. We hope such comparative studies will yield important information on the pathogenic mechanisms employed by HIV viruses and will lead the way to the development of effective interventions for the prevention of AIDS. This is best exemplified in studies indicating that this close relative of HIV-1 infection, via its attenuated phenotype, may confer significant protection from subsequent infection by HIV-1. This further suggests that understanding HIV-2 immunity and cross-immunity may be useful for HIV vaccine design and development.

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Authors and Affiliations

  1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard AIDS Institute, Boston, Massachusetts, 02115, USA

    Phyllis J. Kanki & Jean-Louis Sankalé

  2. Department of Bacteriology and Virology, Cheikh Anta Diop University, Dakar, Senegal

    Souleymane Mboup

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  1. Phyllis J. Kanki
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  2. Jean-Louis Sankalé
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  3. Souleymane Mboup
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Editors and Affiliations

  1. Harvard AIDS Institute Mary Woodard Lasker Professor of Health Sciences Harvard University, Boston, Massachusetts, USA

    Max Essex DVM, PhD (Chairman) & Richard G. Marlink MD (Senior Research and Executive Director) (Chairman) &  (Senior Research and Executive Director)

  2. Laboratory of Bacteriology and Virology CHU Le Dantec, Université Cheikh Anta Diop, Dakar, Senegal

    Souleymane Mboup PharmD, PhD (Professor of Microbiology) (Professor of Microbiology)

  3. Department of Immunology and Infectious Diseases and the Harvard AIDS Institute, Harvard School of Public Health, Boston, Massachusetts, USA

    Phyllis J. Kanki DVM, DSc (Professor of Immunology and Infectious Diseases) & Molly Holme (Professor of Immunology and Infectious Diseases) & 

  4. Department of Nursing Education University of Botswana, Gaborone, Botswana

    Sheila D. Tlou PhD (Associate Professor) (Associate Professor)

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© 2002 Kluwer Academic Publishers

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Kanki, P.J., Sankalé, JL., Mboup, S. (2002). Biology of Human Immunodeficiency Virus Type 2 (HIV-2). In: Essex, M., Mboup, S., Kanki, P.J., Marlink, R.G., Tlou, S.D., Holme, M. (eds) AIDS in Africa. Springer, Boston, MA. https://doi.org/10.1007/0-306-47817-X_5

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  • DOI: https://doi.org/10.1007/0-306-47817-X_5

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