Chapter

Metallomics and the Cell

Volume 12 of the series Metal Ions in Life Sciences pp 169-201

Date:

Manganese Homeostasis and Transport

  • Jerome RothAffiliated withDepartment of Pharmacology and Toxicology, University at Buffalo School of Medicine
  • , Silvia PonzoniAffiliated withDepartamento de Ciências Fisiológicas, CCB, Universidade Estadual de Londrina
  • , Michael AschnerAffiliated withDepartment of Pediatrics, Vanderbilt University Medical Center Email author 

Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson’s disease (PD) and sensitivity to Mn.

Keywords

divalent metal transporter 1 (DMT1) manganese mitochondria parkin transport Please cite as: Met. Ions Life Sci. 12 (2013) 169–201