Chapter

Aging Research in Yeast

Volume 57 of the series Subcellular Biochemistry pp 13-54

Date:

Oxidative Stresses and Ageing

  • May T. Aung-HtutAffiliated withSchool of Biotechnology and Biomolecular Sciences, University of New South Wales
  • , Anita AyerAffiliated withSchool of Biotechnology and Biomolecular Sciences, University of New South Wales
  • , Michael BreitenbachAffiliated withDivision of Genetics, Department of Cell Biology, University of Salzburg
  • , Ian W. DawesAffiliated withSchool of Biotechnology and Biomolecular Sciences, University of New South Wales Email author 

Abstract

Oxidative damage to cellular constituents has frequently been associated with aging in a wide range of organisms. The power of yeast genetics and biochemistry has provided the opportunity to analyse in some detail how reactive oxygen and nitrogen species arise in cells, how cells respond to the damage that these reactive species cause, and to begin to dissect how these species may be involved in the ageing process. This chapter reviews the major sources of reactive oxygen species that occur in yeast cells, the damage they cause and how cells sense and respond to this damage.

Keywords

Oxidative stress Redox ROS (reactive oxygen species) Radical Defence