Chapter

Reviews of Physiology, Biochemistry and Pharmacology, Volume 135

Volume 135 of the series Reviews of Physiology, Biochemistry and Pharmacology pp 1-39

Date:

Mechanisms of regulation and functions of guanylyl cyclases

  • D. C. FosterAffiliated withHoward Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center
  • , B. J. WedelAffiliated withHoward Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center
  • , S. W. RobinsonAffiliated withHoward Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center
  • , D. L. GarbersAffiliated withHoward Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Although enormous progress in understanding guanylyl cyclase structure and regulation has been recently made, many questions remain. There are now numerous guanylyl cyclase sequences, and signature sequences for discrete domains within these molecules can be identified. The majority of the guanylyl cyclases identified, however are orphan receptors. A primary goal, therefore, is the identification of ligands for the numerous orphan receptor guanylyl cyclases. Identification of these molecules may provide insight into systems such as vision and olfaction among others. In addition, it will be of interest to identify guanylyl cyclase regulatory proteins. These molecules may provide insight into guanylyl cyclase regulation and provide targets for other signaling pathways to modulate guanylyl cyclase activity. Finally, the information gained from structural studies of adenylyl cyclase has shed new light on the guanylyl cyclase catalytic domain, and raised the possibility of a previously unidentified regulatory pocket within the catalytic domain. Understanding the role of this potential regulatory region may provide new insight into not only guanylyl cyclase regulation, but numerous physiological processes.