Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 77-103

Date:

Telocytes: New Players in Gallstone Disease

  • Artur PasternakAffiliated withFirst Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University Medical CollegeDepartment of Anatomy, Jagiellonian University Medical College Email author 
  • , Krzysztof GilAffiliated withDepartment of Pathophysiology, Jagiellonian University Medical College
  • , Andrzej MatyjaAffiliated withFirst Department of General, Oncological and Gastrointestinal Surgery, Jagiellonian University Medical College

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Abstract

Cholesterol gallstone disease is highly prevalent in Western countries, particularly in women and some specific ethnic groups. The mechanisms behind the formation of gallstones are not clearly understood, but gallbladder dysmotility seems to be a key factor that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile.

Given that newly described interstitial cells, telocytes, are present in the gallbladder and they are located in close vicinity of smooth muscle cell and neural fibers possibly interfering with gallbladder motility or contractility, authors are trying to summarize the current knowledge on the role of telocytes with respect to disturbed gallbladder function in gallstone disease.

Keywords

Telocytes Gallstone disease Cholesterol saturation index Bile lithogenicity