Prostaglandins: Chemical and Biochemical Aspects

pp 25-85

Methods for Analysis of Prostaglandins

  • J. A. Salmon
  • , Sultan M. M. Karim

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After the initial discovery of the acidic, lipid-soluble, smooth muscle stimulating compounds (prostaglandins) in seminal fluid (Goldblatt, 1933, 1935; Von Euler, 1934, 1935, 1936) there was a long period of inactivity in the study of these compounds. This was attributable to lack of suitable techniques for qualitative and quantitative determination of the active components. The only means of detection were the sensitive but relatively unspecific bioassays which did not permit chemical identification.