Applications of Network Bioinformatics to Cancer Angiogenesis

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Abstract

Angiogenesis is the formation of new blood vessels from preexisting microvessels. Excessive and insufficient angiogenesis has been associated with many diseases including cancer, age-related macular degeneration, ischemic heart, brain, and skeletal muscle diseases. In this book chapter, we focus on the biological networks associated with angiogenesis in cancer. We review diverse studies on angiogenesis networks, including angiogenic signaling and angiogenic switch networks, global angiogenesis protein-protein interaction networks, crosstalk among angiogenic pathways, and drug networks. This chapter is for readers who are interested in cancer systems biology and bioinformatics, especially in angiogenesis.