Date: 02 Dec 2007

Models of protein adsorption on solid surfaces

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Abstract

A dynamic model of protein adsorption on solid surfaces is presented. It is based on the assumption that a protein molecule may change conformation after adsorption. The computed adsorption isotherms are similar in form to experimentally observed isotherms. A model for the experimentally observed reversible potential changes at a metal electrode upon protein adsorption/desorption is also discussed. It is thus suggested that a second loosely bound protein layer may be present on several metal surfaces. Some notes are also made about the significance of the time scale and detailed method of performing an adsorption experiment.