Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 263-285

Date:

Telocytes in Inflammatory Gynaecologic Diseases and Infertility

  • Xiao-Jun YangAffiliated withDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University Email author 

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Women suffered with inflammatory gynecologic diseases, such as endometriosis (EMs) and acute salpingitis (AS) often complained of sub- or infertility, even in those women without obvious macroscopic anatomical pelvic abnormalities also have unexplained infertility. Generally, besides the well-known impairment of classically described oviduct cells caused by inflammatory diseases, such as the ciliated cells, fibroblasts and myofibroblasts, the involvement of the newly identified telocytes (TCs) in disease-affected oviduct tissues and potential pathophysiological roles in fertility problems remain unknown. In this chapter, TCs was investigated in rat model of EMs- and AS-affected oviduct tissues. Results showed inflammation and ischaemia-induced extensive ultrastructural damages of TCs both in cellular body and prolongations, with obvious TCs loss and interstitial fibrotic remodelling. Such in vivo pathological alterations might contribute to structural and functional abnormalities of oviduct tissue and potentially engaged in sub- or infertility. And especially, TCs connected to various activated immunocytes in both normal and diseased tissues, thus might participate in local immunoregulation (either repression or activation) and serve a possible explanation for immune-mediated pregnancy failure. Then, in vitro cell co-culture study showed that uterine TC conditioned media (TCM) can activate mouse peritoneal macrophages and subsequently trigger its cytokine secretion, thus providepreliminary evidence that, TCs are not simply innocent bystanders, but are instead potential functional players in local immunoregulatory and immunosurveillance.

Keywords

Uterine telocytes Interstitial cells Stromal cells Endometriosis Pelvic inflammatory disease Acute salpingitis (AS) Inflammation Inflammatory factors Infertility Fertility disorder Tubal ectopic pregnancy Tubal factor infertility Rat model Oviduct Fibrosis Immunoregulation Immune response Macrophage activation Cytokines Enzyme