Chapter

Lactic Acid Bacteria: Genetics, Metabolism and Applications

pp 29-58

Discovering lactic acid bacteria by genomics

  • Todd KlaenhammerAffiliated withDepartment of Food Science, Southeast Dairy Foods Research Center, North Carolina State University
  • , Eric AltermannAffiliated withDepartment of Food Science, Southeast Dairy Foods Research Center, North Carolina State University
  • , Fabrizio ArigoniAffiliated withNestlé Research Center
  • , Alexander BolotinAffiliated withGénétique Microbienne, CRJ INRA
  • , Fred BreidtAffiliated withUSDA Agricultural Research Service, Department of Food Science, North Carolina State University
  • , Jeffrey BroadbentAffiliated withDepartment of Nutrition and Food Sciences, Utah State University
  • , Raul CanoAffiliated withEnvironmental Biotechnology Institute, California Polytechnic State University
  • , Stephane ChaillouAffiliated withFlore Lactique et Environnement Carné, INRA-CRJ, Domaine de Vilvert
  • , Josef DeutscherAffiliated withLaboratoire de Génétique des Microorganismes, INRA-CNRS URA1925
    • , Mike GassonAffiliated withInstitute of Food Research
    • , Maarten van de GuchteAffiliated withGénétique Microbienne, CRJ INRA
    • , Jean GuzzoAffiliated withLaboratoire de Microbiologie, UMR INRA-Université de Bourgogne
    • , Axel HartkeAffiliated withLaboratoire de Microbiologie de l’Environnement, EA 956 USC INRA, IRBA Université de Caen
    • , Trevor HawkinsAffiliated withJoint Genome Institute Production Genomic Facility
    • , Pascal HolsAffiliated withUnité de Génétique, Batiment Camoy, Place Croix du Sud, UCL
    • , Robert HutkinsAffiliated withDepartment of Food Science and Technology, University of Nebraska
    • , Michiel KleerebezemAffiliated withWageningen Center for Food Sciences
    • , Jan KokAffiliated withDepartment of Molecular Genetics, University of Groningen
    • , Oscar KuipersAffiliated withDepartment of Molecular Genetics, University of Groningen
    • , Mark LubbersAffiliated withFonterra Research Centre [Formerly the New Zealand Dairy Research Institute]
    • , Emmanuelle MaguinAffiliated withGénétique Microbienne, CRJ INRA
    • , Larry McKayAffiliated withDepartment of Food Science and Nutrition, University of Minnesota
    • , David MillsAffiliated withDepartment of Viticulture and Enology, University of California
    • , Arjen NautaAffiliated withCorporate Research FCDF
    • , Ross OverbeekAffiliated withInteregated Genomics Inc
    • , Herman PelAffiliated withDSM Food Specialties
    • , David PridmoreAffiliated withNestlé Research Center
    • , Milton SaierAffiliated withUniversity California, San Diego
    • , Douwe van SinderenAffiliated withDepartment of Microbiology, University College Cork
    • , Alexei SorokinAffiliated withGénétique Microbienne, CRJ INRA
    • , James SteeleAffiliated withDepartment of Food Science,University of Wisconsin-Madison, Madison, University of Wisconsin-Madison
    • , Daniel O’SullivanAffiliated withDepartment of Food Science and Nutrition, University of Minnesota
    • , Willem de VosAffiliated withWageningen Center for Food Sciences
    • , Bart WeimerAffiliated withDepartment of Nutrition and Food Sciences, Utah State University
    • , Monique ZagorecAffiliated withFlore Lactique et Environnement Carné, INRA-CRJ, Domaine de Vilvert
    • , Roland SiezenAffiliated withCenter for Molecular and Biomolecular Informatics, University of NijmegenWageningen Center for Food Sciences

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Abstract

This review summarizes a collection of lactic acid bacteria that are now undergoing genomic sequencing and analysis. Summaries are presented on twenty different species, with each overview discussing the organisms fundamental and practical significance, environmental habitat, and its role in fermentation, bioprocessing, or probiotics. For those projects where genome sequence data were available by March 2002, summaries include a listing of key statistics and interesting genomic features. These efforts will revolutionize our molecular view of Gram-positive bacteria, as up to 15 genomes from the low GC content lactic acid bacteria are expected to be available in the public domain by the end of 2003. Our collective view of the lactic acid bacteria will be fundamentally changed as we rediscover the relationships and capabilities of these organisms through genomics.

Key words

lactic acid bacteria genomics Gram-positive bacteria food health Lactococcus Lactobacillus Streptococcus Pediococcus Leuconostoc Oenococcus Propionibacterium Bifidobacterium Brevibacterium