Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 335-357

Date:

Immunohistochemistry of Telocytes in the Uterus and Fallopian Tubes

  • Sanda Maria CretoiuAffiliated withVictor Babeş National Institute of PathologyDivision of Cell Biology and Histology, Carol Davila University of Medicine and Pharmacy Email author 

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Abstract

The seminal work of Popescu and colleagues first demonstrated the existence of a new cell type – the telocytes. We were among the first who reported the presence of such cells in the female genital tract and performed TEM examinations, as well as immunohistochemical staining in the attempt to find a specific marker. Telocytes from rat and from the human uterus and from human fallopian tube were extensively investigated initially by comparison with interstitial cells of Cajal. Progress in telocyte research led to the identification of different subtypes suggestive for a heterogeneous telocyte population which can even coexist in the same location. As a consequence, the functions of TCs are still elusive and can be considered a versatile phenomenon that depends on a variety of conditions, including signal reception and transmission of information via extracellular vesicles or by direct intercellular contact.

Keywords

Telocytes Telopodes Immunocytochemical phenotype Uterus Fallopian tube