Chapter

Calcium Signaling

Volume 740 of the series Advances in Experimental Medicine and Biology pp 1175-1191

Date:

Proarrhythmic Atrial Calcium Cycling in the Diseased Heart

  • Niels VoigtAffiliated withDivision of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg
  • , Stanley NattelAffiliated withMontreal Heart Institute, University of Montreal and Research Center
  • , Dobromir DobrevAffiliated withDivision of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg Email author 

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Abstract

During the last decades Ca2+ has been found to play a crucial role in cardiac arrhythmias associated with heart failure and a number of congenital arrhythmia syndromes. Recent studies demonstrated that altered atrial Ca2+ cycling may promote the initiation and maintenance of atrial fibrillation, the most common clinical arrhythmia that contributes significantly to population morbidity and mortality. This article describes physiological Ca2+ cycling mechanisms in atrial cardiomyocytes and relates them to fundamental cellular proarrhythmic mechanisms involving Ca2+ signaling abnormalities in the atrium during atrial fibrillation.

Keywords

Calcium Atrial arrhythmias Remodeling Ion channels Reentry Triggered activity