Chapter

Mechanics of Elastic Biomolecules

pp 535-540

Mechanics of vimentin intermediate filaments

  • Ning WangAffiliated withPhysiology Program, Harvard School of Public Health Email author 
  • , Dimitrijie StamenovicAffiliated withDepartment of Biomedical Engineering, Boston University

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Abstract

It is increasingly evident that the cytoskeleton of living cells plays important roles in mechanical and biological functions of the cells. Here we focus on the contribution of intermediate filaments (IFs) to the mechanical behaviors of living cells. Vimentin, a major structural component of IFs in many cell types, is shown to play an important role in vital mechanical and biological functions such as cell contractility, migration, stiffness, stiffening, and proliferation.