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Integrin αEβ7: Molecular Features and Functional Significance in the Immune System

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Book cover I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

Alpha E beta 7 (αEβ7) is an α-I domain-containing integrin that is highly expressed by a variety of leukocyte populations at mucosal sites including intraepithelial T cells, dendritic cells, mast cells, and T regulatory cells (Treg). Expression depends largely or solely on transforming growth factor beta (TGF-β) isoforms. The best characterized ligand for αEβ7 is E-cadherin on epithelial cells, though there is evidence of a second ligand in the human system. An exposed acidic residue on the distal aspect of E-cadherin domain 1 interacts with the MIDAS site in the αE α-I domain. By binding to E-cadherin, αEβ7 contributes to mucosal specific retention of leukocytes within epithelia. Studies on αE knockout mice have identified an additional important function for this integrin in allograft rejection and have also indicated that it may have a role in immunoregulation. Recent studies point to a multifaceted role for αEβ7 in regulating both innate and acquired immune responses to foreign antigen.

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Authors and Affiliations

  1. Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA

    Gregg A. Hadley

  2. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA, 02115, USA

    Jonathan M. G. Higgins

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  1. Gregg A. Hadley
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  2. Jonathan M. G. Higgins
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Correspondence to Gregg A. Hadley .

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  1. University of Bergen, Bergen, Norway

    Donald Gullberg

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Hadley, G.A., Higgins, J.M.G. (2014). Integrin αEβ7: Molecular Features and Functional Significance in the Immune System. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_7

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