Aging Research in Yeast

Volume 57 of the series Subcellular Biochemistry pp 101-121


Chronological Aging in Saccharomyces cerevisiae

  • Valter D. LongoAffiliated withDepartment of Biological Sciences, Andrus Gerontology Center, University of Southern California Email author 
  • , Paola FabrizioAffiliated withLaboratory of Molecular and Cellular Biology, UMR5239 CNRS, Ecole Normale Supérieure de Lyon Email author 

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The two paradigms to study aging in Saccharomyces cerevisiae are the chronological life span (CLS) and the replicative life span (RLS). The chronological life span is a measure of the mean and maximum survival time of non-dividing yeast populations while the replicative life span is based on the mean and maximum number of daughter cells generated by an individual mother cell before cell division stops irreversibly. Here we review the principal discoveries associated with yeast chronological aging and how they are contributing to the understanding of the aging process and of the molecular mechanisms that may lead to healthy aging in mammals. We will focus on the mechanisms of life span regulation by the Tor/Sch9 and the Ras/adenylate cyclase/PKA pathways with particular emphasis on those implicating age-dependent oxidative stress and DNA damage/repair .


Chronological aging TOR (target of rapamycin) RAS Adaptive regrowth Caloric restriction