8. Conclusion
The aberrations and defects in the parts of innate immunity, which are of clinical significance, described above, probably represent the tip of the iceberg. The relatively high incidence of gene mutations and decreased production of MBL in the general population, may be paralleled by a similar situation for other lectin-binding molecules, remaining to be determined. We are faced in the clinics by numerous cases of recurrent infections, the cause of which remains unexplained, when submitted to the current routine immunological investigations. More intensive research efforts in defects of innate immunity may contribute to the deciphering of some of those cases.
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Handzel, Z.T. (2002). Clinical Significance of Functional Aberrations in Macrophage and NK Cells, in Type-1 Cytokines and in Lectin-Binding Molecules. In: Keisari, Y., Ofek, I. (eds) The Biology and Pathology of Innate Immunity Mechanisms. Advances in Experimental Medicine and Biology, vol 479. Springer, Boston, MA. https://doi.org/10.1007/0-306-46831-X_20
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