Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 23-39

Date:

Decoding Telocytes

  • Junjie XiaoAffiliated withRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University Email author 
  • , Yihua BeiAffiliated withRegeneration and Ageing Lab, Experimental Center of Life Sciences, School of Life Science, Shanghai University

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Abstract

Telocytes (TCs) are a novel type of interstitial cells, with extremely long and thin cellular prolongations termed telopodes (Tps). TCs were first identified by Popescu et al. and described their finding as “cells with telopodes.” The presence of TCs has been reported in the majority of tissues and organs (for details please visit www.​telocytes.​com). TCs have been ignored or overlooked for a long time due to our inability to observe these cells via a light microscopy. TCs represent a distinct cell population, different from other types of interstitial cells, based on their distinct (ultra)structure, immunophenotype, microRNA profile, gene feature, proteome signature, and secretome features. As TCs have been suggested as new cellular targets for forthcoming therapies, developing specific methods to modulate TC numbers represents an important objective.

Keywords

Telocytes Telopodes Interstitial cells MicroRNA Gene Proteome Secretome