Interrelations between Essential Metal Ions and Human Diseases

Volume 13 of the series Metal Ions in Life Sciences pp 49-79


Magnesium in Health and Disease

  • Andrea M. P. RomaniAffiliated withDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University Email author 

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Mammalian cells tightly regulate cellular Mg2+ content through a variety of transport and buffering mechanisms under the control of various hormones and cellular second messengers. The effect of these hormones and agents results in dynamic changes in the total content of Mg2+ being transported across the cell membrane and redistributed within cellular compartments. The importance of maintaining proper cellular Mg2+ content optimal for the activity of various cellular enzymes and metabolic cycles is underscored by the evidence that several diseases are characterized by a loss of Mg2+ within specific tissues as a result of defective transport, hormonal stimulation, or metabolic impairment. This chapter will review the key mechanisms regulating cellular Mg2+ homeostasis and their impairments under the most common diseases associated with Mg2+ loss or deficiency.


alcoholism cancer cell cycle diabetes homeostasis hormones hypertension inflammation insulin metastases Mg2+ Mg2+ transport