Tumors of the Central Nervous System, Volume 11

Volume 11 of the series Tumors of the Central Nervous System pp 3-20


An Introduction to Brain Tumor Imaging

  • Amit MehndirattaAffiliated withKeble College, University of Oxford Email author 
  • , Yee Kai TeeAffiliated withWolfson College, University of Oxford
  • , Stephen J. PayneAffiliated withInstitute of Biomedical Engineering, University of Oxford
  • , Michael A. ChappellAffiliated withInstitute of Biomedical Engineering, University of Oxford
  • , Frederik L. GieselAffiliated withDepartment of Nuclear Medicine, University Hospital Heidelberg

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Brain tumors are among the leading causes of tumor-related deaths globally; hence considerable research effort is being expended to improve the patient outcome. There are now multiple imaging techniques available for the diagnosis and management of brain tumors in clinical practice, as well as different contrast agents. All these coupled with amino acid tracers newly available in positron emission tomography can offer more accurate tumor diagnosis. The evaluation of tumors using multiple imaging modalities is now one of the trends in neuroradiology, where computed tomography (CT), magnetic resonance imaging (MRI) and molecular imaging all play a vital role in the brain tumor assessment.

In this chapter, we will cover the clinical applications of computed tomography, magnetic resonance imaging with and without gadolinium contrast agents including perfusion weighted imaging, amide proton transfer imaging and magnetic resonance spectroscopy, and positron emission tomography (PET) for the evaluation of brain tumors. The advantages and limitations of each modality, as well as how they perform with respect to certain specific clinical questions.