Chapter

Advanced Trauma and Surgery

pp 357-385

Date:

Stem Cell Based Biotherapy for Radiation Related Injury

  • Tingyu DaiAffiliated withState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University
  • , Liao WuAffiliated withState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University
  • , Zelin ChenAffiliated withState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University
  • , Chunmeng ShiAffiliated withState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University Email author 

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Radiation injury occurs after nuclear explosives, radiological or nuclear terrorism, nuclear accidents, and radiation therapy in combination with surgery, and it is more complicated and difficult to heal than single radiation or wound injuries. The stem cell-based therapy holds promise for radiation related injuries treatment. In this review, we summarized some representative biological properties of MSCs pre- and post-irradiation, discussed the feasibility of MSCs to apply to the treatment of radiation injuries on animal models and clinical patients, and elucidated the mechanisms of MSCs-based therapy to radiation injuries.

Keywords

Radiation Stem cells Skin Radiation related injuries Biotherapy