Chapter

Telocytes

Volume 913 of the series Advances in Experimental Medicine and Biology pp 193-206

Date:

Paracrine Signaling in the Prostatic Stroma: A Novel Role for the Telocytes Revealed in Rodents’ Ventral Prostate

  • Bruno D. A. SanchesAffiliated withDepartment of Structural and Functional Biology, State University of Campinas – UNICAMPLaboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista – UNESP
  • , Lara S. CorradiAffiliated withCampus de Araguaína – Escola de Medicina Veterinária e Zootecnia, Fund. Univ. Federal do TocantinsLaboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista – UNESP
  • , Patricia S. L. VilamaiorAffiliated withCampus de Araguaína – Escola de Medicina Veterinária e Zootecnia, Fund. Univ. Federal do TocantinsLaboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista – UNESP
  • , Sebastião R. TabogaAffiliated withDepartment of Structural and Functional Biology, State University of Campinas – UNICAMPLaboratory of Microscopy and Microanalysis, Department of Biology, Univ. Estadual Paulista – UNESP Email author 

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Abstract

The telocytes have recently been described in the prostate gland. In mature gland, they exist in close association with the acini and their telopodes form networks whose functions remain unclear. In this chapter, our group gives a brief introduction to telocytes and explores the history that led to such a concept and then discusses hypotheses and presents new evidences about the roles exerted by telocytes in the prostate. First is given emphasis on the role that these cells possibly play in paracrine signaling employed in the differentiation of smooth muscle periacinar are then discussed other roles potentially performed by telocytes in the prostate, such as the organizational, where these cells would act in order to delimit stromal microenvironments, thereby assisting the differentiation of the prostatic anatomical components. In addition, the pacemaker function of smooth muscle cells contraction, as evidenced by the presence of caveolae and gap-type junction and, finally, the role of telocytes in prostate remodeling and the possible action as adult progenitor cells. Generally speaking, the chapter reaffirms the existence of telocytes as distinct cells of other stromal cells and the importance of this new cell type for normal metabolism and prostate development.

Keywords

Ventral prostate Paracrine signaling Prostatic stroma Epithelium-stroma interaction Prostate development