Viral Contaminants Found in Mouse Cell Lines Used in the Production of Biological Products
- Stephen J. FroudAffiliated withLonza Biologics (previously Celltech Biologics)
- , John BirchAffiliated withLonza Biologics (previously Celltech Biologics)
- , Carol McLeanAffiliated withQ-One Biotech Ltd.
- , Alasdair J. ShepherdAffiliated withQ-One Biotech Ltd.
- , Kenneth T. SmithAffiliated withQ-One Biotech Ltd.
Murine hybridoma and plasmacytoma cell lines are used in the production of biologics for human use such as therapeutic monoclonal antibodies and recombinant proteins. Most of these cell lines produce retro virus-like particles and in many cases infectious C type murine leukaemia virus (MLV) which can be either ecotropic (infectious for cell lines of murine origin or a closely related species) or xenotropic (infectious for species other than murine; X-MLV).
- Viral Contaminants Found in Mouse Cell Lines Used in the Production of Biological Products
- Book Title
- Animal Cell Technology
- Book Subtitle
- From Vaccines to Genetic Medicine
- Book Part
- Session VII
- pp 681-686
- Print ISBN
- Online ISBN
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media Dordrecht
- Additional Links
- eBook Packages
- Editor Affiliations
- 1. IBET
- 2. CAMR
- Author Affiliations
- 3. Lonza Biologics (previously Celltech Biologics), 216 Bath Road, Slough, Berkshire, SL1 4EN, UK
- 4. Q-One Biotech Ltd., Todd Campus, Maryhill Road, Glasgow, G20 OXA, UK
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