Date: 29 Mar 2012

In-Silico Models as a Tool for the Design of Specific Treatments: Applications in Bone Regeneration

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Abstract

Numerous pathologies related to bone regeneration such as bone healing or distraction osteogenesis are focus of intense research nowadays since there are many cues not well understood yet. Intense activity is performed in both experimental and computational fields. However, in silico models may play a relevant role since computer simulations allow to consider and control factors that cannot be easily controlled or measured in experimental tests. In addition, experiments can be time-consuming, expensive and with a high difficulty to control all the parameters. This review addresses some of the main problems of in-silico models and focus on bone healing and distraction osteogenesis as mechanical based pathologies extensively investigated in the last decades.